Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 2963-2968

  Liu, Zhipei ^a   Hergenhahn, Manfred ^a   Schmeiser, Heinz H ^a   Wogan, Gerald N ^b   Hong, Amanda ^a   Hollstein, Monica ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Carcinogen; Gene targeting; Mutation spectrum; Tumor suppressor

Indexed keywords

ARISTOLOCHIC ACID; DNA BINDING PROTEIN; PROTEIN P53;

AMINO ACID SUBSTITUTION; ARTICLE; DNA SEQUENCE; EMBRYO DEVELOPMENT; EXON; FIBROBLAST; GENE MUTATION; GENE TARGETING; GENETIC SELECTION; HUMAN; HUMAN CELL; MUTAGENESIS; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN DOMAIN; RESTRICTION MAPPING; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ANIMALS; BINDING SITES; DNA; EMBRYO; FIBROBLASTS; GENES, P53; HUMANS; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MUTATION; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 1542327685     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308607101     Document Type: Article

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