Application and interpretation of transmission/disequilibrium tests: Transmission of HLA-DQ haplotypes to unaffected siblings in 526 families with type 1 diabetes

American Journal of Human Genetics

Volumn 66, Issue 2, 2000, Pages 740-743

  Lie, Benedicte A ^a,c   Rønningen, Kjersti S ^b   Akselsen, Hanne E ^a   Thorsby, Erik ^a   Undlien, Dag E ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ ANTIGEN;

ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; NORWAY; PRIORITY JOURNAL;

EID: 0033912572     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302780     Document Type: Article

References (22)

1. Bennett ST, Lucassen AM, Gough SC, Powell EE, Undlien DE, Pritchard LE, Merriman ME, et al (1995) Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 9:284-292
2. Boehnke M, Langefeld CD (1997) A transmission/disequilibrium test that uses both affected and unaffected offspring. Am J Hum Genet Suppl 61:A269
3. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, et al (1995) Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 9:80-85
4. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, et al (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136
5. Delepine M, Pociot F, Habita C, Hashimoto L, Froguel P, Rotter J, Cambon-Thomsen A, et al (1997) Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. Am J Hum Genet 60:174-187
6. Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, et al (1997) Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. Diabetes 46:695-700
7. Kawasaki E, Noble J, Erlich H, Mulgrew CL, Fain PR, Eisenbarth GS (1998) Transmission of DQ haplotypes to patients with type 1 diabetes. Diabetes 47:1971-1973
8. Lie BA, Todd JA, Pociot F, Nerup J, Akselsen HE, Joner G, Dahl-Jørgensen K, et al (1999) The predisposition to type 1 diabetes linked to the human leukocyte antigen complex (IDDM1) includes at least one non-class II gene. Am J Hum Genet 64:793-800
9. Merriman TR, Eaves I, Twells R, Merriman ME, Danoy PAC, Muxworthy CE, Hunter KMD, et al (1998) Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6). Hum Mol Genet 7:517-524
10. Merriman T, Twells R, Merriman ME, Eaves I, Cox R, Cucca F, McKinney P, et al (1997) Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. Hum Mol Genet 6:1003-1010
11. Nakagawa Y, Kawaguchi Y, Twells RC, Muxworthy C, Hunter KM, Wilson A, Merriman ME, et al (1998) Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. Am J Hum Genet 63:547-556
12. Nistico L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, et al (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes: Belgian Diabetes Registry. Hum Mol Genet 5:1075-1080
13. Reed P, Cucca F, Jenkins S, Merriman M, Wilson A, McKinney P, Bosi E, et al (1997) Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11. Hum Mol Genet 6:1011-1016
14. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
15. Sham PC, Curtis D (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59:323-336
16. She JX (1996) Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunol Today 17:323-329
17. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
18. Thorsby E (1997) HLA associated diseases. Hum Immunol 53: 1-11
19. Todd JA (1991) A protective role of the environment in the development of type 1 diabetes? Diabetes Med 8: 906-910
20. -(1997) Genetics of type 1 diabetes. Pathol Biol 45: 219-227
21. Undlien DE, Akselsen HE, Joner G, Dahl-Jørgensen K, Aagenæs Ø, Søvik O, Thorsby E, et al (1995a) No difference in the parental origin of susceptibility HLA class II haplotypes among Norwegian patients with insulin-dependent diabetes mellitus. Am J Hum Genet 57:1511-1514
22. Undlien DE, Bennett ST, Todd JA, Akselsen HE, Ikaheimo I, Reijonen H, Knip M, et al (1995b) Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene. Diabetes 44:620-625