Properties of cytotoxic peptide-formed ion channels

American Journal of Physiology - Cell Physiology

Volumn 278, Issue 6 47-6, 2000, Pages

  Kourie, J I ^a   Shorthouse, A A ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Amyloids; Calcium homeostasis; Cell death; Cytotoxic peptides; Ion channels; Toxins

Indexed keywords

AMYLIN; AMYLOID; AMYLOID BETA PROTEIN; CARRIER PROTEIN; CYTOTOXIC FACTOR; DEFENSIN; DERMASEPTIN; ION CHANNEL; MAGAININ 1; MAGAININ 2; MELITTIN; PEPTIDE; PRION PROTEIN; SCORPION VENOM; VENOM;

ALPHA HELIX; CALCIUM HOMEOSTASIS; CELL DEATH; CELL MEMBRANE; CYTOTOXICITY; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANURA; APOIDEA; ARANEAE; CANIS; CYPRINUS CARPIO; FORMICIDAE; INSECTA; INVERTEBRATA; LYCOSIDAE; MAMMALIA; SCORPIONES; XENOPUS LAEVIS;

EID: 0033946014     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.278.6.c1063     Document Type: Review

References (6)

1. Andersson M, Curstedt T, Jornvall H, and Johansson J. An amphipathic helical motif common to tumourolytic polypeptide NK-lysin and pulmonary surfactant polypeptide SP-B. FEBS Lett 362: 328-332, 1995.
2. Andersson M, Girard R, and Cazenave P. Interaction of NK lysin, a peptide produced by cytolytic lymphocytes, with endotoxin. Infect Immun 67: 201-205, 1999.
3. Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Olsson B, Dagerlind A, Wigzell H, Boman HG, and Gudmundsson HG. NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells. Vet Immunol Immunopathol 54: 123-126, 1996.
4. Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, Jornvall H, Mutt V, Olsson B, Wigzell H, Dagerlind A, Boman HG, and Gudmundsson HG. 1NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity. EMBO J 14: 1615-1625, 1995.
5. Andersson M, Holmgren A, and Spyrou G. NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity. J Biol Chem 271: 10116-10120, 1996.
6. Arispe N, Pollard HB, and Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes. Proc Natl Acad Sci USA 90: 10573-10577, 1993.