Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 2, 1997, Pages 325-332

  Lallement, Guy ^a,c   Clarencon, Didier ^b   Brochier, Guy ^a   Baubichon, Dominique ^a   Galonnier, Monique ^b   Blanchet, Guy ^d   Mestries, Jean Claude ^c  

^a Unité de Neurotoxicologie   (France)

^b Unité de Radioprotection   (France)

^c CENTRE DE RECHERCHES   (France)

^d DCSSA   (France)

Author keywords

atropine; diazepam; epilepsy; oximes; primates; soman

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ATROPINE; DIAZEPAM; PRALIDOXIME; PRODIAZEPAM; SOMAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPSY; HISTOLOGY; INTOXICATION; INTRAMUSCULAR DRUG ADMINISTRATION; LOCOMOTION; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIDOTES; ATROPINE; CHOLINESTERASE INHIBITORS; DIAZEPAM; DIPEPTIDES; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; MACACA FASCICULARIS; MALE; POISONING; PRALIDOXIME COMPOUNDS; PRODRUGS; PYRIDINIUM COMPOUNDS; SOMAN;

EID: 0031050175     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00292-4     Document Type: Article

References (21)

1. Carpentier, P.; Foquin-Tarricone, A.; Bodjarian, N.; Rondouin, G.; Lerner-Natoli, M.; Kamenka, J.M.; Blanchet, G.; Denoyer, M.; Lallement, G. Anticonvulsant and antilethal effects of the phencyclidine derivative TCP in soman poisoning. NeuroToxicology 15:837-852; 1994.
2. Clement, J. G.; Shiloff, J. D.; Gennings, C. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Arch. Toxicol. 61:70-75; 1987.
3. Clement, J. G.; Broxup, B. Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats. Neurotoxicology 14:485-504; 1993.
4. Dawson, R. M. Review of oximes available for treatment of nerve agent poisoning. J. Appl. Toxicol. 14:317-331; 1994.
5. Hamilton, M. G.; Lundy, P. M. HI-6 therapy of soman and tabun poisoning in primates and rodents. Arch. Toxicol. 63:144-149; 1989.
6. Hayward, I. J.; Wall, H. G.; Jaxx, N. K.; Wade, J. V.; Marlow D. D.; Nold, J. B. Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy. J. Neurol. Sci. 98:99-106; 1990.
7. Inns, R.H.; Leadbeater, L. The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea-pig. J. Pharm. Pharmacol. 35:427-433; 1983.
8. Koplovitz, I.; Gresham, V.C.; Kaminskis, A.; Stewart, J.R. Evaluation of the toxicity and treatment of GF poisoning in rhesus monkeys. Proc NATO Research Study Group 3 Panel VIII 632-643; 1991.
9. Kusic, R.; Boskovic, B.; Vojvodic, V.; Jovanovic, D. HI-6 in man: blood levels, urinary excretion, and tolerance after intramuscular administration of the oxime to healthy volunteers. Fundam. Appli. Toxicol. 5:S89-S97; 1985.
10. Lallement, G.; Delamanche, I. S.; Pernot-Marino, I.; Baubichon, D.; Denoyer, M.; Carpentier, P.; Blanchet, G. Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage:quantification with an w3 site ligand. Brain Res. 618:227-237; 1993.
11. Lallement, G.; Pernot-Marino, I.; Baubichon, D.; Burckhart, M.F; Carpentier, P.; Blanchet, G. Modulation of soman-induced neuropathology with an anticonvulsant regimen. NeuroReport 5:2265-2268; 1994.
12. Lallement, G.; Pernot-Marino, I.; Foquin-Tarricone, A.; Baubichon, D.; Piras, A.; Blanchet, G.; Carpentier, P. Coadministration of atropine, NBQX and TCP against soman-induced seizures. NeuroReport 5:1113-1117; 1994.
13. Lundy, P. M; Tremblay, K. P. Ganglion blocking properties of some bispyridinium soman antagonists. Euro. J. Pharmacol. 60:47-53; 1979.
14. Maidment, M. P.; Upshall, D. G. Pharmacokinetics of the conversion of a peptido-aminobenzophenone pro-drug of diazepam in guinea-pig and rhesus monkeys. J. Biopharm. Sci. 1:19-32; 1990.
15. McDonough, J. H.; Wayne Dochterman, L.; Smith, C. D; Shih, T. M. Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. NeuroToxicology 15:123-132; 1995.
16. Mestries, J. C.; Court, L.; Gourmelon, P.; Milhaud, C.; Breteau, J. Bioinstrumentation chronique chez le primate: application à l'évaluation des effets d'agents agressifs sur le système nerveux central. Sci. Tech. Anim. Lab. 9:35-46; 1984.
17. Mestries, J. C.; Court, L. Etude de la circulation cérébrale par une méthode chronique chez le macaque cynomolgus. S.S.A. Trav. Scient. 1:345-350; 1979.
18. Tryphonas, L.; Clement, J. G. Dose and time related effects on the CNS and heart of rats exposed to a single dose of soman: a histopathologic study. Med. Def. Biosci. Rev. 2:685-694; 1993.
19. Upshall, D. G.; Gouldstone, S. J.; Macey, N.; Maidment, M. P.; Wast, S. J.; Yeadon, M. Conversion of a peptido-aminobenzophenone pro-drug to diazepam in vitro, enzyme isolation and characterization. J. Biopharm. Sci. 1:111-126; 1990.
20. Van Helden, H. P. M.; Herman, P. M.; Van der Wiel, H. J.; De Lange, J.; Busker, R. W.; Melchers, B. P. C.; Wolthuis, O. L. Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys. Toxicol. Appl. Pharmacol. 115:50-56; 1992.
21. Von Bredow, J. D.; Maitland, G. F.; Adams, N. L.; Kaminskis, A.; Hayward, I. J.; Wall, H. G.; Jaax, N. K. Determination of the effectiveness of midazolam in preventing soman-induced convulsions and neuropathology in macaca fuscicularis USAMRICD-TR-90-14, AD A232017. US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 1990.