Breaking self-tolerance toward cytochrome P4502E1 (CYP2E1) in chronic hepatitis C: Possible role for molecular mimicry

Journal of Hepatology

Volumn 53, Issue 3, 2010, Pages 431-438

  Sutti, Salvatore ^a   Vidali, Matteo ^a   Mombello, Cristina ^a   Sartori, Massimo ^c   Ingelman Sundberg, Magnus ^b   Albano, Emanuele ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

Author keywords

Autoimmunity; Cytochrome P450; HCV infection; Liver fibrosis

Indexed keywords

AUTOANTIBODY; CYTOCHROME P450 2E1; EPITOPE; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN G1; LYSINE; NONSTRUCTURAL PROTEIN 5B;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CONFORMATION; CONJUGATION; CROSS REACTION; DISEASE SEVERITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOPRECIPITATION; INFLAMMATION; LIVER INJURY; MALE; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIMULATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; BASE SEQUENCE; CROSS REACTIONS; CYTOCHROME P-450 CYP2E1; DNA PRIMERS; EPITOPES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SELF TOLERANCE; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77955848076     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.03.030     Document Type: Article

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