-
1
-
-
67649586663
-
Extracellular norepinephrine, norepinephrine receptor and transporter protein and mRNA levels are differentially altered in the developing rat brain due to dietary iron deficiency and manganese exposure
-
Anderson, J., Fordahl, S., Cooney, P., Weaver, T., Colyer, C., and Erikson, K. (2009). Extracellular norepinephrine, norepinephrine receptor and transporter protein and mRNA levels are differentially altered in the developing rat brain due to dietary iron deficiency and manganese exposure. Brain Res. 1281, 1-14.
-
(2009)
Brain Res
, vol.1281
, pp. 1-14
-
-
Anderson, J.1
Fordahl, S.2
Cooney, P.3
Weaver, T.4
Colyer, C.5
Erikson, K.6
-
2
-
-
0035155759
-
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP
-
Andreassen, O., Ferrante, R., Dedeoglu, A., Albers, D., Klivenyi, P., Carlson, E., Epstein, C., and Beal, M. (2001). Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Exp. Neurol. 167, 189-195.
-
(2001)
Exp. Neurol.
, vol.167
, pp. 189-195
-
-
Andreassen, O.1
Ferrante, R.2
Dedeoglu, A.3
Albers, D.4
Klivenyi, P.5
Carlson, E.6
Epstein, C.7
Beal, M.8
-
3
-
-
0014940473
-
Phosphate binding to alkaline phosphatase. Metal ion dependence
-
Applebury, M., Johnson, B., and Coleman, J. (1970). Phosphate binding to alkaline phosphatase. Metal ion dependence. J. Biol. Chem. 245, 4968-4976.
-
(1970)
J. Biol. Chem.
, vol.245
, pp. 4968-4976
-
-
Applebury, M.1
Johnson, B.2
Coleman, J.3
-
4
-
-
13144276277
-
Manganese dosimetry: species differences and implications for neurotoxicity
-
Aschner, M., Erikson, K., and Dorman, D. (2005). Manganese dosimetry: species differences and implications for neurotoxicity. Crit. Rev. Toxicol. 35, 1-32.
-
(2005)
Crit. Rev. Toxicol.
, vol.35
, pp. 1-32
-
-
Aschner, M.1
Erikson, K.2
Dorman, D.3
-
5
-
-
0028366603
-
Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms
-
Aschner, M., and Gannon, M. (1994). Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res. Bull. 33, 345-349.
-
(1994)
Brain Res. Bull.
, vol.33
, pp. 345-349
-
-
Aschner, M.1
Gannon, M.2
-
6
-
-
34248999831
-
Manganese: recent advances in understanding its transport and neurotoxicity
-
Aschner, M., Guilarte, T., Schneider, J., and Zheng, W. (2007). Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol. Appl. Pharmacol. 221, 131-147.
-
(2007)
Toxicol. Appl. Pharmacol.
, vol.221
, pp. 131-147
-
-
Aschner, M.1
Guilarte, T.2
Schneider, J.3
Zheng, W.4
-
7
-
-
0032890824
-
Increased basal ganglia iron levels in Huntington disease
-
Bartzokis, G., Cummings, J., Perlman, S., Hance, D., and Mintz, J. (1999). Increased basal ganglia iron levels in Huntington disease. Arch. Neurol. 56, 569-574.
-
(1999)
Arch. Neurol.
, vol.56
, pp. 569-574
-
-
Bartzokis, G.1
Cummings, J.2
Perlman, S.3
Hance, D.4
Mintz, J.5
-
8
-
-
0027433553
-
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
-
Beal, M., Brouillet, E., Jenkins, B., Ferrante, R., Kowall, N., Miller, J., Storey, E., Srivastava, R., Rosen, B., and Hyman, B. (1993). Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13, 4181-4192.
-
(1993)
J. Neurosci.
, vol.13
, pp. 4181-4192
-
-
Beal, M.1
Brouillet, E.2
Jenkins, B.3
Ferrante, R.4
Kowall, N.5
Miller, J.6
Storey, E.7
Srivastava, R.8
Rosen, B.9
Hyman, B.10
-
9
-
-
3142596164
-
Molecular pathways to neurodegeneration
-
Bossy-Wetzel, E., Schwarzenbacher, R., and Lipton, S. (2004). Molecular pathways to neurodegeneration. Nat. Med. 10(Suppl.), S2-S9.
-
(2004)
Nat. Med.
