Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain

Chemistry and Biology

Volumn 17, Issue 8, 2010, Pages 892-902

  Leonardi, Roberta ^a   Zhang, Yong Mei ^a,b   Yun, Mi Kyung ^a   Zhou, Ruobing ^a   Zeng, Fu Yue ^a,c   Lin, Wenwei ^a   Cui, Jimmy ^a   Chen, Taosheng ^a   Rock, Charles O ^a   White, Stephen W ^a   Jackowski, Suzanne ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

CHEMBIO; SIGNALING

Indexed keywords

2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2,4-THIAZOLIDINEDIONE; ACETYL COENZYME A; COENZYME A; ENZYME INHIBITOR; ISOENZYME; PANTOTHENATE KINASE; PHOSPHOTRANSFERASE; SULFONYLUREA DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING SITE; BIOSYNTHESIS; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ACETYL COENZYME A; ALLOSTERIC REGULATION; BINDING SITES; COENZYME A; ENZYME ACTIVATION; ENZYME INHIBITORS; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY; SULFONYLUREA COMPOUNDS; THIAZOLIDINEDIONES;

EID: 77956016293     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.06.006     Document Type: Article

References (35)

1. D.S. Bell Practical considerations and guidelines for dosing sulfonylureas as monotherapy or combination therapy Clin. Ther. 26 2004 1714 1727
2. K.A. Bode, M.G. Donner, I. Leier, and D. Keppler Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate Biochem. Pharmacol. 64 2002 151 158
3. A.E. Boyd, L. Aguilar-Bryan, and D.A. Nelson Molecular mechanisms of action of glyburide on the beta cell Am. J. Med. 89 1990 3S 10S
4. E.A. Gale Lessons from the glitazones: a story of drug development Lancet 357 2001 1870 1875
5. T.T. Gibbs, S.J. Russek, and D.H. Farb Sulfated steroids as endogenous neuromodulators Pharmacol. Biochem. Behav. 84 2006 555 567
6. M. Habig, A. Blechschmidt, S. Dressler, B. Hess, V. Patel, A. Billich, C. Ostermeier, D. Beer, and M. Klumpp Efficient elimination of nonstoichiometric enzyme inhibitors from HTS hit lists J. Biomol. Screen. 14 2009 679 689
7. H.S. Hansen, and T.A. Diep N-acylethanolamines, anandamide and food intake Biochem. Pharmacol. 78 2009 553 560
8. B.S. Hong, M.K. Yun, Y.-M. Zhang, S. Chohnan, C.O. Rock, S.W. White, S. Jackowski, H.W. Park, and R. Leonardi Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties Structure 14 2006 1251 1261
9. B.S. Hong, G. Senisterra, W.M. Rabeh, M. Vedadi, R. Leonardi, Y.M. Zhang, C.O. Rock, S. Jackowski, and H.W. Park Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder J. Biol. Chem. 282 2007 27984 27993
10. K. Hörtnagel, H. Prokisch, and T. Meitinger An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria Hum. Mol. Genet. 12 2003 321 327
11. M.W. Humble, S. Eykyn, and I. Phillips Staphylococcal bacteraemia, fusidic acid, and jaundice BMJ 280 1980 1495 1498
12. A.M. Lehane, R.V. Marchetti, C. Spry, D.A. van Schalkwyk, R. Teng, K. Kirk, and K.J. Saliba Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite J. Biol. Chem. 282 2007 25395 25405
13. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) J. Biol. Chem. 270 1995 12953 12956
14. R. Leonardi, S. Chohnan, Y.-M. Zhang, K.G. Virga, R.E. Lee, C.O. Rock, and S. Jackowski A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A J. Biol. Chem. 280 2005 3314 3322
15. R. Leonardi, Y.-M. Zhang, C.O. Rock, and S. Jackowski Coenzyme A: back in action Prog. Lipid Res. 44 2005 125 153
16. R. Leonardi, C.O. Rock, S. Jackowski, and Y.-M. Zhang Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine Proc. Natl. Acad. Sci. USA 104 2007 1494 1499
