In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1797-1802

  Acharya, Jyotiranjan ^a   Dubey, Devendra Kumar ^a   Raza, Syed Kalbey ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

2 PAM; AChE; Bis pyridinium oximes; Nerve agents; Obidoxime; Reactivators

Indexed keywords

1,2 DIMETHOXY ETHYLENE BIS[3,3' (HYDROXYIMINOMETHYL) PYRIDINIUM] DICHLORIDE; 1,2 DIMETHOXY ETHYLENE BIS[4,4' (HYDROXYIMINOMETHYL) PYRIDINIUM] DICHLORIDE; ACETYLCHOLINESTERASE; BIS(PYRIDINIUM OXIME) DERIVATIVE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; SARIN; SOMAN; TABUN; UNCLASSIFIED DRUG;

ADSORPTION; ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; ERYTHROCYTE GHOST; HUMAN; HUMAN CELL; IN VITRO STUDY; PH; ULTRAVIOLET SPECTROSCOPY;

ADULT; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ERYTHROCYTE MEMBRANE; HUMANS; MALE; OBIDOXIME CHLORIDE; PRALIDOXIME COMPOUNDS; SARIN;

EID: 77956177926     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.06.013     Document Type: Article

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