Cytochrome P450 2A6: A new hepatic autoantigen in patients with chronic hepatitis C virus infection

Journal of Hepatology

Volumn 39, Issue 5, 2003, Pages 800-806

  Dalekos, Georgios N ^a,b   Obermayer Straub, Petra ^a   Bartels, Moritz ^a   Maeda, Takashi ^a   Kayser, Anne ^a   Braun, Sabine ^a   Loges, Stephanie ^a   Schmidt, Eleonore ^a   Gershwin, M Eric ^c   Manns, Michael P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF THESSALY   (Greece)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune hepatitis; Autoimmunity; Chronic hepatitis; Cytochrome P450 1A2; Cytochrome P450 2A6; Cytochrome P450 2D6; Hepatitis C virus; LKM antibody

Indexed keywords

AUTOANTIGEN; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; METHIONINE; SULFUR 35;

ADOLESCENT; ADULT; AGED; ANTIBODY TITER; ANTIGEN DETECTION; AUTOIMMUNE DISEASE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; CHRONIC HEPATITIS; CONFERENCE PAPER; FEMALE; FLAVIVIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADIOASSAY; RHEUMATIC DISEASE; SCHOOL CHILD; SEROPREVALENCE;

EID: 10744221597     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00356-8     Document Type: Conference Paper

References (39)

