Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing

FASEB Journal

Volumn 24, Issue 8, 2010, Pages 2612-2619

  Besaratinia, Ahmad ^a   Pfeifer, Gerd P ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Cancer; Etiology; Mutation; Tumor suppressor gene

Indexed keywords

3 NITROBENZANTHRONE; AFLATOXIN B1; ARISTOLOCHIC ACID; BENZO[A]PYRENE; DNA POLYMERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PROTEIN P53; PYRIMIDINE NUCLEOTIDE; TOBACCO SMOKE;

AIR POLLUTANT; ALLELE; BASE PAIRING; CARCINOGEN TESTING; CARCINOGENESIS; CODING; CPG ISLAND; DNA BINDING; DNA REPAIR; DNA SEQUENCE; EXON; FIBROBLAST; FOOD CONTAMINATION; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; HEPATITIS B VIRUS; HUMAN; HUMAN GENOME; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL DAMAGE; MOUSE; MOUSE STRAIN; MUTAGENESIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; SUNLIGHT; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET B RADIATION; ULTRAVIOLET C RADIATION; ULTRAVIOLET RADIATION; WILD TYPE;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; ENVIRONMENT; GENE KNOCK-IN TECHNIQUES; GENES, P53; HUMANS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTAGENESIS; NEOPLASMS;

ANIMALIA; MURINAE; NICOTIANA TABACUM;

EID: 77955811838     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-157263     Document Type: Review

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