Structure-based design and synthesis of pyrazinones containing novel P 1 'side pocket' moieties as inhibitors of TF/VIIa

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 12, 2005, Pages 3006-3011

  Schweitzer, Barbara A ^a   Neumann, William L ^a   Rahman, Hayat K ^a   Kusturin, Carrie L ^a   Sample, Kirby R ^a   Poda, Gennadiy I ^a   Kurumbail, Ravi G ^a   Stevens, Anna M ^a   Stegeman, Roderick A ^a   Stallings, William C ^a   South, Michael S ^a  

^a PFIZER INC   (United States)

Author keywords

Pyrazinone; TFVIIa

Indexed keywords

BLOOD CLOTTING FACTOR 7A INHIBITOR; GLYCINE; HYDROGEN; LYSINE; PYRAZINONE; TISSUE FACTOR PATHWAY INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG INHIBITION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BENZAMIDINES; BINDING SITES; DRUG DESIGN; FACTOR VIIA; FIBRINOLYTIC AGENTS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN BINDING; PYRAZINES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944379122     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.037     Document Type: Article

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