Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes

Biochemical Pharmacology

Volumn 74, Issue 8, 2007, Pages 1164-1171

  Taylor, Palmer ^a   Talley, Todd T ^a   Radic', Zoran ^a   Hansen, Scott B ^a   Hibbs, Ryan E ^a   Shi, Jian ^a  

^a San Diego   (United States)

Author keywords

Acetylcholine binding protein; Allosteric modulators; Channel vestibule; Competitive ligand site; Crystal structure; Fluorescence anisotropy; Freeze frame click chemistry; Isotope exchange; Nicotinic receptor structure

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINE BINDING PROTEIN; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME SPECIFICITY; FLUORESCENCE SPECTROSCOPY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; SPECTROMETRY;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CRYSTALLIZATION; DRUG DESIGN; HUMANS; MOLECULAR SEQUENCE DATA; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RECEPTORS, NICOTINIC; SPECTROMETRY, FLUORESCENCE;

EID: 34548672882     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.07.038     Document Type: Article

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