Single Nucleotide Polymorphisms in the Human Gene for Osteoprotegerin are Not Related to Bone Mineral Density or Fracture in Elderly Women

Calcified Tissue International

Volumn 74, Issue 1, 2004, Pages 18-24

  Brandstrom H ^a   Gerdhem, P ^b   Stiger, F ^a   Obrant, K J ^b   Melhus, H ^a   Ljunggren, O ^a   Kindmark, A ^a   Akesson K ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

BMD; Fractures; OPG; Polymorphism; Ultrasound

Indexed keywords

OSTEOPROTEGERIN;

AGED; ANIMAL MODEL; ARTERY CALCIFICATION; ARTICLE; BONE DENSITY; BONE MINERAL; BONE TURNOVER; CALCANEUS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; DNA POLYMORPHISM; ECHOGRAPHY; FEMALE; FRACTURE; GENE; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPG GENE; OSTEOLYSIS; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN;

AGED; BONE DENSITY; CALCANEUS; COHORT STUDIES; FEMALE; FRACTURES, SPONTANEOUS; GLYCOPROTEINS; HUMANS; INCIDENCE; INTRONS; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOPROTEGERIN; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; SWEDEN; ULTRASONOGRAPHY;

EID: 0842348791     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-002-2136-9     Document Type: Article

References (35)

1. Flicker L, et al. (1995) Bone density determinants in elderly women: a twin study. J Bone Miner Res 1011:1607-1613
2. Diaz MN, O'Neill TW, Silman AJ (1997) The influence of family history of hip fracture on the risk of vertebral deformity in men and women: the European Vertebral Osteoporosis Study. Bone 202:145-149
3. Arden NK, et al. (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 114:530-534
4. Ralston SH, et al. (1997) The genetics of osteoporosis. Qjm 904:247-251
5. Simonet WS, et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density [see comments]. Cell 892:309-319
6. Tsuda E, et al. (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 2341:137-142
7. Yasuda H, et al. (1998) Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 1393:1329-1337
8. Bucay N, et al. (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 129:1260-1268
9. Mizuno A, et al. (1998) Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 2473:610-615
10. Price PA, et al. (2001) Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol 2110:1610-1616
11. Morinaga T, et al. (1998) Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor [In Process Citation]. Eur J Biochem 2543:685-691
12. Mack WJ, et al. (2000) Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography. Atherosclerosis 1502:371-379
13. Bots ML, et al. (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 965:1432-1437
14. Rosei EA, et al. (1995) Media: lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance. J Hypertens 133:341-347
15. Karlsson MK, Johnell O, Obrant KJ (1995) Is bone mineral density advantage maintained long-term in previous weight lifters? Calcif Tissue Int 575:325-328
16. Karlsson MK, et al. (1998) Bone mineral density assessed by quantitative ultrasound and dual energy X-ray absorptiometry. Normative data in Malmo, Sweden. Acta Orthop Scand 692:189-193
17. Gerdhem P, et al. (2002) Ultrasound of the phalanges is not related to a previous fracture. A comparison between ultrasound of the phalanges, calcaneus and DXA of the spine and hip in 75-year old women. J Clin Densit (in press)
18. Brandstrom H, et al. (2002) A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function. Biochem Biophys Res Commun 2931:13-17
19. Marie P, et al. (2000) New factors controlling bone remodeling. Joint Bone Spine 673:150-156
20. Hofbauer LC, Heufelder AE (2000) Clinical review 114: hot topic. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases. J Clin Endocrinol Metab 857:2355-2363
21. Aubin JE, Bonnelye E (2000) Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int 1111:905-913
22. Banks LM, et al. (1994) Effect of degenerative spinal and aortic calcification on bone density measurements in postmenopausal women: links between osteoporosis and cardiovascular disease? Eur J Clin Invest 2412:813-817
23. Parhami F, Demer LL (1997) Arterial calcification in face of osteoporosis in ageing: Can we blame oxidized lipids? Curr Opin Lipidol 85:312-314
24. Barengolts EI, et al. (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 623:209-213
25. Frye MA, et al. (1992) Osteoporosis and calcification of the aorta. Bone Miner 192:185-194
26. Reid IR, et al. (1991) The influence of osteophytes and aortic calcification on spinal mineral density in postmenopausal women. J Clin Endocrinol Metab 726:1372-1374
27. Browner WS, Lui LY, Cummings SR (2001) Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J Clin Endocrinol Metab 862:631-637
28. Jono S, et al. (2002) Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation 10610:1192-1194
29. Khosla S, et al. (2002) Correlates of osteoprotegerin levels in women and men. Osteoporos Int 135:394-399
30. Szulc P, et al. (2001) Osteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone status. J Clin Endocrinol Metab 867:3162-3165
31. Langdahl BL, et al. (2002) Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J Bone Miner Res 177:1245-1255
32. Mele R, et al. (1997) Three-year longitudinal study with quantitative ultrasound at the hand phalanx in a female population. Osteoporosis Int 76:550-557
33. Wynne F, et al. (2002) Investigations of the genetic influence of the OPG, VDR (Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population. Calcif Tissue Int 20:20
34. Ohmori H, et al. (2002) Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis. J Hum Genet 478:400-406
35. Arko B, et al. (2002) Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis. J Clin Endocrinol Metab 879:4080-4084