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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 4, 2005, Pages 1173-1180

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors

(13) Han, Yongxin a Giroux, André a Colucci, John a Bayly, Christopher I a Mckay, Daniel J a Roy, Sophie a Xanthoudakis, Steve a Vaillancourt, John a Rasper, Dita M a Tam, John a Tawa, Paul a Nicholson, Donald W a Zamboni, Robert J a

a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

Caspase 3 inhibitors; Pyrazinone mono amide

Indexed keywords

CASPASE 3 INHIBITOR; MONOAMINE DERIVATIVE; PYRAZINOIC ACID DERIVATIVE;

APOPTOSIS; ARTICLE; CELL PROTECTION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN;

ANIMALIA;

EID: 20144389375 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.12.006 Document Type: Article

Times cited : (39)

References (32)

1
- 0032785021
- D.W. Nicholson Cell Death Differ. 6 1999 1028
- (1999) Cell Death Differ. , vol.6 , pp. 1028
- Nicholson, D.W.¹

2
- 0036205587
- Y. Shi Mol. Cell. 9 2002 459
- (2002) Mol. Cell. , vol.9 , pp. 459
- Shi, Y.¹

3
- 1642509582
- N.A. Thornberry, T.A. Rano, E.P. Peterson, D.M. Rasper, T. Timkey, M. Garcia-Calvo, V.M. Houtzager, P.A. Nordstrom, S. Rpy, K.T. Champman, and D.W. Nicholson J. Biol. Chem. 272 1997 11907
- (1997) J. Biol. Chem. , vol.272 , pp. 11907
- Thornberry, N.A.¹ Rano, T.A.² Peterson, E.P.³ Rasper, D.M.⁴ Timkey, T.⁵ Garcia-Calvo, M.⁶ Houtzager, V.M.⁷ Nordstrom, P.A.⁸ Rpy, S.⁹ Champman, K.T.¹⁰ Nicholson, D.W.¹¹

4
- 0035831473
- E.A. Slee, C. Adrain, and S.J. Martin J. Biol. Chem. 276 2001 7320
- (2001) J. Biol. Chem. , vol.276 , pp. 7320
- Slee, E.A.¹ Adrain, C.² Martin, S.J.³

5
- 0344142396
- A.G. Porter, and R.U. Janicke Cell Death Differ. 6 1999 99
- (1999) Cell Death Differ. , vol.6 , pp. 99
- Porter, A.G.¹ Janicke, R.U.²

6
- 0029956641
- K. Kuida, T.S. Zheng, S. Na, C. Kuan, D. Yang, H. Karasuyama, P. Rakic, and R.H. Flavell Nature 384 1996 368
- (1996) Nature , vol.384 , pp. 368
- Kuida, K.¹ Zheng, T.S.² Na, S.³ Kuan, C.⁴ Yang, D.⁵ Karasuyama, H.⁶ Rakic, P.⁷ Flavell, R.H.⁸

7
- 0034618635
- R.V. Talanian, K.D. Brady, and V.L. Cryns J. Med. Chem. 43 2000 3351
- (2000) J. Med. Chem. , vol.43 , pp. 3351
- Talanian, R.V.¹ Brady, K.D.² Cryns, V.L.³

8
- 5944251623
- R.S. Hotchkiss, K.C. Chang, P.E. Swanson, K.W. Tinsley, J.J. Hui, P. Klender, S. Xantoudakis, S. Roy, C. Black, E. Grimm, Y. Han, D.W. Nicholson, and I.E. Karl Nature Immun. 1 2000 496 and references cited therein
- (2000) Nature Immun. , vol.1 , pp. 496
- Hotchkiss, R.S.¹ Chang, K.C.² Swanson, P.E.³ Tinsley, K.W.⁴ Hui, J.J.⁵ Klender, P.⁶ Xantoudakis, S.⁷ Roy, S.⁸ Black, C.⁹ Grimm, E.¹⁰ Han, Y.¹¹ Nicholson, D.W.¹² Karl, I.E.¹³

9
- 0032080673
- Y. Cheng, M. Deshmukh, A. D'Costa, J.A. Demaro, J.M. Gidday, A. Shah, Y. Sun, M.F. Jacquin, E.M. Johnson, and D.M. Holtzman J. Clin. Invest. 101 1998 1992
- (1998) J. Clin. Invest. , vol.101 , pp. 1992
- Cheng, Y.¹ Deshmukh, M.² D'Costa, A.³ Demaro, J.A.⁴ Gidday, J.M.⁵ Shah, A.⁶ Sun, Y.⁷ Jacquin, M.F.⁸ Johnson, E.M.⁹ Holtzman, D.M.¹⁰

