Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6512-6525

  Örtqvist, Pernilla ^a   Gising, Johan ^a   Ehrenberg, Angelica E ^a   Vema, Aparna ^a   Borg, Anneli ^a   Karlén, Anders ^a   Larhed, Mats ^a   Danielson, U Helena ^a   Sandström, Anja ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

2(1H) pyrazinone; Hepatitis C virus NS3 protease; Phenylglycine; Protease inhibitors

Indexed keywords

ANTIVIRUS AGENT; GLYCINE; NONSTRUCTURAL PROTEIN 3; PHENYLGLYCINE; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HEPATITIS C VIRUS; MOLECULAR MODEL; NONHUMAN; WILD TYPE;

ANTIVIRAL AGENTS; BINDING SITES; DRUG DESIGN; HEPACIVIRUS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PROTEIN BINDING; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 77955985523     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.101     Document Type: Article

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