Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: Relevance to role of metals in pathogenesis of prion disease

Toxicological Sciences

Volumn 115, Issue 2, 2010, Pages 535-546

  Choi, Christopher J ^a,b   Anantharam, Vellareddy ^a   Martin, Dustin P ^a   Nicholson, Eric M ^c   Richt, Jürgen A ^a,d   Kanthasamy, Arthi ^a   Kanthasamy, Anumantha G ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b ALCON RESEARCH LTD   (United States)

^c NATIONAL ANIMAL DISEASE CENTER   (United States)

^d KANSAS STATE UNIVERSITY   (United States)

Author keywords

Environmental factors; Manganese; Metals; Neurotoxicity; Prion accumulation; Scrapie

Indexed keywords

MANGANESE; MESSENGER RNA; PRION PROTEIN; PROTEINASE K; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOPLASM; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LYSOSOME; METAL BINDING; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRION DISEASE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SCRAPIE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; CELL FRACTIONATION; CELL MEMBRANE; CELLS, CULTURED; CHLORIDES; CYTOSOL; ENDOPEPTIDASE K; MANGANESE COMPOUNDS; MICE; MURAMIDASE; NEURONS; PRION DISEASES; PRPC PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UP-REGULATION;

SCRAPIE PRION;

EID: 77954079854     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq049     Document Type: Article

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