Aurora-A contributes to radioresistance by increasing NF-B DNA binding

Radiation Research

Volumn 174, Issue 3, 2010, Pages 265-273

  Oh, Eun Taex ^a   Byun, Mi Sun ^a   Lee, Hyemi ^a   Park, Moon Taek ^a   Jue, Dae Myung ^b   Lee, Chang Woo ^c   Lim, Byung Uk ^a   Park, Heon Joo ^a  

^a Inha University School of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; DNA; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; AURORA KINASE; PRIMER DNA; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIOSENSITIVITY; REPORTER GENE; SIGNAL TRANSDUCTION; SURVIVAL; WILD TYPE; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENCE MICROSCOPY; GENE SILENCING; GENETICS; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; DNA; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RNA, SMALL INTERFERING; AURORA KINASES;

EID: 77956192675     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2017.1     Document Type: Article

References (38)

1. Y. Jiang, Y. Zhang, E. Lees and W. Seghezzi, AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 22, 8293-8301 (2003).
2. Q. Liu and J. V. Ruderman, Aurora A, mitotic entry, and spindle bipolarity. Proc. Natl. Acad. Sci. USA 103, 5811-5816 (2006).
3. Y. Tao, P. Zhang, V. Frascogna, Y. Lecluse, A. Auperin, J. Bourhis and E. Deutsch, Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br. J. Cancer 97, 1664-1672 (2007).
4. G. Vader and S. M. Lens, The Aurora kinase family in cell division and cancer. Biochim. Biophys. Acta 1786, 60-72 (2008).
5. P. Melardi, R. Honda and E. A. Nigg, Aurora kinase links chromosome segregation and cell division to cancer susceptibility. Curr. Opin. Genet. Dev. 14, 29-36 (2004).
6. P. Briassouli, F. Chan, K. Savage, J. S. Reis-Filho and S. Linardopopulos, Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res. 67, 1689-1695 (2007).
7. S. Prajapati, Z. Tu, Y. Yammaoto and R. B. Gaynor, IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation. Cell Cycle 5, 2371-2380 (2006).
8. J. T. Irelan, T. J. Murphy, P. D. DeJesus, H. Teo, D. Xu, M. A. Gomez-Ferreria, Y. Zhou, L. J. Miraglia, D. R. Rines and S. K. Chanda, A role for IkappaB kinase 2 in bipolar spindle assembly Proc. Natl. Acad. Sci. USA 104, 16940-16945 (2007).
9. M. Karin and Y. Ben-Neriah, Phosphorylation meets ubiquitination: the control of NF-kB activity. Annu. Rev. Immunol. 18, 621-623 (2000).
10. P. Viatour, M. P. Merville, V. Bours and A. Chariot, Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem. Sci. 30, 43-52 (2005).
11. M. Karin, The IkappaB kinase-a bridge between inflammation and cancer. Cell Res. 18, 334-342 (2008).
12. M. Karin and F. R. Greten, NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759 (2005).
13. S. Ghosh and M. Karin, Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl.), S81-S96 (2002).
14. R. A. Baeuerle and D. Baltimore, NF-kappa B: ten years after. Cell 87, 13-20 (1996).
15. F. Chen, V. Castranova and X. Shi, New insights into the role of nuclear factor-kappaB in cell growth regulation. Am. J. Pathol. 159, 387-397 (2001).
16. G. Sethi, B. Sung and B. B. Aggarwal, Nuclear factor-kappaB activation: from bench to bedside. Exp. Biol. Med. 233, 21-31 (2008).
17. B. B. Aggarwal, Nuclear factor-kappaB: the enemy within. Cancer Cell 6, 203-208 (2004).
18. A. S. Baldwin, The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683 (1996).
19. E. Hertlein, J. Wang, K. J. Ladner, N. Bakkar and D. C. Guttridge, RelA/p65 regulation of IkBb. Mol. Cell. Biol. 25, 4956-4968 (2005).
20. Y. Habraken and J. Piette, NF-kappaB activation by double-strand breaks. Biochem. Pharmacol. 72, 1132-1141 (2006).
21. T. T. Huang, S. M. Wuerzberger-Davis, Z. H. Wu and S. Miyamoto, Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115, 565-576 (2003).
22. Z. H. Wu, Y. Shi, R. S. Tibbetts and S. Miyamoto, Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311, 1141-1146 (2006).
23. S. M. Wuerzberger-Davis, Y. Nakamura, B. J. Seufzer and S. Miyamoto, NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 26, 641-651 (2007).
24. V. Anest, J. L. Hanson, P. C. Cogswell, K. A. Steinbreacher, B. D. Strahl and A. S. Baldwin, A nucleosomal function for IKappaB kinase in NF-kappaB-dependent gene expression. Nature 423, 659-663 (2003).
25. C. J. Tang, C. Y. Lin and T. K. Tang, Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev. Biol. 290, 398-410 (2006).
26. L. Xiangyu, S. Gyosuke, M. Hideki, S. Kenji, K. Kenji, H. Fumio, T. Hisaaki, F. Koichi and U. Takeshi, Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. 279, 47201-47211 (2004).
27. J. D. Woronicz, X. Gao, Z. Cao, M. Roth and D. V. Goeddel, IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278, 866-869 (1997).
28. F. Mercurial, H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning and A. Rao, IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278, 860-866 (1997).
29. S. Yamaoka, G. Courtoise, C. Bessia, S. T. Whiteside, R. Weil, F. Aqou, H. E. Kirk, R. J. Kay and A. Israël, Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93, 1231-1240 (1998).
30. D. M. Rothwarf, E. Sandi, G. Natoli and M. Karin, IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395, 297-300 (1998).
31. Y. Hu, V. Baud, M. Delhase, P. Zhang, T. Derrick, M. Ellisman, R. Johnson and M. Karin, Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 284, 316-320 (1999).
32. Y. Yamamoto, U. N. Vera, S. Prajapati, Y. T. Kwan and R. B. Gaynor, Huston H3 phosphorylation by IKK-a is critical for cytokine-induced gene expression. Nature 423, 655-659 (2003).
33. C. B. Sun, F. Chan, P. Briassouli and S. Linardopoulos, Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents. Biochem. Biophys. Res. Commun. 352, 220-254 (2007).
34. X. X. Wang, R. Liu, S. Q. Jin, F. Y. Fan and Q. M. Zhan, Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res. 16, 356-366 (2006).
35. K. I. Jeon, J. Y. Jeong and D. M. Jue, Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. J. Immunol. 164,5981-5989 (2000).
36. J. Y. Jeong and D. M. Jue, Chloroquine inhibits processing of tumor necrosis factor in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Immunol. 158, 4901-4907 (1997).
37. A. Krystyniak, C. Garcia-Echeverria, C. Prigent and S. Ferrari, Inhibition of aurora A in response to DNA damage. Oncogene 25, 338-348 (2006).
38. T. Marumoto, T. Hirota, T. Morisaki, N. Kunitoku, D. Zhang, Y. Ichikawa, T. Sasayama, S. Kuninaka, T. Mimori and H. Saya, Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7, 1173-1182 (2002).