, vol.10
, Issue.SUPPL
-
-
Bossy-Wetzel, E.1
Schwarzenbacher, R.2
Lipton, S.3
-
10
-
-
25844524877
-
Neurodegenerative diseases: an overview of environmental risk factors
-
Brown, R., Lockwood, A., and Sonawane, B. (2005). Neurodegenerative diseases: an overview of environmental risk factors. Environ. Health Perspect. 113, 1250-1256.
-
(2005)
Environ. Health Perspect.
, vol.113
, pp. 1250-1256
-
-
Brown, R.1
Lockwood, A.2
Sonawane, B.3
-
11
-
-
0022920920
-
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus
-
Butterworth, J. (1986). Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus. J. Neurochem. 47, 583-587.
-
(1986)
J. Neurochem.
, vol.47
, pp. 583-587
-
-
Butterworth, J.1
-
12
-
-
0019872426
-
Loss of glutamine synthetase activity in the brain in Huntington's disease
-
Carter, C. (1981). Loss of glutamine synthetase activity in the brain in Huntington's disease. Lancet 1, 782-783.
-
(1981)
Lancet
, vol.1
, pp. 782-783
-
-
Carter, C.1
-
13
-
-
34047184385
-
Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease
-
Chiang, M., Chen, H., Lee, Y., Chang, H., Wu, Y., Soong, B., Chen, C., Wu, Y., Liu, C., Niu, D., et al. (2007). Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum. Mol. Genet. 16, 483-498.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 483-498
-
-
Chiang, M.1
Chen, H.2
Lee, Y.3
Chang, H.4
Wu, Y.5
Soong, B.6
Chen, C.7
Wu, Y.8
Liu, C.9
Niu, D.10
-
14
-
-
77954079854
-
Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease
-
Choi, C. J., Anantharam, V., Martin, D. P., Nicholson, E. M., Richt, J. A., Kanthasamy, A., and Kanthasamy, A. G. (2010). Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease. Toxicol. Sci. 115, 535-546.
-
(2010)
Toxicol. Sci.
, vol.115
, pp. 535-546
-
-
Choi, C.J.1
Anantharam, V.2
Martin, D.P.3
Nicholson, E.M.4
Richt, J.A.5
Kanthasamy, A.6
Kanthasamy, A.G.7
-
15
-
-
34547839621
-
Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death
-
Choi, C. J., Anantharam, V., Saetveit, N. J., Houk, R. S., Kanthasamy, A., and Kanthasamy, A. G. (2007). Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicol. Sci. 98, 495-509.
-
(2007)
Toxicol. Sci.
, vol.98
, pp. 495-509
-
-
Choi, C.J.1
Anantharam, V.2
Saetveit, N.J.3
Houk, R.S.4
Kanthasamy, A.5
Kanthasamy, A.G.6
-
16
-
-
33747164172
-
Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases
-
Choi, C. J., Kanthasamy, A., Anantharam, V., and Kanthasamy, A. G. (2006). Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology 27, 777-787.
-
(2006)
Neurotoxicology
, vol.27
, pp. 777-787
-
-
Choi, C.J.1
Kanthasamy, A.2
Anantharam, V.3
Kanthasamy, A.G.4
-
17
-
-
33750910721
-
Genes and the environment in neurodegeneration
-
Coppede, F., Mancuso, M., Siciliano, G., Migliore, L., and Murri, L. (2006). Genes and the environment in neurodegeneration. Biosci. Rep. 26, 341-367.
-
(2006)
Biosci. Rep.
, vol.26
, pp. 341-367
-
-
Coppede, F.1
Mancuso, M.2
Siciliano, G.3
Migliore, L.4
Murri, L.5
-
18
-
-
0034941118
-
Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease
-
Curtis, A., Fey, C., Morris, C., Bindoff, L., Ince, P., Chinnery, P., Coulthard, A., Jackson, M., Jackson, A., McHale, D., et al. (2001). Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Nat. Genet. 28, 350-354.
-
(2001)
Nat. Genet.
, vol.28
, pp. 350-354
-
-
Curtis, A.1
Fey, C.2
Morris, C.3
Bindoff, L.4
Ince, P.5
Chinnery, P.6
Coulthard, A.7
Jackson, M.8
Jackson, A.9
McHale, D.10
-
19
-
-
71949108518
-
Mitochondria in Huntington's disease
-
Damiano, M., Galvan, L., Déglon, N., and Brouillet, E. (2010). Mitochondria in Huntington's disease. Biochim. Biophys. Acta 1802, 52-61.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, pp. 52-61
-
-
Damiano, M.1
Galvan, L.2
Déglon, N.3
Brouillet, E.4
-
20
-
-
0025821265
-
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
-
Dexter, D., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F., Daniel, S., Lees, A., Jenner, P., and Marsden, C. (1991). Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114(Pt 4), 1953-1975.
