Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1482-1490

  Lu, Binan ^a   Hu, Mingming ^a   liu, Kexin ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Berberine; Drug targets; HeLa cells; In silico

Indexed keywords

BERBERINE; CASPASE 3; CASPASE 8; CYTOCHROME C; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TETRAZOLIUM; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR DOCKING; PREDICTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; BERBERINE; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION; HELA CELLS; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; RECEPTORS, DEATH DOMAIN; RNA, MESSENGER; TNF RECEPTOR-ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR-ALPHA; TUMOR STEM CELL ASSAY; UTERINE CERVICAL NEOPLASMS;

EID: 77956170866     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.07.017     Document Type: Article

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