Use of molecular simulation for mapping conformational CYP2E1 epitopes

Journal of Biological Chemistry

Volumn 279, Issue 49, 2004, Pages 50949-50955

  Vidali, Matteo ^a   Hidestrand, Mats ^b   Eliasson, Erik ^c   Mottaran, Elisa ^a   Reale, Emanuela ^a   Rolla, Roberta ^a   Occhino, Giuseppa ^a   Albano, Emanuele ^a   Ingelman Sundberg, Magnus ^b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; COMPUTER SIMULATION; CRYSTAL STRUCTURE; DISEASES; DRUG PRODUCTS; ESCHERICHIA COLI; MUTAGENESIS; TOXICITY;

CYTOCHROME P450; EPITOPES; HALOTHANE HAPATITIS; LIVER;

ANTIBODIES;

AMINO ACID; CYTOCHROME P450; CYTOCHROME P450 2C5; CYTOCHROME P450 2E1; ENZYME VARIANT; EPITOPE; UNCLASSIFIED DRUG;

ALCOHOL LIVER DISEASE; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTIGEN DETECTION; ARTICLE; BETA SHEET; CLINICAL ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; EPITOPE MAPPING; ESCHERICHIA COLI; HALOTHANE LIVER INJURY; HEPATITIS; HUMAN; IMMUNOPRECIPITATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN MOTIF;

ANESTHETICS, INHALATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA PRIMERS; DNA, COMPLEMENTARY; EPITOPE MAPPING; EPITOPES; ESCHERICHIA COLI; HALOTHANE; HEPATITIS; HUMANS; IMMUNOPRECIPITATION; LIVER DISEASES, ALCOHOLIC; LYSINE; MODELS, MOLECULAR; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEROID 21-HYDROXYLASE;

ESCHERICHIA COLI;

EID: 10944223470     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407329200     Document Type: Article

References (34)

1. Ronis, M. J. J., Lindros, K. O., and Ingelman-Sundberg, M. (1996) in Cytochromes P450: Metabolic and Toxicological Aspects (Ioannides, C., ed) pp. 211-239, CRC Press, Boca Raton
2. Bourdi, M., Chen, W., Peter, R. M., Martin, J. L., Buters, J. T. M., Nelson, S. D., and Pohl, L. R. (1996) Chem. Res. Toxicol. 9, 1159-1166
3. Eliasson, E., and Kenna, J. G. (1996) Mol. Pharmacol. 50, 573-582
4. Njoku, D. B., Greenberg, R. S., Bourdi, M., Borkowf, C. B., Dake, E. M., Martin, J. L., and Pohl, L. R. (2002) Anesth. Analg. 94, 243-249
5. Lytton, S. D., Hellander, A., Zhang-Gouillon, Z. Q., Stokkeland, K., Bordone, R., Aricò, S., Albano, E., French, S. W., and Ingelman-Sundberg., M. (1999) Mol. Pharmacol. 55, 223-233
6. Vidali, M., Stewart, S. F., Rolla, R., Daly, A. K., Chen, Y., Mottaran, E., Jones, D. E., Leathart, J. B., Day, C. P., and Albano, E. (2003) Hepatology 37, 277-285
7. Stewart, S. F., Jones, D. E., Vidali, M., Haugk, B., Burt, A. D., Albano, E., and Day, C. P. (2004) J. Hepatol. 40, Suppl. 1, 176
8. Bourdi, M., Larrey, D., Nataf, J., Bernuau, J., Pessayre, D., Iwasaki, M., Guengerich, F. P., and Beaune, P. H. (1990) J. Clin. Investis. 85, 1967-1973
9. Beaune, P. H., Dansette, P. M., Mansuy, D., Kiffel, L., Finck, M., Amar, C., Leroux, J. P., and Homberg, J. C. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 551-555
10. Leeder, J., Riley, S. R. J., Cook, V. A., and Spielberg, S. P. (1992) J. Pharmacol. Exp. Ther. 263, 360-367
11. Lytton, S. D., Berg, U., Nemeth, A., and Ingelman-Sundberg, M. (2002) Clin. Exp. Immmunol. 127, 293-302
12. Manns, M. P., and Obermayer-Straub, P. (1997) Hepatology 26, 1054-1066
13. Winqvist, O., Gustafsson, J., Rorsman, F., Karlsson, F. A., and Kämpe, O. (1993) J. Clin. Investig. 92, 2377-2385
14. Uibo, R., Aavik, E., Peterson, P., Perheentupa, J., Aranko, S., Pelkonen, R., and Krohn, K. J. (1994) J. Clin. Endocrinol. Metab. 78, 323-328
15. Lecoeur, S., Andre, C., and Beaune, P. H. (1996) Mol. Pharmacol. 50, 326-333
16. Leeder, J. S., Gaedigk, A., Lu, X., and Cook, V. A. (1996) Mol. Pharmacol. 49, 234-243
17. Belloc, C., Gauffre, A., André, C., and Beaune, P. H. (1997) Pharmacogenetics 7, 181-186
18. Manns, M. P., Griffin, K. J., Sullivan, K. F., and Johnson, E. F. (1991) J. Clin. Investig. 88, 1370-1378
19. Yamamoto, A. M., Cresteil, D., Homberg, J. C., and Alvarez, F. (1993) Gastroenterology 104, 1762-1767
20. Ma, Y., Thomas, M. G., Okamoto, M., Bogdamos, D. P., Nagl, S., Kerkar, N., Lopes, A. R., Muratori, L., Bianchi, F. B., Mieli-Vergani, G., and Vergani, D. (2002) J. Immunol. 169, 277-285
21. Kerkar, N., Choudhuri, K., Ma, Y., Mahmoud, A., Bogdamos, D. P., Muratori, L., Bianchi, F. B., Williams, R., Mieli-Vergani, G., and Vergani, D. (2003) J. Immunol. 170, 1481-1489
22. Kenna, J. G., Neuberger, J., and Williams, R. (1998) Hepatology 8, 1635-1641
23. Smith, G. C. M., Kenna, J. G., Harrison, D. J., Tew, D., and Wolf, C. R. (1993) Lancet 342, 963-964
24. Schwede, T., Koop, J., Guex, N., and Peitsch, M. C. Nucleic Acids Res. 31, 3381-3385
25. Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., and McRee, D. E. (2000) Mol. Cell 5, 121-131
26. Barnes, H. J. (1996) Methods Enzymol. 272, 3-14
27. Gillam, E. M., Guo, Z., and Guengerich, F. P. (1994) Arch. Biochem. Biophys. 312, 59-66
28. Omura, T., and Sato, R. (1964) J. Biol. Chem. 239, 2370-2378
29. Lewis, D. F. V., Lake, B. G., Bird, M. G., Loizou, G. D., Dickins, M., and Goldfarb, P. S. (2003) Toxicol. In Vitro 17, 93-105
30. Jameson, B. A., and Wolf, H. (1988) Comput. Appl. Biosci. 4, 181-186
31. Duclos-Vallée, J. C., Hajoui, O., Yamamoto, A. M., Jacqz-Aigrain, E., and Alvarez, F. (1995) Gastroenterology 108, 470-476
32. Neve, E. P. A., Hidestrand, M., and Ingelman-Sundberg, M. (2003) Biochemistry 42, 14566-14575
33. Wu, D. F., and Cederbaum, A. I. (1992) Hepatology 15, 515-524
34. Clot, P., Parola, M., Bellomo, G., Dianzani, U., Carini, R., Tabone, M., Aricò, S., Ingelman-Sundberg, M., and Albano, E. (1997) Gastroenterology 113, 265-276