-
(1991)
Brain
, vol.114
, Issue.PT 4
, pp. 1953-1975
-
-
Dexter, D.1
Carayon, A.2
Javoy-Agid, F.3
Agid, Y.4
Wells, F.5
Daniel, S.6
Lees, A.7
Jenner, P.8
Marsden, C.9
-
21
-
-
34249715905
-
In vitro methods for detecting cytotoxicity
-
Ehrich, M., and Sharova, L. (2000). In vitro methods for detecting cytotoxicity. Curr. Protoc. Toxicol. 3, 6.2.11-6.2.12.
-
(2000)
Curr. Protoc. Toxicol.
, vol.3
-
-
Ehrich, M.1
Sharova, L.2
-
22
-
-
38449093605
-
Glutamate and astrocytes-key players in human mesial temporal lobe epilepsy?
-
Eid, T., Williamson, A., Lee, T., Petroff, O., and de Lanerolle, N. (2008). Glutamate and astrocytes-key players in human mesial temporal lobe epilepsy? Epilepsia 49(Suppl. 2), 42-52.
-
(2008)
Epilepsia
, vol.49
, Issue.SUPPL. 2
, pp. 42-52
-
-
Eid, T.1
Williamson, A.2
Lee, T.3
Petroff, O.4
de Lanerolle, N.5
-
23
-
-
10044233909
-
Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta
-
Ensunsa, J., Symons, J., Lanoue, L., Schrader, H., and Keen, C. (2004). Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Exp. Biol. Med. 229, 1143-1153.
-
(2004)
Exp. Biol. Med.
, vol.229
, pp. 1143-1153
-
-
Ensunsa, J.1
Symons, J.2
Lanoue, L.3
Schrader, H.4
Keen, C.5
-
24
-
-
28544449476
-
Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter
-
Erikson, K., and Aschner, M. (2006). Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27, 125-130.
-
(2006)
Neurotoxicology
, vol.27
, pp. 125-130
-
-
Erikson, K.1
Aschner, M.2
-
25
-
-
0035986114
-
Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations
-
Erikson, K., Shihabi, Z., Aschner, J., and Aschner, M. (2002). Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol. Trace Elem. Res. 87, 143-156.
-
(2002)
Biol. Trace Elem. Res.
, vol.87
, pp. 143-156
-
-
Erikson, K.1
Shihabi, Z.2
Aschner, J.3
Aschner, M.4
-
26
-
-
2442423090
-
Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency
-
Erikson, K., Syversen, T., Steinnes, E., and Aschner, M. (2004). Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J. Nutr. Biochem. 15, 335-341.
-
(2004)
J. Nutr. Biochem.
, vol.15
, pp. 335-341
-
-
Erikson, K.1
Syversen, T.2
Steinnes, E.3
Aschner, M.4
-
27
-
-
37249083913
-
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease
-
Fernandes, H., Baimbridge, K., Church, J., Hayden, M., and Raymond, L. (2007). Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease. J. Neurosci. 27, 13614-13623.
-
(2007)
J. Neurosci.
, vol.27
, pp. 13614-13623
-
-
Fernandes, H.1
Baimbridge, K.2
Church, J.3
Hayden, M.4
Raymond, L.5
-
28
-
-
33751080354
-
Huntingtin inclusion bodies are iron-dependent centers of oxidative events
-
Firdaus, W., Wyttenbach, A., Giuliano, P., Kretz-Remy, C., Currie, R., and Arrigo, A. (2006). Huntingtin inclusion bodies are iron-dependent centers of oxidative events. FEBS J. 273, 5428-5441.
-
(2006)
FEBS J
, vol.273
, pp. 5428-5441
-
-
Firdaus, W.1
Wyttenbach, A.2
Giuliano, P.3
Kretz-Remy, C.4
Currie, R.5
Arrigo, A.6
-
29
-
-
42149094924
-
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging
-
Fitsanakis, V., Zhang, N., Anderson, J., Erikson, K., Avison, M., Gore, J., and Aschner, M. (2008). Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging. Toxicol. Sci. 103, 116-124.
