Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men

Journal of Bone and Mineral Research

Volumn 25, Issue 8, 2010, Pages 1830-1838

  Roshandel, Delnaz ^a   Holliday, Kate L ^a   Pye, Stephen R ^a,l   Boonen, Steven ^b,l   Borghs, Herman ^b,l   Vanderschueren, Dirk ^b,l   Huhtaniemi, Ilpo T ^c,l   Adams, Judith E ^a   Ward, Kate A ^a,d   Bartfai, Gyorgy ^e,l   Casanueva, Felipe ^f,l   Finn, Joseph D ^a,l   Forti, Gianni ^g,l   Giwercman, Aleksander ^h,l   Han, Thang S ⁱ   Kula, Krzysztof ^j,l   Lean, Michael E ⁱ   Pendleton, Neil ^a   Punab, Margus ^k,l   Silman, Alan J ^a,l   Wu, Frederick C ^a,l   Thomson, Wendy ^a   O'Neill, Terence W ^a,l   Petrone, Luisa ^l   Corona, Glovanni ^l   Slowikowska Hilczer, Jolanta ^l   Walczak Jedrzejowska, Renata ^l   Steer, Philip ^l   Tajar, Abdelouahid ^l   Lee, David ^l   Lage, Mary ^l   Fo'ldesi, Imre ^l   Fejes, Imre ^l   Korrovitz, Paul ^l   Jiang, Min ^l   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

^e UNIVERSITY OF SZEGED   (Hungary)

^f HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^g UNIVERSITY OF FLORENCE   (Italy)

^h LUND UNIVERSITY   (Sweden)

ⁱ UNIVERSITY OF GLASGOW   (United Kingdom)

^j MEDICAL UNIVERSITY OF LODZ   (Poland)

^k TARTU UNIVERSITY CLINICS   (Estonia)

^l Tartu University Clinics ^*

more..

Author keywords

Association; Bone densitometry; Bone turnover markers; Osteoporosis; SNPS

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROCOLLAGEN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ADULT; AGED; AGING; ALLELE; ARTICLE; BONE DENSITY; BONE TURNOVER; CALCANEUS; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; GENETIC VARIABILITY; GENOTYPE; HIP; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; BONE AND BONES; BONE DENSITY; BONE REMODELING; EUROPE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OSTEOPROTEGERIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION;

EID: 77955740567     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.78     Document Type: Article

References (44)