17. R. Leonardi, Y.M. Zhang, A. Lykidis, C.O. Rock, and S. Jackowski Localization and regulation of mouse pantothenate kinase 2 FEBS Lett. 581 2007 4639 4644
18. R. Leonardi, J.E. Rehg, C.O. Rock, and S. Jackowski Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state PLoS ONE 5 2010 e11107
19. S. Mudaliar, and R.R. Henry New oral therapies for type 2 diabetes mellitus: the glitazones or insulin sensitizers Annu. Rev. Med. 52 2001 239 257
20. M.J. Reginato, S.T. Bailey, S.L. Krakow, C. Minami, S. Ishii, H. Tanaka, and M.A. Lazar A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties J. Biol. Chem. 273 1998 32679 32684
21. C.O. Rock, M.A. Karim, Y.-M. Zhang, and S. Jackowski The murine Pank1 gene encodes two differentially regulated pantothenate kinase isozymes Gene 291 2002 35 43
22. C.O. Rock, H.-W. Park, and S. Jackowski Role of feedback regulation of pantothenate kinase (CoaA) in the control of coenzyme A levels in Escherichia coli J. Bacteriol. 185 2003 3410 3415
23. C. Sabatti, S.K. Service, A.L. Hartikainen, A. Pouta, S. Ripatti, J. Brodsky, C.G. Jones, N.A. Zaitlen, T. Varilo, and M. Kaakinen Genome-wide association analysis of metabolic traits in a birth cohort from a founder population Nat. Genet. 41 2009 35 46
24. G.J. Schwartz, J. Fu, G. Astarita, X. Li, S. Gaetani, P. Campolongo, V. Cuomo, and D. Piomelli The lipid messenger OEA links dietary fat intake to satiety Cell Metab. 8 2008 281 288
25. N.J. Smith, L.A. Stoddart, N.M. Devine, L. Jenkins, and G. Milligan The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1 J. Biol. Chem. 284 2009 17527 17539
26. W.-J. Song, and S. Jackowski Kinetics and regulation of pantothenate kinase from Escherichia coli J. Biol. Chem. 269 1994 27051 27058
27. C. Spry, D.A. van Schalkwyk, E. Strauss, and K.J. Saliba Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy Infect. Disord. Drug Targets 10 2010 200 216
28. M.L. Sznaidman, C.D. Haffner, P.R. Maloney, A. Fivush, E. Chao, D. Goreham, M.L. Sierra, C. LeGrumelec, H.E. Xu, and V.G. Montana Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) synthesis and biological activity Bioorg. Med. Chem. Lett. 13 2003 1517 1521
29. M. Vallee, W. Mayo, and M.M. Le Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging Brain Res. Brain Res. Rev. 37 2001 301 312
30. K.G. Virga, Y.-M. Zhang, R. Leonardi, R.A. Ivey, K. Hevener, H.-W. Park, S. Jackowski, C.O. Rock, and R.E. Lee Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors Bioorg. Med. Chem. 14 2006 1007 1020
31. M. Yun, C.-G. Park, J.-Y. Kim, C.O. Rock, S. Jackowski, and H.-W. Park Structural basis for the feedback regulation of Eschericia coli pantothenate kinase by coenzyme A J. Biol. Chem. 275 2000 28093 28099
32. J.H. Zhang, T.D. Chung, and K.R. Oldenburg A simple statistical parameter for use in evaluation and validation of high throughput screening assays J. Biomol. Screen. 4 1999 67 73
33. Y.-M. Zhang, C.O. Rock, and S. Jackowski Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters J. Biol. Chem. 280 2005 32594 32601
34. Y.M. Zhang, S. Chohnan, K.G. Virga, R.D. Stevens, O.R. Ilkayeva, B.R. Wenner, J.R. Bain, C.B. Newgard, R.E. Lee, C.O. Rock, and S. Jackowski Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis Chem. Biol. 14 2007 291 302
35. B. Zhou, S.K. Westaway, B. Levinson, M.A. Johnson, J. Gitschier, and S.J. Hayflick A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome Nat. Genet. 28 2001 345 349