10
- 10744233764
- W. Yang, J. Guastella, J.-C. Huang, Y. Wang, L. Zhang, D. Xue, M. Tran, R. Woodward, S. Kasibhatla, B. Tseng, J. Drewe, and S.X. Cai Br. J. Pharmacol. 140 2003 402
- (2003) Br. J. Pharmacol. , vol.140 , pp. 402
- Yang, W.¹ Guastella, J.² Huang, J.-C.³ Wang, Y.⁴ Zhang, L.⁵ Xue, D.⁶ Tran, M.⁷ Woodward, R.⁸ Kasibhatla, S.⁹ Tseng, B.¹⁰ Drewe, J.¹¹ Cai, S.X.¹²

11
- 1242293893
- Y. Wang, J.-C. Huang, Z.-L. Zhou, W. Yang, J. Guastella, and S.X. Cai Bioorg. Med. Chem. Lett. 14 2004 1269 and references cited therein
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1269
- Wang, Y.¹ Huang, J.-C.² Zhou, Z.-L.³ Yang, W.⁴ Guastella, J.⁵ Cai, S.X.⁶

12
- 1242293893
- S.X. Cai, L. Guan, S. Jia, Y. Wang, W. Yang, and B. Tseng Bioorg. Med. Chem. Lett. 14 2004 1269
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1269
- Cai, S.X.¹ Guan, L.² Jia, S.³ Wang, Y.⁴ Yang, W.⁵ Tseng, B.⁶

13
- 0032898735
- P. Schotte, W. Declercq, S. van Huffel, P. Vandenabeele, and R. Beyaert FEBS Lett. 442 1999 117
- (1999) FEBS Lett. , vol.442 , pp. 117
- Schotte, P.¹ Declercq, W.² Van Huffel, S.³ Vandenabeele, P.⁴ Beyaert, R.⁵

14
- 10744225187
- E. Grimm, B. Roy, R. Aspiotis, C.J. Bayly, D.W. Nicholson, D.M. Rasper, J. Renaud, S. Roy, J. Tam, P. Tawa, J.P. Vaillancourt, S. Xanthoudakis, and R. Zamboni Bioorg. Med. Chem. 12 2004 845
- (2004) Bioorg. Med. Chem. , vol.12 , pp. 845
- Grimm, E.¹ Roy, B.² Aspiotis, R.³ Bayly, C.J.⁴ Nicholson, D.W.⁵ Rasper, D.M.⁶ Renaud, J.⁷ Roy, S.⁸ Tam, J.⁹ Tawa, P.¹⁰ Vaillancourt, J.P.¹¹ Xanthoudakis, S.¹² Zamboni, R.¹³

15
- 0014211618
- I. Schechter, and A. Berger Biochem. Biophys. Res. Commun. 27 1967 157
- (1967) Biochem. Biophys. Res. Commun. , vol.27 , pp. 157
- Schechter, I.¹ Berger, A.²

16
- 0034717269
- D. Lee, S.A. Long, J.L. Adams, G. Chan, K.S. Vaidya, T.A. Francis, K. Kirly, J.D. Winkler, C.-M. Sung, C. Debouck, S. Richardson, M.A. Levy, W.E. DeWolf Jr., P.M. Keller, T. Tomaszek, M.S. Head, M. Dominic Ryan, R. Curtis Haltiwanger, P.-H. Liang, C.A. Janson, P.J. McDevitt, K. Johanson, N.O. Concha, W. Chan, S.S. Abdel-Meguid, A.M. Badger, M.W. Lark, D.P. Nadeau, L.J. Suva, M. Gowen, and M.E. Nuttall J. Biol. Chem. 275 2000 16007
- (2000) J. Biol. Chem. , vol.275 , pp. 16007
- Lee, D.¹ Long, S.A.² Adams, J.L.³ Chan, G.⁴ Vaidya, K.S.⁵ Francis, T.A.⁶ Kirly, K.⁷ Winkler, J.D.⁸ Sung, C.-M.⁹ Debouck, C.¹⁰ Richardson, S.¹¹ Levy, M.A.¹² DeWolf Jr., W.E.¹³ Keller, P.M.¹⁴ Tomaszek, T.¹⁵ Head, M.S.¹⁶ Dominic Ryan, M.¹⁷ Curtis Haltiwanger, R.¹⁸ Liang, P.-H.¹⁹ Janson, C.A.²⁰ more..

