Efficient elimination of nonstoichiometric enzyme inhibitors from HTS hit lists

Journal of Biomolecular Screening

Volumn 14, Issue 6, 2009, Pages 679-689

  Habig, Michael ^a   Blechschmidt, Anke ^a   Dressler, Sigmar ^a   Hess, Barbara ^a,c   Patel, Viral ^b   Billich, Andreas ^a   Ostermeier, Christian ^a   Beer, David ^b   Klumpp, Martin ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c ETH ZURICH   (Switzerland)

Author keywords

Enzyme; High throughput screening; Stoichiometric binding; Stoichiometric inhibitors

Indexed keywords

ENZYME INHIBITOR; PANTOTHENATE KINASE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1;

ARTICLE; CONCENTRATION RESPONSE; COST EFFECTIVENESS ANALYSIS; HIGH THROUGHPUT SCREENING; IC 50; LIGHT SCATTERING; MEASUREMENT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; RELIABILITY; STATISTICAL ANALYSIS; STOICHIOMETRY;

DETERGENTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; OCTOXYNOL; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STABILITY; REFERENCE STANDARDS; TEMPERATURE;

EID: 67651021179     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057109336586     Document Type: Article

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