Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout

Journal of Autoimmunity

Volumn 25, Issue 3, 2005, Pages 193-198

  Nakayama, M ^a   Babaya, N ^a   Miao, D ^a   Sikora, K ^a   Elliott, J F ^b   Eisenbarth, G S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Insulin; Insulin B:9 23; NOD; Thymus; Transgene

Indexed keywords

ALANINE; AMINO ACID; AUTOANTIBODY; EPITOPE; INSULIN; MESSENGER RNA; PREPROINSULIN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GENE MUTATION; IMMUNOMODULATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; THYMUS; TRANSGENE;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; AUTOANTIBODIES; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; INSULIN; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, TRANSGENIC; PROINSULIN; PROTEIN ISOFORMS; PROTEIN PRECURSORS; RNA, MESSENGER; THYMUS GLAND;

EID: 27844611983     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.09.014     Document Type: Article

References (25)

1. D. Mathis, and C. Benoist Back to central tolerance Immunity 20 2004 509 516
2. A. Pugliese, M. Zeller, A. Fernandez, L.J. Zalcberg, R.J. Bartlett, and C. Ricordi The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type I diabetes Nat Genet 15 1997 293 297
3. K.M. Smith, D.C. Olson, R. Hirose, and D. Hanahan Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance Int Immunol 9 1997 1355 1365
4. A.A. Chentoufi, and C. Polychronakos Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes Diabetes 51 2002 1383 1390
5. R.J. Steptoe, J.M. Ritchie, and L.C. Harrison Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes J Clin Invest 111 2003 1357 1363
6. E. Jaeckel, M.A. Lipes, and H. von Boehmer Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes Nat Immunol 5 2004 1028 1035
7. K. Thebault-Baumont, D. Dubois-LaForgue, P. Krief, J.P. Briand, P. Halbout, and K. Vallon-Geoffroy Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice J Clin Invest 111 2003 851 857
8. B. Faideau, J.P. Briand, C. Lotton, I. Tardivel, P. Halbout, and J. Jami Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice J Immunol 172 2004 25 33
9. H. Moriyama, N. Abiru, J. Paronen, K. Sikora, E. Liu, and D. Miao Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the NOD mouse Proc Natl Acad Sci USA 100 2003 10376 10381
10. P. Halbout, J.P. Briand, C. Becourt, S. Muller, and C. Boitard T cell response to preproinsulin I and II in the non-obese diabetic mouse J Immunol 169 2002 2436 2443
11. S.C. Kent, Y. Chen, L. Bregoli, S.M. Clemmings, N.S. Kenyon, and C. Ricordi Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope Nature 435 2005 224 228
12. W. Chen, I. Bergerot, J.F. Elliott, L.C. Harrison, N. Abiru, and G.S. Eisenbarth Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes J Immunol 167 2001 4926 4935
13. D. Daniel, R.G. Gill, N. Schloot, and D. Wegmann Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice Eur J Immunol 25 1995 1056 1062
14. M. Nakayama, N. Abiru, H. Moriyama, N. Babaya, E. Liu, and D. Miao Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice Nature 435 2005 220 223
15. B. Duvillié, N. Cordonnier, L. Deltour, F. Dandoy-Dron, J.-M. Itier, and E. Monthioux Phenotypic alterations in insulin-deficient mutant mice Proc Natl Acad Sci USA 94 1997 5137 5140
16. M. Nakayama, H. Moriyama, N. Abiru, S.R. Babu, K. Sikora, and M. Li The establishment of native insulin-negative NOD mice and methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene Ann NY Acad Sci 1037 2004 193 198
17. L. Yu, D.T. Robles, N. Abiru, P. Kaur, M. Rewers, and K. Kelemen Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes Proc Natl Acad Sci USA 97 2000 1701 1706
18. M.K. Brimnes, T. Jensen, T.N. Jorgensen, B.K. Michelsen, J. Troelsen, and O. Werdelin Low expression of insulin in the thymus of non-obese diabetic mice J Autoimmun 19 2002 203 213
19. M.B. French, J. Allison, D.S. Cram, H.E. Thomas, M. Dempsey-Collier, and A. Silva Transgenic expression of mouse proinsulin II prevents diabetes in non-obese diabetic mice Diabetes 46 1997 34 39
20. H. Moriyama, L. Wen, N. Abiru, E. Liu, L. Yu, and D. Miao Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide Proc Natl Acad Sci USA 99 2002 5539 5544
21. N. Abiru, D. Wegmann, E. Kawasaki, P. Gottlieb, E. Simone, and G.S. Eisenbarth Dual overlapping peptides recognized by insulin peptide B:9-23 reactive T cell receptor AV13S3 T cell clones of the NOD mouse J Autoimmun 14 2000 231 237
22. D.G. Alleva, A. Gaur, L. Jin, D. Wegmann, P.A. Gottlieb, and A. Pahuja Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide Diabetes 51 2002 2126 2134
23. F.S. Wong, J. Karttunen, C. Dumont, L. Wen, I. Visintin, and I.M. Pilip Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library Nat Med 5 1999 1026 1031
24. J.D. Trudeau, C. Kelly-Smith, C.B. Verchere, J.F. Elliott, J.P. Dutz, and D.T. Finegood Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood J Clin Invest 111 2003 217 223
25. F.S. Wong, A.K. Moustakas, L. Wen, G.K. Papadopoulos, and C.A. Janeway Jr. Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus Proc Natl Acad Sci USA 99 2002 5551 5556