17
- 1342314180
- Y. Han, A. Giroux, E. Grimm, R. Aspiotis, S. Francoeur, C.I. Bayly, D.J. McKay, S. Roy, S. Xanthoudakis, J.P. Vaillancourt, D.M. Rasper, J. Tam, P. Tawa, N.A. Thornberry, E.P. Paterson, M. Garcia-Calvo, J.W. Becher, J. Rotonda, D.W. Nicholson, and R.J. Zamboni Bioorg. Med. Chem. Lett. 14 2004 805
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 805
- Han, Y.¹ Giroux, A.² Grimm, E.³ Aspiotis, R.⁴ Francoeur, S.⁵ Bayly, C.I.⁶ McKay, D.J.⁷ Roy, S.⁸ Xanthoudakis, S.⁹ Vaillancourt, J.P.¹⁰ Rasper, D.M.¹¹ Tam, J.¹² Tawa, P.¹³ Thornberry, N.A.¹⁴ Paterson, E.P.¹⁵ Garcia-Calvo, M.¹⁶ Becher, J.W.¹⁷ Rotonda, J.¹⁸ Nicholson, D.W.¹⁹ Zamboni, R.J.²⁰ more..

18
- 15144357944
- P.E.J. Sanderson, T.A. Lyle, K.J. Cutrona, D.L. Dyer, B.D. Dorsey, C.M. McDonough, A.M. Naylor-Olson, I.-W. Chen, Z. Chen, J.J. Cook, C.M. Cooper, S.J. Gardell, T.R. Jare, J.A. Krueger, S. Dale Lewis, J.H. Lin, B.J. Lucas Jr., E.A. Lyle, J.J. Lynch Jr., M.T. Stranieri, K. Vastag, Y. Yan, J.A. Shafer, and J.P. Vacca J. Med. Chem. 41 1998 4466
- (1998) J. Med. Chem. , vol.41 , pp. 4466
- Sanderson, P.E.J.¹ Lyle, T.A.² Cutrona, K.J.³ Dyer, D.L.⁴ Dorsey, B.D.⁵ McDonough, C.M.⁶ Naylor-Olson, A.M.⁷ Chen, I.-W.⁸ Chen, Z.⁹ Cook, J.J.¹⁰ Cooper, C.M.¹¹ Gardell, S.J.¹² Jare, T.R.¹³ Krueger, J.A.¹⁴ Dale Lewis, S.¹⁵ Lin, J.H.¹⁶ Lucas Jr., B.J.¹⁷ Lyle, E.A.¹⁸ Lynch Jr., J.J.¹⁹ Stranieri, M.T.²⁰ more..

19
- 0033868166
- F.J. Fleitz, T.A. Lyle, N. Zheng, J.D. Armstrong III, and R.P. Volante Synth. Commun. 30 2000 3171
- (2000) Synth. Commun. , vol.30 , pp. 3171
- Fleitz, F.J.¹ Lyle, T.A.² Zheng, N.³ Armstrong III, J.D.⁴ Volante, R.P.⁵

20
- 0028167180
- R.E. Dolle, D. Hoyer, C.V.C. Prasad, S.J. Schmidt, C.T. Helaszek, R.E. Miller, and M.A. Ator J. Med. Chem. 37 1994 563
- (1994) J. Med. Chem. , vol.37 , pp. 563
- Dolle, R.E.¹ Hoyer, D.² Prasad, C.V.C.³ Schmidt, S.J.⁴ Helaszek, C.T.⁵ Miller, R.E.⁶ Ator, M.A.⁷

21
- 0031579968
- G. Semple, D.M. Ashworth, G.R. Baker, A.R. Batt, A.J. Baxter, D.W.M. Benzies, L.H. Elliot, D. Michael Evans, R.J. Franklin, P. Hudson, P.D. Jenkins, G.R. Pitt, D.P. Rooker, A.S. Sheppard, M. Szelke, S. Yamamoto, and Y. Isomura Bioorg. Med. Chem. Lett. 7 1997 1337
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 1337
- Semple, G.¹ Ashworth, D.M.² Baker, G.R.³ Batt, A.R.⁴ Baxter, A.J.⁵ Benzies, D.W.M.⁶ Elliot, L.H.⁷ Michael Evans, D.⁸ Franklin, R.J.⁹ Hudson, P.¹⁰ Jenkins, P.D.¹¹ Pitt, G.R.¹² Rooker, D.P.¹³ Sheppard, A.S.¹⁴ Szelke, M.¹⁵ Yamamoto, S.¹⁶ Isomura, Y.¹⁷