-
(2008)
Toxicol. Sci.
, vol.103
, pp. 116-124
-
-
Fitsanakis, V.1
Zhang, N.2
Anderson, J.3
Erikson, K.4
Avison, M.5
Gore, J.6
Aschner, M.7
-
30
-
-
0032477866
-
Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
-
Fleming, M., Romano, M., Su, M., Garrick, L., Garrick, M., and Andrews, N. (1998). Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. U.S.A. 95, 1148-1153.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 1148-1153
-
-
Fleming, M.1
Romano, M.2
Su, M.3
Garrick, L.4
Garrick, M.5
Andrews, N.6
-
31
-
-
55349106939
-
Mechanisms of copper ion mediated Huntington's disease progression
-
Fox, J. H., Kama, J. A., Lieberman, G., Chopra, R., Dorsey, K., Chopra, V., Volitakis, I., Cherny, R. A., Bush, A. I., and Hersch, S. (2007). Mechanisms of copper ion mediated Huntington's disease progression. PLoS One 2, e334.
-
(2007)
PLoS One
, vol.2
-
-
Fox, J.H.1
Kama, J.A.2
Lieberman, G.3
Chopra, R.4
Dorsey, K.5
Chopra, V.6
Volitakis, I.7
Cherny, R.A.8
Bush, A.I.9
Hersch, S.10
-
32
-
-
33745801577
-
A manganeseenhanced diet alters brain metals and transporters in the developing rat
-
Garcia, S., Gellein, K., Syversen, T., and Aschner, M. (2006). A manganeseenhanced diet alters brain metals and transporters in the developing rat. Toxicol. Sci. 92, 516-525.
-
(2006)
Toxicol. Sci.
, vol.92
, pp. 516-525
-
-
Garcia, S.1
Gellein, K.2
Syversen, T.3
Aschner, M.4
-
33
-
-
33845657881
-
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain
-
Garcia, S., Gellein, K., Syversen, T., and Aschner, M. (2007). Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol. Sci. 95, 205-214.
-
(2007)
Toxicol. Sci.
, vol.95
, pp. 205-214
-
-
Garcia, S.1
Gellein, K.2
Syversen, T.3
Aschner, M.4
-
34
-
-
42449154695
-
Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter
-
Girijashanker, K., He, L., Soleimani, M., Reed, J., Li, H., Liu, Z., Wang, B., Dalton, T., and Nebert, D. (2008). Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol. Pharmacol. 73, 1413-1423.
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 1413-1423
-
-
Girijashanker, K.1
He, L.2
Soleimani, M.3
Reed, J.4
Li, H.5
Liu, Z.6
Wang, B.7
Dalton, T.8
Nebert, D.9
-
35
-
-
61349147706
-
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
-
Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J., Caldwell, K. A., Caldwell, G. A., Cooper, A. A., Rochet, J.-C., et al. (2009). Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat. Genet. 41, 308-315.
-
(2009)
Nat. Genet.
, vol.41
, pp. 308-315
-
-
Gitler, A.D.1
Chesi, A.2
Geddie, M.L.3
Strathearn, K.E.4
Hamamichi, S.5
Hill, K.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Cooper, A.A.9
Rochet, J.-C.10
-
36
-
-
57749098786
-
Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport
-
Goytain, A., Hines, R. M., and Quamme, G. A. (2008). Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. J. Biol. Chem. 283, 33365-33374.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33365-33374
-
-
Goytain, A.1
Hines, R.M.2
Quamme, G.A.3
-
37
-
-
33745003424
-
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
-
Graham, R., Deng, Y., Slow, E., Haigh, B., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Bertram, L., Murphy, Z., et al. (2006). Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125, 1179-1191.
-
(2006)
Cell
, vol.125
, pp. 1179-1191
-
-
Graham, R.1
Deng, Y.2
Slow, E.3
Haigh, B.4
Bissada, N.5
Lu, G.6
Pearson, J.7
Shehadeh, J.8
Bertram, L.9
Murphy, Z.10
-
38
-
-
60849093185
-
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease
-
Graham, R., Pouladi, M., Joshi, P., Lu, G., Deng, Y., Wu, N., Figueroa, B., Metzler, M., Andre, V., Slow, E., et al. (2009). Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. J. Neurosci. 29, 2193-2204.
