Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators

Biochemical Pharmacology

Volumn 72, Issue 3, 2006, Pages 358-365

  Eckert, Saskia ^a   Eyer, Peter ^a   Mückter, Harald ^a   Worek, Franz ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Bioreactor; Obidoxime; Paraoxon; Perfusion; Real time determination

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; OBIDOXIME; PARAOXON; SOLVENT;

ANALYTIC METHOD; ARTICLE; BATH; BIOLOGICAL MONITORING; BIOREACTOR; CALCULATION; CELL MANIPULATION; COMPUTER PROGRAM; CONCENTRATION RESPONSE; DRUG HALF LIFE; EFFLUENT; ENZYME ACTIVITY; ENZYME BINDING; ERYTHROCYTE; FILTER; FLOW KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYSTERESIS; IMMERSION; IMMOBILIZED CELL; IN VITRO STUDY; MEMBRANE BINDING; MOLECULAR DYNAMICS; MOLECULAR MIMICRY; MOLECULAR MODEL; PARTICULATE MATTER; PERFUSION; PRESSURE; PRIORITY JOURNAL; PUMP; QUANTITATIVE ANALYSIS; SIGNAL PROCESSING; TEMPERATURE; ULTRAVIOLET RADIATION;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CHROMOGENIC COMPOUNDS; COMPUTER SYSTEMS; DITHIONITROBENZOIC ACID; ENZYME STABILITY; EQUIPMENT DESIGN; ERYTHROCYTE MEMBRANE; HUMANS; OBIDOXIME CHLORIDE; PARAOXON; PERFUSION; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY; TEMPERATURE; TIME FACTORS;

EID: 33745642909     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.04.016     Document Type: Article

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