22
- 2342531089
- J.W. Becker, J. Rotonda, S.M. Soisson, R. Aspiotis, C.I. Bayly, S. Francoeur, M. Gallant, G.-C. Margarita, A. Giroux, E. Grimm, Y. Han, D. McKay, D.W. Nicholson, E. Paterson, J. Renaud, S. Roy, N. Thornberry, and R. Zamboni J. Med. Chem. 47 2004 2466 and references cited therein
- (2004) J. Med. Chem. , vol.47 , pp. 2466
- Becker, J.W.¹ Rotonda, J.² Soisson, S.M.³ Aspiotis, R.⁴ Bayly, C.I.⁵ Francoeur, S.⁶ Gallant, M.⁷ Margarita, G.-C.⁸ Giroux, A.⁹ Grimm, E.¹⁰ Han, Y.¹¹ McKay, D.¹² Nicholson, D.W.¹³ Paterson, E.¹⁴ Renaud, J.¹⁵ Roy, S.¹⁶ Thornberry, N.¹⁷ Zamboni, R.¹⁸

23
- 0038191724
- Abstracts of Papers, Boston, MA, USA, August 18-22
- Aspiotis, R.; Bayly, C. I.; Becker, J.; Ethier, D.; Francoeur, S.; Margarita, G.-C.; Giroux, A.; Grimm, E.; Han, Y.; McKay, D. J.; Nicholson, D. W.; Paterson, E.; Rasper, D.; Renaud, J.; Retonda, J.; Roy, S.; Tam, J.; Tawa, P.; Thornberry, N.; Vaillancourt, J.; Xanthoudakis, S.; Zamboni, R.; Abstracts of Papers, 224th ACS National Meeting, Boston, MA, USA, August 18-22, 2002
- (2002) 224th ACS National Meeting
- Aspiotis, R.¹ Bayly, C.I.² Becker, J.³ Ethier, D.⁴ Francoeur, S.⁵ Margarita, G.-C.⁶ Giroux, A.⁷ Grimm, E.⁸ Han, Y.⁹ McKay, D.J.¹⁰ Nicholson, D.W.¹¹ Paterson, E.¹² Rasper, D.¹³ Renaud, J.¹⁴ Retonda, J.¹⁵ Roy, S.¹⁶ Tam, J.¹⁷ Tawa, P.¹⁸ Thornberry, N.¹⁹ Vaillancourt, J.²⁰ Xanthoudakis, S.²¹ Zamboni, R.²² more..

24
- 15844393657
- J. Rotonda, D.W. Nicholson, K.M. Fazil, M. Gallant, Y. Gareau, M. Labelle, E.P. Peterson, D.M. Rasper, R. Ruel, J.P. Vaillancourt, N.A. Thornberry, and J.W. Becher Nat. Struct. Biol. 3 1996 619
- (1996) Nat. Struct. Biol. , vol.3 , pp. 619
- Rotonda, J.¹ Nicholson, D.W.² Fazil, K.M.³ Gallant, M.⁴ Gareau, Y.⁵ Labelle, M.⁶ Peterson, E.P.⁷ Rasper, D.M.⁸ Ruel, R.⁹ Vaillancourt, J.P.¹⁰ Thornberry, N.A.¹¹ Becher, J.W.¹²

25
- 0030948457
- R.V. Talanian, C. Quinlan, S. Trautz, M.C. Hackett, J.A. Mankovich, D. Banach, T. Ghayur, K.D. Brady, and W.W. Wong J. Biol. Chem. 272 1997 9677
- (1997) J. Biol. Chem. , vol.272 , pp. 9677
- Talanian, R.V.¹ Quinlan, C.² Trautz, S.³ Hackett, M.C.⁴ Mankovich, J.A.⁵ Banach, D.⁶ Ghayur, T.⁷ Brady, K.D.⁸ Wong, W.W.⁹

26
- 0344838392
- D. Chéreau, L. Kodandapani, K.J. Tomaselli, A.P. Spada, and J.C. Wu Biochemistry 42 2003 4151
- (2003) Biochemistry , vol.42 , pp. 4151
- Chéreau, D.¹ Kodandapani, L.² Tomaselli, K.J.³ Spada, A.P.⁴ Wu, J.C.⁵