-
(2009)
J. Neurosci.
, vol.29
, pp. 2193-2204
-
-
Graham, R.1
Pouladi, M.2
Joshi, P.3
Lu, G.4
Deng, Y.5
Wu, N.6
Figueroa, B.7
Metzler, M.8
Andre, V.9
Slow, E.10
-
39
-
-
0033000638
-
Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers
-
Greger, J. (1999). Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers. Neurotoxicology 20, 205-212.
-
(1999)
Neurotoxicology
, vol.20
, pp. 205-212
-
-
Greger, J.1
-
40
-
-
18244389488
-
Iron-dependent regulation of the divalent metal ion transporter
-
Gunshin, H., Allerson, C., Polycarpou-Schwarz, M., Rofts, A., Rogers, J., Kishi, F., Hentze, M., Rouault, T., Andrews, N., and Hediger, M. (2001). Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509, 309-316.
-
(2001)
FEBS Lett
, vol.509
, pp. 309-316
-
-
Gunshin, H.1
Allerson, C.2
Polycarpou-Schwarz, M.3
Rofts, A.4
Rogers, J.5
Kishi, F.6
Hentze, M.7
Rouault, T.8
Andrews, N.9
Hediger, M.10
-
41
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin, H., Mackenzie, B., Berger, U., Gunshin, Y., Romero, M., Boron, W., Nussberger, S., Gollan, J., and Hediger, M. (1997). Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488.
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
Mackenzie, B.2
Berger, U.3
Gunshin, Y.4
Romero, M.5
Boron, W.6
Nussberger, S.7
Gollan, J.8
Hediger, M.9
-
42
-
-
33745249951
-
ZIP8, member of the solute-carrier-39 (SLC39) metaltransporter family: characterization of transporter properties
-
He, L., Girijashanker, K., Dalton, T., Reed, J., Li, H., Soleimani, M., and Nebert, D. (2006). ZIP8, member of the solute-carrier-39 (SLC39) metaltransporter family: characterization of transporter properties. Mol. Pharmacol. 70, 171-180.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 171-180
-
-
He, L.1
Girijashanker, K.2
Dalton, T.3
Reed, J.4
Li, H.5
Soleimani, M.6
Nebert, D.7
-
43
-
-
63849154126
-
In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease
-
Heng, M. Y., Detloff, P. J., Wang, P. L., Tsien, J. Z., and Albin, R. L. (2009). In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. J. Neurosci. 29, 3200-3205.
-
(2009)
J. Neurosci.
, vol.29
, pp. 3200-3205
-
-
Heng, M.Y.1
Detloff, P.J.2
Wang, P.L.3
Tsien, J.Z.4
Albin, R.L.5
-
44
-
-
0034703860
-
Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles
-
Hilditch-Maguire, P., Trettel, F., Passani, L., Auerbach, A., Persichetti, F., and MacDonald, M. (2000). Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum. Mol. Genet. 9, 2789-2797.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2789-2797
-
-
Hilditch-Maguire, P.1
Trettel, F.2
Passani, L.3
Auerbach, A.4
Persichetti, F.5
MacDonald, M.6
-
45
-
-
0014953355
-
Binding of manganese and transferrin in rat serum
-
Keefer, R. C., Barak, A. J., and Boyett, J. D. (1970). Binding of manganese and transferrin in rat serum. Biochim. Biophys. Acta 221, 390-393.
-
(1970)
Biochim. Biophys. Acta
, vol.221
, pp. 390-393
-
-
Keefer, R.C.1
Barak, A.J.2
Boyett, J.D.3
-
46
-
-
35748945147
-
An error model for protein quantification
-
Kreutz, C., Bartolome Rodriguez, M., Maiwald, T., Seidl, M., Blum, H., Mohr, L., and Timmer, J. (2007). An error model for protein quantification. Bioinformatics 23, 2747-2753.
-
(2007)
Bioinformatics
, vol.23
, pp. 2747-2753
-
-
Kreutz, C.1
Bartolome Rodriguez, M.2
Maiwald, T.3
Seidl, M.4
Blum, H.5
Mohr, L.6
Timmer, J.7
-
47
-
-
0038638885
-
Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells
-
Kwik-Uribe, C., Reaney, S., Zhu, Z., and Smith, D. (2003). Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells. Brain Res. 973, 1-15.
-
(2003)
Brain Res
, vol.973
, pp. 1-15
-
-
Kwik-Uribe, C.1
Reaney, S.2
Zhu, Z.3
Smith, D.4
-
48
-
-
33744907279
-
Temporal responses in the disruption of iron regulation by manganese
-
Kwik-Uribe, C., and Smith, D. (2006). Temporal responses in the disruption of iron regulation by manganese. J. Neurosci. Res. 83, 1601-1610.
