Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2489-2492

  Xu, Liping ^a   Vagner, Josef ^b   Alleti, Ramesh ^c   Rao, Venkataramanarao ^c   Jagadish, Bhumasamudram ^c   Morse, David L ^a   Hruby, Victor J ^b,c   Gillies, Robert J ^a   Mash, Eugene A ^c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c University of Arizona   (United States)

Author keywords

Human melanocortin 4 receptor; MSH(4); Multimeric ligands; NDP MSH

Indexed keywords

EUROPIUM PENTETIC ACID 19 AMINO 5 OXO 3,10,13,16 TETRAOXA 6 AZANONADECAN 1 OIC ACID INTERMEDIN; INTERMEDIN DERIVATIVE; LIGAND; MELANOCORTIN 4 RECEPTOR; MULTIMERIC LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FOURIER TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; MASS SPECTROMETRY;

CELL CYCLE PROTEINS; EUROPIUM; HUMANS; PENTETIC ACID; RECEPTORS, MELANOCORTIN;

EID: 77950040225     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.007     Document Type: Article

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24. α-Fmoc amino acid, 3 equiv of HBTU, and 6 equiv of DIEA in DMF) for 3 h. If the second coupling did not result in a negative Kaiser test, the resin was washed with DMF and the remaining amino groups were capped using 50% acetic anhydride in pyridine for 10 min. When the coupling reaction was finished, the resin was washed with DMF, and the coupling procedure repeated for the next amino acid until all the amino acids in the sequence were attached.
25. 2+ 669.3; found 669.2.