1. Melton LJ III, Chrischilles EA, Cooper C, Lane AW, Riggs BL. Perspective: How many women have osteoporosis? J Bone Miner Res. 1992;7:1005-1010.
2. van Staa TP, Dennison EM, Leufkens HG, Cooper C. Epidemiology of fractures in England and Wales. Bone. 2001;29:517-522.
3. Dargent-Molina P, Schott AM, Hans D, et al. Separate and combined value of bone mass and gait speed measurements in screening for hip fracture risk: results from the EPIDOS study. Epidemiologie de l'Osteoporose. Osteoporos Int. 1999;9:188-192.
4. Briot K, Roux C. What is the role of DXA, QUS and bone markers in fracture prediction, treatment allocation and monitoring? Best Pract Res Clin Rheumatol. 2005;19:951-964.
5. Bauer DC, Garnero P, Harrison S, et al. Biochemical markers of bone turnover, hip bone loss and fracture in older men: The MrOS study. J Bone Miner Res. 2009;24:2032-2038.
6. Garnero P, Hausherr E, Chapuy MC, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Miner Res. 1996;11:1531-1538. (Pubitemid 26331009)
7. Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res. 2000;15:1526-1536.
8. Videman T, Levalahti E, Battie MC, Simonen R, Vanninen E, Kaprio J. Heritability of BMD of femoral neck and lumbar spine: a multivariate twin study of Finnish men. J Bone Miner Res. 2007;22:1455-1462.
9. Krall EA, wson-Hughes B. Heritable and life-style determinants of bone mineral density. J Bone Miner Res. 1993;8:1-9. (Pubitemid 23033990)
10. Garnero P, Arden NK, Griffiths G, Delmas PD, Spector TD. Genetic influence on bone turnover in postmenopausal twins. J Clin Endocrinol Metab. 1996;81:140-146.
11. Hadjidakis DJ, Androulakis II. Bone remodeling. Ann N Y Acad Sci. 2006;1092:385-396.
12. Hsu YH, Niu T, Terwedow HA, et al. Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet. 2006;118:568-577.
13. Xiong DH, Shen H, Zhao LJ, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 2006;21:1678-1695.
14. Mencej S, Prezelj J, Kocijancic A, Ostanek B, Marc J. Association of TNFSF11 gene promoter polymorphisms with bone mineral density in postmenopausal women. Maturitas. 2006;55:219-226. (Pubitemid 44397347)
15. Kim JG, Kim JH, Kim JY, et al. Association between osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women. Menopause. 2007;14:913-918.
16. Choi JY, Shin A, Park SK, et al. Genetic polymorphisms of OPG, RANK, and ESR1 and bone mineral density in Korean postmenopausal women. Calcif Tissue Int. 2005;77:152-159.
17. Koh JM, Park BL, Kim DJ, et al. Identification of novel RANK polymorphisms and their putative association with low BMD among postmenopausal women. Osteoporos Int. 2007;18:323-331.
18. Arko B, Prezelj J, Komel R, Kocijancic A, Hudler P, Marc J. Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis.[see comment]. J Clini Endocrinol & Metab. 2002;87:4080-4084.
19. Langdahl BL, Carstens M, Stenkjaer L, Eriksen EF. Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J Bone Miner Res. 2002;17:1245-1255.
20. Ohmori H, Makita Y, Funamizu M, et al. Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis. J Hum Genet. 2002;47:400-406.
21. Wynne F, Drummond F, O'Sullivan K, et al. Investigation of the genetic influence of the OPG, VDR (Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population. Calcif Tissue Int. 2002;71:26-35.
22. Yamada Y, Ando F, Niino N, Shimokata H. Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men. Mol Genet & Metab. 2003;80:344-349. (Pubitemid 37324722)
23. Brandstrom H, Gerdhem P, Stiger F, et al. Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women. Calcif Tissue Int. 2004;74:18-24. (Pubitemid 38166600)
24. Jorgensen HL, Kusk P, Madsen B, Fenger M, Lauritzen JB. Serum osteoprotegerin (OPG) and the A163G polymorphism in the OPG promoter region are related to peripheral measures of bone mass and fracture odds ratios. J Bone & Miner Metab. 2004;22:132-138.
25. Arko B, Prezelj J, Kocijancic A, Komel R, Marc J. Association of the osteoprotegerin gene polymorphisms with bone mineral density in postmenopausal women. Maturitas. 2005;51:270-279. (Pubitemid 40835947)
26. Zhao HY, Liu JM, Ning G, et al. The influence of Lys3Asn polymorphism in the osteoprotegerin gene on bone mineral density in Chinese postmenopausal women. Osteoporos Int. 2005;16:1519-1524.
27. Vidal C, Brincat M, Xuereb AA. TNFRSF11B gene variants and bone mineral density in postmenopausal women in Malta. Maturitas. 2006;53:386-395.
28. Ueland T, Bollerslev J, Wilson SG, et al. No associations between OPG gene polymorphisms or serum levels and measures of osteoporosis in elderly Australian women. Bone. 2007;40:175-181. (Pubitemid 44839322)
29. Garcia-Unzueta MT, Riancho JA, Zarrabeitia MT, et al. Association of the 163A/G and 1181G/C Osteoprotegerin Polymorphism with Bone Mineral Density. Horm Metab Res. 2008;40:219-224.
30. Jurado S, Nogues X, Agueda L, et al. Polymorphisms and haplotypes across the osteoprotegerin gene associated with bone mineral density and osteoporotic fractures. Osteoporos Int. 2010;21:287-296.
31. Moffett SP, Oakley JI, Cauley JA, et al. Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women. J Clin Endocrinol Metab. 2008;93:2002-2008.
32. Dong SS, Liu XG, Chen Y, et al. Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. Calcif Tissue Int. 2009;85:104-112.
33. Zupan J, Mencej-Bedrac S, Jurkovic-Mlakar S, Prezelj J, Marc J. Gene-gene interactions in RANK/RANKL/OPG system influence bone mineral density in postmenopausal women. J Steroid Biochem Mol Biol. 2010;118:102-106.
34. Yerges LM, Klei L, Cauley JA, et al. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. J Bone Miner Res. 2009;24:2039-2049.
35. Yerges LM, Klei L, Cauley JA, et al. Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. J Bone Miner Res. 2010;25:330-338.
36. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med. 2008;358:2355-2365.
37. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, et al. New sequence variants associated with bone mineral density. Nat Genet. 2009;41:15-17.
38. Richards JB, Rivadeneira F, Inouye M, et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet. 2008;371:1505-1512.
39. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263-265. (Pubitemid 40202029)
40. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559-575.
41. Gauderman WJ, Morrison JM. QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies, http://hydra.usc.edu/ gxe, 2006.
42. Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity. 2005;95:221-227. (Pubitemid 43093236)
43. Richards JB, Kavvoura FK, Rivadeneira F, et al. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med. 2009;151:528-537.
44. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Associations between osteoprotegerin polymorphisms and bone mineral density: a meta-analysis. Mol Biol Rep. 2010;37:227-234.