Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase

Toxicology

Volumn 224, Issue 1-2, 2006, Pages 91-99

  Aurbek, N ^a   Thiermann, H ^a   Szinicz, L ^a   Eyer, P ^b   Worek, F ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetylcholinesterase; Aging; Human; Inhibition; Organophosphorus compounds; Oximes; Pig; Reactivation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; ERYTHROCYTE ENZYME; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NERVE GAS; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PRALIDOXIME; TOXIC GAS;

AGING; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEALKYLATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ERYTHROCYTE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SWINE; TOXICOKINETICS;

ACETYLCHOLINESTERASE; AGING; ALGORITHMS; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ENZYME ACTIVATION; ERYTHROCYTES; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; SPECIES SPECIFICITY; SWINE; SYNAPSES;

ANIMALIA; RODENTIA; SUS SCROFA;

EID: 33745220989     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.04.030     Document Type: Article

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