Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5413-5424

  Lampa, Anna ^a   Ehrenberg, Angelica E ^a   Gustafsson, Sofia S ^a   Vema, Aparna ^a   Åkerblom, Eva ^a   Lindeberg, Gunnar ^a   Karlén, Anders ^a   Danielson, U Helena ^a   Sandström, Anja ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alkenylic acylsulfonamides; HCV; Peptidomimetics; Phenylglycine; Protease inhibitors; Resistance

Indexed keywords

ALKENYL GROUP; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 3; PHENYLGLYCINE; PROTEINASE INHIBITOR; VINYL DERIVATIVE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; EPIMER; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; GLYCINE; HEPACIVIRUS; HEPATITIS C; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 77955314517     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.027     Document Type: Article

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