27
- 20144387044
- G. Semple, D.M. Ashworth, A.R. Batt, A.J. Baxter, D.W.M. Benzies, L.H. Elliot, D. Michael Evans, R.J. Franklin, P. Hudson, P.D. Jenkins, G.R. Pitt, D.P. Rooker, S. Yamamoto, and Y. Isomura Bioorg. Med. Chem. Lett. 8 1998 1337
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 1337
- Semple, G.¹ Ashworth, D.M.² Batt, A.R.³ Baxter, A.J.⁴ Benzies, D.W.M.⁵ Elliot, L.H.⁶ Michael Evans, D.⁷ Franklin, R.J.⁸ Hudson, P.⁹ Jenkins, P.D.¹⁰ Pitt, G.R.¹¹ Rooker, D.P.¹² Yamamoto, S.¹³ Isomura, Y.¹⁴

28
- 0028314235
- M. Nakajima, K. Kashiwagi, J. Ohta, S. Furukawa, K. Hayashi, T. Kawashima, and Y. Hayashi Brain Res. 641 1994 350
- (1994) Brain Res. , vol.641 , pp. 350
- Nakajima, M.¹ Kashiwagi, K.² Ohta, J.³ Furukawa, S.⁴ Hayashi, K.⁵ Kawashima, T.⁶ Hayashi, Y.⁷

29
- 0242663945
- B.H. Han, D. Xu, J. Choi, Y. Han, S. Xanthoudakis, S. Roy, J. Tam, J. Vaillancourt, J. Colucci, R. Siman, A. Giroux, G.S. Robertson, R. Zamboni, D.W. Nicholson, and D.M. Holtzman J. Biol. Chem. 277 2002 30128
- (2002) J. Biol. Chem. , vol.277 , pp. 30128
- Han, B.H.¹ Xu, D.² Choi, J.³ Han, Y.⁴ Xanthoudakis, S.⁵ Roy, S.⁶ Tam, J.⁷ Vaillancourt, J.⁸ Colucci, J.⁹ Siman, R.¹⁰ Giroux, A.¹¹ Robertson, G.S.¹² Zamboni, R.¹³ Nicholson, D.W.¹⁴ Holtzman, D.M.¹⁵

30
- 4544234691
- S. Toulmond, K. Tang, Y. Bureau, H. Ashdown, S. Degen, R. O'Donnell, J. Tam, Y. Han, J. Colucci, A. Giroux, Y. Zhu, M. Boucher, B. Pikounis, S. Xanthoudakis, S. Roy, M. Rigby, R. Zamboni, G.S. Robertson, G.Y.K. Ng, D.W. Nicholson, and J.-P. Flückiger Br. J. Pharmacol. 141 2004 689
- (2004) Br. J. Pharmacol. , vol.141 , pp. 689
- Toulmond, S.¹ Tang, K.² Bureau, Y.³ Ashdown, H.⁴ Degen, S.⁵ O'Donnell, R.⁶ Tam, J.⁷ Han, Y.⁸ Colucci, J.⁹ Giroux, A.¹⁰ Zhu, Y.¹¹ Boucher, M.¹² Pikounis, B.¹³ Xanthoudakis, S.¹⁴ Roy, S.¹⁵ Rigby, M.¹⁶ Zamboni, R.¹⁷ Robertson, G.S.¹⁸ Ng, G.Y.K.¹⁹ Nicholson, D.W.²⁰ Flückiger, J.-P.²¹ more..

31
- 1642500084
- N. Méthot, J. Huang, N. Coulombe, J.P. Vaillancourt, D. Rasper, J. Tam, Y. Han, J. Colucci, R. Zamboni, S. Xanthoudakis, S. Toulmond, D.W. Nicholson, and S. Roy J. Exp. Med. 199 2004 199
- (2004) J. Exp. Med. , vol.199 , pp. 199
- Méthot, N.¹ Huang, J.² Coulombe, N.³ Vaillancourt, J.P.⁴ Rasper, D.⁵ Tam, J.⁶ Han, Y.⁷ Colucci, J.⁸ Zamboni, R.⁹ Xanthoudakis, S.¹⁰ Toulmond, S.¹¹ Nicholson, D.W.¹² Roy, S.¹³

32
- 3142616523
- N. Méthot, J.P. Vaillancourt, J.Q. Huang, J. Colucci, Y. Han, S. Menard, R. Zamboni, S. Toulmond, D.W. Nicholson, and S. Roy J. Biol. Chem. 279 2004 27905
- (2004) J. Biol. Chem. , vol.279 , pp. 27905
- Méthot, N.¹ Vaillancourt, J.P.² Huang, J.Q.³ Colucci, J.⁴ Han, Y.⁵ Menard, S.⁶ Zamboni, R.⁷ Toulmond, S.⁸ Nicholson, D.W.⁹ Roy, S.¹⁰

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