Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Biochemical Pharmacology

Volumn 73, Issue 5, 2007, Pages 610-619

  Shiah, Her Shyong ^a   Lee, Wan Shu ^a   Juang, Shin Hun ^b,c   Hong, Pao Chiung ^b   Lung, Chia Chi ^a   Chang, Ching Jer ^d   Chou, Kai Ming ^e   Chang, Jang Yang ^a,f  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d PURDUE UNIVERSITY   (United States)

^e UNIVERSITY OF SOUTH ALABAMA   (United States)

^f TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Caspase; Mitochondria; p53; Selenophene derivative

Indexed keywords

2,5 BIS(5 HYDROXYMETHYL 2 SELENINYL) 3 HYDROXYMETHYL N METHYLPYRROLE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; D 501036; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN NOXA; PROTEIN P53; PROTEIN PUMA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOASSAY; CANCER CELL; CANCER INHIBITION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; ORGANOSELENIUM COMPOUNDS; PYRROLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33846518865     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.10.019     Document Type: Article

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