A solanesol-derived scaffold for multimerization of bioactive peptides

Journal of Organic Chemistry

Volumn 75, Issue 17, 2010, Pages 5895-5903

  Alleti, Ramesh ^a   Rao, Venkataramanarao ^a   Xu, Liping ^b   Gillies, Robert J ^b   Mash, Eugene A ^a  

^a University of Arizona   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZIDE-ALKYNE CYCLOADDITION; BINDING AFFINITIES; BIOACTIVE PEPTIDES; COMPETITIVE BINDING ASSAY; CONTROL STUDIES; HUMAN MELANOCORTIN-4 RECEPTOR (HMC4R); MOLECULAR SCAFFOLDS; MULTIMERIZATION; PROBE-BASED; SOLANESOL; SOLID PHASE SYNTHESIS; TERMINAL ALKYNE;

ACETYLENE; BEARINGS (STRUCTURAL); BINDING ENERGY; EUROPIUM; LIGANDS; PROBES; SCAFFOLDS; SYNTHESIS (CHEMICAL);

CHELATION;

2,2 BIS(3,7,11,15,19,23,27,31,35 NONAMETHYLHEXATRIACONTA 2,6,10,14,18,22,26,30,34 NONAENYL)PROPANE 1,3 DIOL; 37,37 BIS(HYDROXYMETHYL) 2,6,10,14,18,22,26,30,34,40,44,48,52,56,60,64,68,72 OCTADECAMETHYLTRIHEPTACONTAN 3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71 OCTADECAOL; 6 (4 BUTYL 1H 1,2,3 TRIAZOL 1 YL)HEXANOIC ACID; 6 AZIDOHEXANOIC ACID; ALKYNE; COPPER; DIMETHYL 2,2 BIS(3,7,11,15,19,23,27,31,35 NONAMETHYLHEXATRIACONTA 2,6,10,14,18,22,26,30,34 NONAENYL)MALONATE; LIGAND; MELANOCORTIN 4 RECEPTOR; MOLECULAR SCAFFOLD; N (1 AMINO 3 HYDROXY 1 OXOPROPAN 2 YL) 6 (4 BUTYL 1H 1,2,3 TRIAZOL 1 YL)HEXANAMIDE; N (1 AMINO 3 HYDROXY 1 OXOPROPAN 2 YL) 6 AZIDOHEXANAMIDE; ORGANIC COMPOUND; SOLANESOL; SOLANESYL BROMIDE; TRIAZOLE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL BOND; CONTROLLED STUDY; CYCLOADDITION; ENZYME MECHANISM; HUMAN; PROTEIN MULTIMERIZATION; SOLID PHASE SYNTHESIS; STATISTICAL SIGNIFICANCE;

ALKYNES; AZIDES; BINDING SITES; CATALYSIS; COPPER; CYCLIZATION; EUROPIUM; HUMANS; LIGANDS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PEPTIDES; RECEPTOR, MELANOCORTIN, TYPE 4; TERPENES;

EID: 77956148100     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101043m     Document Type: Article

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