-
(2006)
J. Neurosci. Res.
, vol.83
, pp. 1601-1610
-
-
Kwik-Uribe, C.1
Smith, D.2
-
49
-
-
0032104739
-
The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms
-
Lee, P., Gelbart, T., West, C., Halloran, C., and Beutler, E. (1998). The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol. Dis. 24, 199-215.
-
(1998)
Blood Cells Mol. Dis.
, vol.24
, pp. 199-215
-
-
Lee, P.1
Gelbart, T.2
West, C.3
Halloran, C.4
Beutler, E.5
-
50
-
-
18944369545
-
Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro
-
Li, G., Zhao, Q., and Zheng, W. (2005). Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicol. Appl. Pharmacol. 205, 188-200.
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.205
, pp. 188-200
-
-
Li, G.1
Zhao, Q.2
Zheng, W.3
-
51
-
-
33748798494
-
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
-
Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., and Cousins, R. J. (2006). Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc. Natl. Acad. Sci. U.S.A. 103, 13612-13617.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 13612-13617
-
-
Liuzzi, J.P.1
Aydemir, F.2
Nam, H.3
Knutson, M.D.4
Cousins, R.J.5
-
52
-
-
13844269120
-
Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders
-
Lu, L., Zhang, L., Li, G., Guo, W., Liang, W., and Zheng, W. (2005). Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders. Neurotoxicology 26, 257-265.
-
(2005)
Neurotoxicology
, vol.26
, pp. 257-265
-
-
Lu, L.1
Zhang, L.2
Li, G.3
Guo, W.4
Liang, W.5
Zheng, W.6
-
53
-
-
34548406422
-
Huntingtin-deficient zebrafish exhibit defects in iron utilization and development
-
Lumsden, A., Henshall, T., Dayan, S., Lardelli, M., and Richards, R. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Hum. Mol. Genet. 16, 1905-1920.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 1905-1920
-
-
Lumsden, A.1
Henshall, T.2
Dayan, S.3
Lardelli, M.4
Richards, R.5
-
54
-
-
0032746341
-
Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
-
Malecki, E. A., Cook, B. M., Devenyi, A. G., Beard, J. L., and Connor, J. R. (1999). Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain. J. Neurol. Sci. 170, 112-118.
-
(1999)
J. Neurol. Sci.
, vol.170
, pp. 112-118
-
-
Malecki, E.A.1
Cook, B.M.2
Devenyi, A.G.3
Beard, J.L.4
Connor, J.R.5
-
55
-
-
70349249314
-
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity
-
Milatovic, D., Zaja-Milatovic, S., Gupta, R. C., Yu, Y., and Aschner, M. (2009). Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol. Appl. Pharmacol. 240, 219-225.
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.240
, pp. 219-225
-
-
Milatovic, D.1
Zaja-Milatovic, S.2
Gupta, R.C.3
Yu, Y.4
Aschner, M.5
-
56
-
-
34248683911
-
Metals ions and neurodegeneration
-
Molina-Holgado, F., Hider, R., Gaeta, A., Williams, R., and Francis, P. (2007). Metals ions and neurodegeneration. Biometals 20, 639-654.
-
(2007)
Biometals
, vol.20
, pp. 639-654
-
-
Molina-Holgado, F.1
Hider, R.2
Gaeta, A.3
Williams, R.4
Francis, P.5
-
57
-
-
52049085768
-
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments
-
Roze, E., Saudou, F., and Caboche, J. (2008). Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments. Curr. Opin. Neurol. 21, 497-503.
-
(2008)
Curr. Opin. Neurol.
, vol.21
, pp. 497-503
-
-
Roze, E.1
Saudou, F.2
Caboche, J.3
-
58
-
-
29144460321
-
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
-
Shin, J., Fang, Z., Yu, Z., Wang, C., Li, S., and Li, X. (2005). Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J. Cell Biol. 171, 1001-1012.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 1001-1012
-
-
Shin, J.1
Fang, Z.2
Yu, Z.3
Wang, C.4
Li, S.5
Li, X.6
-
59
-
-
34447520021
-
Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease
-
Simmons, D., Casale, M., Alcon, B., Pham, N., Narayan, N., and Lynch, G. (2007). Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease. Glia 55, 1074-1084.
