Effects of linker length and flexibility on multivalent targeting

Biomacromolecules

Volumn 9, Issue 11, 2008, Pages 3057-3064

  Shewmake, Thomas A ^a,c   Solis, Francisco J ^a,b,c   Gillies, Robert J ^d   Caplan, Michael R ^a,b  

^a Arizona State University   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c ARIZONA STATE UNIVERSITY WEST   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; DRUG DELIVERY;

BINDING EVENTS; FLEXIBLE MODELS; LIGAND CONCENTRATIONS; LINKER FLEXIBILITIES; PEPTIDE LIGANDS; RANDOM COILS; RIGID RODS;

LIGANDS;

BINDING PROTEIN; CELL SURFACE RECEPTOR; LIGAND;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; LIGAND BINDING; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; RECEPTOR DENSITY;

CROSS-LINKING REAGENTS; DRUG DELIVERY SYSTEMS; LIGANDS; MODELS, THEORETICAL; PEPTIDES; PLIABILITY;

EID: 57049085220     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm800529b     Document Type: Article

References (33)

1. Braun, K.; Pipkom, R.; Waldeck, W. Development and characterization of drug delivery systems for targeting mammalian cells and tissues: A review. Curr. Med. Chem. 2005, 12 (16), 1841-58.
2. Neerman, M. F. Enhancing the site-specific targeting of macromolecular anticancer drug delivery systems. Curr. Drug Targets 2006, 7 (2), 229-35.
3. Reubi, J. C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev. 2003, 24 (4), 389-427.
4. Signore, A., Chianelli, M.; D'Alessandria, C.; Annovazzi, A. Receptor targeting agents for imaging inflammation/infection: Where are we now. Q. J. Nucl. Med. Mol. Imaging 2006, 50 (3), 236-42.
5. Vasir, J. K.; Labhasetwar, V. Targeted drug delivery in cancer therapy. Technol. Cancer Res. Treat. 2005, 4 (4), 363-74.
6. Wester, H. J.; Kessler, H. Molecular targeting with peptides or peptide-polymer conjugates: Just a question of size. J. Nucl. Med. 2005, 46 (12), 1940-5.
7. Gao, X.; Cui, Y.; Levenson, R. M.; Chung, L. W.; Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 2004, 22 (8), 969-76.
8. Rosca, E. V.; Stukel, J. M.; Gillies, R. J.; Vaper, J.; Caplan, M. R. Specificity and mobility of biomacromolecular, multivalent constructs for cellular targeting. Biomacromolecules 2007, 8 (12), 3830-5.
9. Handl, H. L.; Vagner, J.; Han, H.; Mash, E.; Hruby, V. J.; Gillies, R. J. Hitting multiple targets with multimeric ligands. Expert opin. Ther. Targets 2004, 8 (6), 565-86.
10. Kiessling, L. L.; Gestwicki, J. E.; Strong, L. E. Synthetic multivalent ligands in the exploration of cell-surface interactions. Curr. Opin. Chem. Biol. 2000, 4 (6), 696-703.
11. Kiessling, L. L.; Strong, L. E.; Gestwicki, J. E. Principles for multivalent ligand design. Annu. Rep. Med. Chem. 2000, 35, 321-330.
12. Manimen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem., Int. Ed. 1998, 37 (20), 2755-2794.
13. Whitesides, G. M.; Krishnamurthy, V. M. Designing ligands to bind proteins. Q. Rev. Biophys. 2005, 38 (4), 385-95.
14. Caplan, M. R.; Rosca, E. V. Targeting drugs to combinations of receptors: A modeling analysis of potential specificity. Arm Biomed. Eng. 2005, 33 (8), 1113-24.
