Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1671-1674

  Isabel, Elise ^a   Aspiotis, Renee ^a   Black, W Cameron ^a   Colucci, John ^a   Fortin, Réjean ^a   Giroux, André ^a   Grimm, Erich L ^a   Han, Yongxin ^a   Mellon, Christophe ^a   Nicholson, Donald W ^a   Rasper, Dita M ^a   Renaud, Johanne ^a   Roy, Sophie ^a   Tam, John ^a   Tawa, Paul ^a   Vaillancourt, John P ^a   Xanthoudakis, Steven ^a   Zamboni, Robert J ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Caspase; Palladium catalyzed amination; Pyrazinone

Indexed keywords

3 BROMOPYRAZINONE DERIVATIVE; CASPASE 3 INHIBITOR; PALLADIUM; UNCLASSIFIED DRUG;

AMINATION; APOPTOSIS; ARTICLE; CATALYSIS; DEGENERATIVE DISEASE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; SOLID;

AMINATION; CASPASE 3; CATALYSIS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; PALLADIUM; PROTEASE INHIBITORS; PYRAZINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847037380     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.110     Document Type: Article

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