1. Manns MP, Obermayer-Straub P. Cytochromes P450 and UDP- glucuronosyltransferases: Model autoantigens to study drug-induced, virus-induced and autoimmune liver disease. Hepatology 1997;26:1054-1066.
2. Cerny A, Chisari FV. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 1999;30:595-601.
3. Manns MP, Obermayer-Straub P. Viral induction of autoimmunity: mechanisms and examples in hepatology. J Viral Hepatol 1997;4:42-47.
4. Dalekos GN, Manoussakis MN, Zervou E, Tsianos EV, Moutsopoulos HM. Immunologic and viral markers in anti-HIV negative heroin addicts. Eur J Clin Invest 1993;23:219-225.
5. Clifford BD, Donahue D, Smith S, Cable E, Luttig B, Manns MP, Bonkovsky HL. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C. Hepatology 1995;231:613-619.
6. Dalekos GN, Kistis K, Boumba D, Voulgari P, Zervou E, Drosos AA, Tsianos EV. Increased incidence of anticardiolipin antibodies in patients with hepatitis C is not associated with aetiopathogenetic link to antiphospholipid syndrome. Eur J Gastroenterol Hepatol 2000;12:67-74.
7. Bortolotti F, Vajro P, Balli F, Giacchino R, Crivellaro C, Barbera C, et al. Non-organ specific autoantibodies in children with chronic hepatitis C. J Hepatol 1996;25:614-620.
8. Dalekos GN, Makri E, Loges S, Obermayer-Straub P, Zachou K, Tsikrikas T, et al. Increased incidence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece. Eur J Gastroenterol Hepatol 2002;14:35-42.
9. Seelig R, Renz M, Bünger G, Schröter H, Seelig HP. Anti-LKM-1 antibodies determined by use of recombinant P4502D6 in ELISA and Western Blot and their association with anti-HCV and HCV-RNA. Clin Exp Immunol 1993;92:373-380.
10. Manns MP, Griffin KJ, Sullivan KF, Johnson EF. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest 1991;88:1370-1378.
11. Lenzi M, Johnson PJ, McFarlane IG, Ballardini G, Smith HM, McFarlane BM, et al. Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity. Lancet 1991;338:277-280.
12. Homberg JC, Abuaf N, Bernard O, Islam S, Alvarez F, Khalil SH, et al. Chronic active hepatitis associated with antiliver/kidney microsome type 1: a second type of 'autoimmune' hepatitis. Hepatology 1987;7:1333-1339.
13. Zanger UM, Hauri HP, Loeper J, Homberg JC, Meyer UA. Antibodies against human cytochrome P-450dbl in autoimmune hepatitis type 2. Proc Natl Acad Sci USA 1988;85:8256-8260.
14. Guenguen M, Yamamotoh AM, Bernard O, Alvarez F. Anti-liver kidney microsome antibody type 1 recognizes human cytochrome P450 dbl. Biochem Biophys Res Commun 1989;159:542-547.
15. Manns MP, Johnson EF, Griffin KJ, Tan EM, Sullivan KF. Major antigen of liver kidney microsomal antibodies in idiopathic autoimmune hepatitis is cytochrome P450dbl. J Clin Invest 1989;83:1066-1072.
16. Yamamoto AM, Johanet C, Duclos-Vallee JC, Bustarret FA, Alvarez F, Homberg JC, et al. new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay. Clin Exp Immunol 1997;108:396-400.
17. Ma Y, Gregorio G, Gäken J, Muratori L, Bianchi FB, Mieli-Vergani G, et al. Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P450 2D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection. J Hepatol 1997;26:1396-1402.
18. Nishioka M, Morshed SA, Kono K, Himoto T, Parveen S, Arima K, et al. Frequency and significance of antibodies to P450IID6 protein in Japanese patients with chronic hepatitis C. J Hepatol 1997;26:992-1000.
19. Durazzo M, Philipp T, Van Pelt FNAM, Lüttig B, Borghesio E, Michel G, et al. Heterogeneity of microsomal autoantibodies (LKM) in chronic hepatitis C and D virus infection. Gastroenterology 1995;108:455-462.
20. Miyakawa H, Kitazawa E, Kikuchi K, Fujikawa H, Kawaguchi N, Abe K, et al. Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C. Autoimmunity 2001;33:23-32.
21. Kammer AR, van der Berg SH, Grabscheid B, Hunziker IP, Kwappenberg KMC, Reichen J, et al. Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition. J Exp Med 1999;190:169-176.
22. Manns MP, Hepatitis C, and autoimmune hepatitis. Hepatology (Letter) 2000;31:811.
23. Clemente MG, Obermayer-Straub P, Meloni A, Strassburg CP, Arangino V, Tukey RH, et al. Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metabol 1997;82:1353-1361.
24. Clemente MG, Meloni A, Obermayer-Straub P, Frau F, Manns MP, DeVirgiliis S. Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1. Gastroenterology 1998;114:324-328.
25. Gebre-Medhin G, Husebye ES, Gustafsson J, Winqvist O, Goksoyr A, Rorsman F, et al. Cytochrome P450IA2 and aromatic L-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I. FEBS Lett 1997;412:439-445.
26. Obermayer-Straub P, Perheentupa J, Braun S, Kayser A, Barut A, Loges S, et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy. Gastroenterology 2001;121:668-677.
27. Aaltonen J, Bjoerses P, Perheentupa J, Horelli-Kuitunen N, Paloti A, Peltonen L, et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc finger domains. Nat Genet 1997;17:399-403.
28. Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, et al. Positional cloning of the APECED gene. Nat Genet 1997;17:393-398.
29. Ahonen P, Myllärniemi S, Sipilä I, Perheentupa J. Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 1990;322:1829-1836.
30. Strassburg C, Obermayer-Straub P, Alex B, Durazzo M, Rizzetto M, Tukey RH, et al. Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology 1996;11:1582-1592.
31. Michitaka K, Durazzo M, Tillmann HL, Walker D, Philipp T, Manns MP. Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2. Gastroenterology 1994;106:1603-1610.
32. Tillmann HL, Heringlake S, Trautwein C, Meissner D, Nashan B, Schlitt H-J, et al. Antibodies against GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection. Hepatology 1998;28:379-384.
33. Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-938.
34. Strassburg C, Alex B, Zindy F, Gerken G, Lüttig B, Meyer zum Büschenfelde KH, et al. Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic diseases. J Hepatol 1996;25:859-866.
35. Manns M, Gerken G, Kyriatsoulis A, Staritz M, Meyer zum Büschenfelde KH. Characterization of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen. Lancet 1987;I:292-294.
36. Manns M, Gerken G, Kyriatsoulis A, Trautwein C, Reske K, Meyer zum Büschenfelde K-H. Two different subtypes of antimitochondrial antibodies are associated with primary biliary cirrhosis: identification and characterization by radioimmunoassay and immunoblotting. Hepatology 1987;5:893-899.
37. Yamano S, Tatsuno J, Gonzalez FJ. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 1990;29:1322-1329.
38. Dalekos GN, Wedemeyer H, Obermayer-Straub P, Kayser A, Barut A, Frank H, et al. Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during a-interferon treatment. J Hepatol 1999;30:366-375.
39. Ma Y, Thomas MG, Okamoto M, Bogdanos DP, Nagl S, Kerkar N, et al. Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule. J Immunol 2002;169:277-285.