15. Stukel, J. M.; Heys, J. J.; Caplan, M. R., Optimizing delivery of multivalent targeting constructs for detection of secondary tumors. Ann. Biomed. Eng. 2008, 36 (7), 1291-1304.
16. Gestwicki, J. E.; Cairo, C. W.; Strong, L. E.; Oetjen, K. A.; Kiessling, L. L. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. J. Am. Chem. Soc. 2002, 124 (50), 14922-33.
17. Gargano, J. M.; Ngo, T.; Kim, J. Y.; Acheson, D. W. K.; Lees, W. J. Multivalent inhibition of AB5 toxins. J. Am. Chem. Soc. 2001, 123, 12909-12910.
18. Krishnamurthy, V. M.; Semetey, V.; Bracher, P. J.; Shen, N.; Whitesides, G. M. Dependence of effective inolarity on linker length for an intramolecular protein-ligand system. J. Am. Chem. Soc. 2007, 129 (5), 1312-20.
19. Martin, J. I.; Zhang, C. Z.; Wang, Z. G. Polymer-tethered ligandreceptor interactions between surfaces. J. Polym. Sci., Part B: Polym. Phys. 2006, 44 (18), 2621-2637.
20. Moore, N. W.; Kuhl, T. L. The role of flexible tethers in multiple ligand-receptor bond formation between curved surfaces. Biophys. J. 2006, 91 (5), 1675-87.
21. Moreira, A. G.; Marques, C. M. The role of polymer spacers in specific adhesion. J. Chem. Phys. 2004, 120 (13), 6229-37.
22. Wong, J. Y.; Kuhl, T. L.; Israelachvili, J. N.; Mullah, N.; Zalipsky, S. Direct measurement of a tethered ligand-receptor interaction potential. Science 1997, 275 (5301), 820-2.
23. Jeppesen, C.; Wong, J. Y.; Kuhl, T. L.; Israelachvili, J. N.; Mullah, N.; Zalipsky, S.; Marques, C. M. Impact of polymer tether length on multiple ligand-receptor bond formation. Science 2001, 293 (5529), 465-8.
24. Kramer, R. H.; Karpen, J. W. Spanning binding sites on allosteric proteins with polymer-linked ligand dimers. Nature 1998, 395 (6703), 710-3.
25. Olivier, V.; Meisen, I.; Meckelein, B.; Hirst, T. R.; Peter-Katalinic, J.; Schmidt, M. A.; Frey, A. Influence of targeting ligand flexibility on receptor binding of particulate drug delivery systems. Bioconjugate Chem. 2003, 14 (6), 1203-8.
26. Vagner, J.; Handl, H. L.; Monguchi, Y.; Jana, U.; Begay, L. J.; Mash, E. A.; Hruby, V. J.; Gillies, R. J. Rigid linkers for bioactive peptides. Bioconjugate Chem. 2006, 17 (6), 1545-50.
27. Handl, H. L.; Sankaranarayanan, R.; Josan, J. S.; Vagner, J.; Mash, E. A.; Gillies, R. J.; Hruby, V. J. Synthesis and evaluation of bivalent NDP-α-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjugate Chem. 2007, 18 (4), 1101-9.
28. Handl, H. L.; Vagner, J.; Yamamura, H. I.; Hruby, V. J.; Gillies, R. J. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal. Biochem. 2004, 330 (2), 242-50.
29. Pal, S. K.; Pegram, M. HER2 targeted therapy in breast cancer. beyond Herceptin. Rev. Endocr. Metab. Disord. 2007, 8 (3), 269-77.
30. Starbuck, C.; Lauffenburger, D. A. Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotechnol. Prog. 1992, 8 (2), 132-43.
31. Sakhalkar, H. S.; Dalal, M. K.; Salem, A. K.; Ansari, R.; Fu, J.; Kiani, M. F.; Kudiaka, D. T.; Hanes, J.; Shakesheff, K. M.; Goetz, D. J. Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (26), 15895-900.
32. Kelso, B. G.; Caplan, M. R. Unpublished Data March 7, 2008.
33. Rosca, E. V.; Caplan, M. R. Glioblastoma targeting via receptors is concentration dependent. Biotechnol. Bioeng. 2008, submitted for publication.