-
(2007)
Glia
, vol.55
, pp. 1074-1084
-
-
Simmons, D.1
Casale, M.2
Alcon, B.3
Pham, N.4
Narayan, N.5
Lynch, G.6
-
60
-
-
18144386929
-
Tryptophan metabolism and oxidative stress in patients with Huntington's disease
-
Stoy, N., Mackay, G., Forrest, C., Christofides, J., Egerton, M., Stone, T., and Darlington, L. (2005). Tryptophan metabolism and oxidative stress in patients with Huntington's disease. J. Neurochem. 93, 611-623.
-
(2005)
J. Neurochem.
, vol.93
, pp. 611-623
-
-
Stoy, N.1
Mackay, G.2
Forrest, C.3
Christofides, J.4
Egerton, M.5
Stone, T.6
Darlington, L.7
-
61
-
-
35548937443
-
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
-
Strand, A. D., Baquet, Z. C., Aragaki, A. K., Holmans, P., Yang, L., Cleren, C., Beal, M. F., Jones, L., Kooperberg, C., Olson, J. M., et al. (2007). Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J. Neurosci. 27, 11758-11768.
-
(2007)
J. Neurosci.
, vol.27
, pp. 11758-11768
-
-
Strand, A.D.1
Baquet, Z.C.2
Aragaki, A.K.3
Holmans, P.4
Yang, L.5
Cleren, C.6
Beal, M.F.7
Jones, L.8
Kooperberg, C.9
Olson, J.M.10
-
62
-
-
0024239650
-
Levels and sub-cellular distribution of physiologically important metal ions in neuronal cells cultured from chick embryo cerebral cortex
-
Tholey, G., Ledig, M., Kopp, P., Sargentini-Maier, L., Leroy, M., Grippo, A. A., and Wedler, F. C. (1988a). Levels and sub-cellular distribution of physiologically important metal ions in neuronal cells cultured from chick embryo cerebral cortex. Neurochem. Res. 13, 1163-1167.
-
(1988)
Neurochem. Res.
, vol.13
, pp. 1163-1167
-
-
Tholey, G.1
Ledig, M.2
Kopp, P.3
Sargentini-Maier, L.4
Leroy, M.5
Grippo, A.A.6
Wedler, F.C.7
-
63
-
-
0023839282
-
Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex
-
Tholey, G., Ledig, M., Mandel, P., Sargentini, L., Frivold, A. H., Leroy, M., Grippo, A. A., and Wedler, F. C. (1988b). Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex. Neurochem. Res. 13, 45-50.
-
(1988)
Neurochem. Res.
, vol.13
, pp. 45-50
-
-
Tholey, G.1
Ledig, M.2
Mandel, P.3
Sargentini, L.4
Frivold, A.H.5
Leroy, M.6
Grippo, A.A.7
Wedler, F.C.8
-
64
-
-
0034703869
-
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
-
Trettel, F., Rigamonti, D., Hilditch-Maguire, P., Wheeler, V., Sharp, A., Persichetti, F., Cattaneo, E., and MacDonald, M. (2000). Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum. Mol. Genet. 9, 2799-2809.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2799-2809
-
-
Trettel, F.1
Rigamonti, D.2
Hilditch-Maguire, P.3
Wheeler, V.4
Sharp, A.5
Persichetti, F.6
Cattaneo, E.7
MacDonald, M.8
-
65
-
-
33846225133
-
Huntington's disease
-
Walker, F. (2007). Huntington's disease. Lancet 369, 218-228.
-
(2007)
Lancet
, vol.369
, pp. 218-228
-
-
Walker, F.1
-
66
-
-
45049088251
-
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
-
Wang, X., Miller, D., and Zheng, W. (2008). Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol. Appl. Pharmacol. 230, 167-174.
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.230
, pp. 167-174
-
-
Wang, X.1
Miller, D.2
Zheng, W.3
-
67
-
-
0028178807
-
Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: potential regulation of glutamine synthetase
-
Wedler, F., Vichnin, M., Ley, B., Tholey, G., Ledig, M., and Copin, J. (1994). Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: potential regulation of glutamine synthetase. Neurochem. Res. 19, 145-151.
-
(1994)
Neurochem. Res.
