Probing the role of the cation-π interaction in the binding sites of GPCRs using unnatural amino acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 29, 2009, Pages 11919-11924

  Torrice, Michael M ^a   Bower, Kiowa S ^a   Lester, Henry A ^b   Dougherty, Dennis A ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

D2 receptor; Fluorination; Membrane protein

Indexed keywords

AMINO ACID DERIVATIVE; AROMATIC AMINO ACID; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; MUSCARINIC M2 RECEPTOR; TRYPTOPHAN DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; FLUORINATION; GENE EXPRESSION; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR PROBE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; XENOPUS LAEVIS;

AMINO ACIDS; ANIMALS; BINDING SITES; CATIONS; CODON, NONSENSE; FLUORINE; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, MUSCARINIC M2; RECEPTORS, DOPAMINE D2; RECEPTORS, G-PROTEIN-COUPLED; STATIC ELECTRICITY; XENOPUS;

EID: 67749122587     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903260106     Document Type: Article

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