, vol.19
, pp. 145-151
-
-
Wedler, F.1
Vichnin, M.2
Ley, B.3
Tholey, G.4
Ledig, M.5
Copin, J.6
-
68
-
-
71649110532
-
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure
-
Williams, B. B., Li, D., Wegrzynowicz, M., Vadodaria, B. K., Anderson, J. G., Kwakye, G. F., Aschner, M., Erikson, K. M., and Bowman, A. B. (2010). Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J. Neurochem. 112, 227-237.
-
(2010)
J. Neurochem.
, vol.112
, pp. 227-237
-
-
Williams, B.B.1
Li, D.2
Wegrzynowicz, M.3
Vadodaria, B.K.4
Anderson, J.G.5
Kwakye, G.F.6
Aschner, M.7
Erikson, K.M.8
Bowman, A.B.9
-
69
-
-
37149003421
-
Metals and neurotoxicology
-
Wright, R. O., and Baccarelli, A. (2007). Metals and neurotoxicology. J. Nutr. 137, 2809-2813.
-
(2007)
J. Nutr.
, vol.137
, pp. 2809-2813
-
-
Wright, R.O.1
Baccarelli, A.2
-
70
-
-
75949088067
-
Ferroportin is amanganese-responsive protein that decreasesmanganese cytotoxicity and accumulation
-
Yin, Z., Jiang, H., Lee, E.-S. Y., Ni, M., Erikson, K. M., Milatovic, D., Bowman,A.B., andAschner,M. (2010). Ferroportin is amanganese-responsive protein that decreasesmanganese cytotoxicity and accumulation. J. Neurochem. 112, 1190-1198.
-
(2010)
J. Neurochem.
, vol.112
, pp. 1190-1198
-
-
Yin, Z.1
Jiang, H.2
Lee, E.-S.3
Ni, M.4
Erikson, K.M.5
Milatovic, D.6
Bowman, A.B.7
Aschner, M.8
-
71
-
-
0035154912
-
Mutant huntingtin enhances excitotoxic cell death
-
Zeron, M., Chen, N., Moshaver, A., Lee, A., Wellington, C., Hayden, M., and Raymond, L. (2001). Mutant huntingtin enhances excitotoxic cell death. Mol. Cell Neurosci. 17, 41-53.
-
(2001)
Mol. Cell Neurosci.
, vol.17
, pp. 41-53
-
-
Zeron, M.1
Chen, N.2
Moshaver, A.3
Lee, A.4
Wellington, C.5
Hayden, M.6
Raymond, L.7
-
72
-
-
45049085513
-
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
-
Zhang, H., Li, Q., Graham, R., Slow, E., Hayden, M., and Bezprozvanny, I. (2008). Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol. Dis. 31, 80-88.
-
(2008)
Neurobiol. Dis.
, vol.31
, pp. 80-88
-
-
Zhang, H.1
Li, Q.2
Graham, R.3
Slow, E.4
Hayden, M.5
Bezprozvanny, I.6
-
73
-
-
0035815544
-
Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells
-
Zheng, W., and Zhao, Q. (2001). Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells. Brain Res. 897, 175-179.
-
(2001)
Brain Res
, vol.897
, pp. 175-179
-
-
Zheng, W.1
Zhao, Q.2
-
74
-
-
0033606416
-
Alteration of iron homeostasis following chronic exposure to manganese in rats
-
Zheng, W., Zhao, Q., Slavkovich, V., Aschner, M., and Graziano, J. (1999). Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res. 833, 125-132.
-
(1999)
Brain Res
, vol.833
, pp. 125-132
-
-
Zheng, W.1
Zhao, Q.2
Slavkovich, V.3
Aschner, M.4
Graziano, J.5
-
75
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
-
Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B., Goffredo, D., Conti, L., MacDonald, M., Friedlander, R., Silani, V., Hayden, M., et al. (2001). Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293, 493-498.
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
Ciammola, A.2
Rigamonti, D.3
Leavitt, B.4
Goffredo, D.5
Conti, L.6
MacDonald, M.7
Friedlander, R.8
Silani, V.9
Hayden, M.10
-
76
-
-
20444456571
-
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
-
Zuccato, C., Liber, D., Ramos, C., Tarditi, A., Rigamonti, D., Tartari, M., Valenza, M., and Cattaneo, E. (2005). Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol. Res. 52, 133-139.
-
(2005)
Pharmacol. Res.
, vol.52
, pp. 133-139
-
-
Zuccato, C.1
Liber, D.2
Ramos, C.3
Tarditi, A.4
Rigamonti, D.5
Tartari, M.6
Valenza, M.7
Cattaneo, E.8
|