Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study

Journal of Bone and Mineral Research

Volumn 11, Issue 10, 1996, Pages 1531-1538

  Garnero, P ^a   Hausherr, E ^b   Chapuy, M C ^a   Marcelli, C ^c   Grandjean, H ^d   Muller, C ^e   Cormier, C ^b   Breart G ^b   Meunier, P J ^a   Delmas, P D ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b INSERM   (France)

^c LAPEYRONIE HOSPITAL   (France)

^d Serv Univ Psychiat l'Enfant l'A   (France)

^e AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; COLLAGEN TYPE 1; OSTEOCALCIN; PEPTIDE;

AGED; ARTICLE; BONE DENSITY; BONE MINERAL; BONE TURNOVER; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; OSSIFICATION; OSTEOLYSIS; POSTMENOPAUSE; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; URINARY EXCRETION;

EID: 10144251796     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650111021     Document Type: Article

References (42)

1. Cummings SR, Black DM, Rubin SM 1989 Lifetime risks of hip, Colles', or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Inter Med 149:2445-2448.
2. Cummings SR, Nevitt MC, Bowner WS, et al. 1995 Risk factors for hip fracture in white women. New Engl J Med 332:767-773.
3. Grisso JA, Kesley JL, Strom BL, et al. 1991 Risk factors for falls as a cause of hip fracture in women. New Engl J Med 324:1326-1331.
4. Melton III LJ, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL 1993 Long-term fracture prediction by bone mineral density assessed at different skeletal sites. J Bone Miner Res 8:1227-1233.
5. Cummings SR, Black DM, Nevitt MC, et al. 1993 Bone density at various sites for prediction of hip fractures. Lancet 341:72-75.
6. 3 and calcium to prevent hip fractures in elderly women. New Engl J Med 327:1637-1642.
7. Jones G, Nguyen T, Kelly PJ, Eisman JA 1994 Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. Brit Med J 309:691-695.
8. Lips P, Obrant KJ 1991 The pathogenesis and treatment of hip fractures. Osteoporosis Int 1:218-231.
9. Slovik DM, Gundberg CM, Neer RM, Lian JB 1984 Clinical evaluation of bone turnover by serum osteocalcin maesurements in a hospital setting. J Clin Endocrinol Metab 59:228-230.
10. Cooper C, McLaren M, Wood PJ, Coulton L, Kanis JA 1989 Indices of calcium metabolism in women with hip fractures. Bone Miner 6:63-67.
11. Thompson SP, White DA, Hosking DJ, Wilton TJ, Pawley E 1989 Changes in osteocalcin after femoral neck fracture. Ann Clin Biochem 26:487-491.
12. Delmi M, Rapin CH, Bengoa JM, et al. 1990 Dietary supplementation in elderly with fractured neck of femur. Lancet 335:1013-1016.
13. Akesson K, Vergnaud P, Gineyts E, Delmas PD, Obrant KJ 1993 Impairement of bone turnover in elderly women with hip fracture. Calcif Tissue Int 53:162-169.
14. Lips P, Netenbos JC, Jongen MJM, et al. 1982 Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Metab Bone Dis Rel Res 4:85-93.
15. Passeri M, Pallummeri E, Pedrazzoni M, Bia A, Borsalino G, Negri N 1984 Serum osteocalcin variations after hip surgery. In: Christiansen C, et al. (eds.) Osteoporosis 1, Proceedings of the Copenhagen International Symposium on Osteoporosis. Glostrup Hospital, Copenhagen, Denmark, pp. 199-200.
16. Lips P, Bouillon R, Jongen MJ, Van Ginkel FC, Van der Vijgh WJ, Netelenbos JC 1985 The effects of trauma on serum concentrations of vitamin D metabolites in patients with hip fracture. Bone 6:63-67.
17. Plantelech L, Guillaumont M, Leclercq M, Delmas PD 1991 Impaired carboxylation of serum osteocalcin in elderly women. J Bone Miner Res 6:1211-1216.
18. Szulc P, Chapuy M-C, Meunier PJ, Delmas PD 1993 Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91:1769-1774.
19. Garnero P, Grimaux M, Demiaux B, Préaudat C, Seguin P, Delmas PD 1992 Measurement of serum osteocalcin with a human-specific two-site radioimmunoassay. J Bone Miner Res 7:1389-1397.
20. Garnero P, Delmas PD 1993 Assessment of the serum levels of bone akaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab 77:1046-1053.
21. Hanson DA, Weis MAE, Bollen AM, Maslan SH, Singer FR, Eyre DR 1992 A specific immunoassay for monitoring human bone resorption: Quantitation of Type I collagen cross linked N-telopeptides in urine. J Bone Miner Res 7:1251-1258.
22. Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C 1994 Immunoassay for quantifying type I collagen degradation products in urine evaluated. Clin Chem 40:2022-2025.
23. Garnero P, Gineyts E, Riou JP, Delmas PD 1994 Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab 79:780-785.
24. Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ 1994 Direct, enzyme-linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 9:1643-1649.
25. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD 1994 Comparison of new biochemical markers of bone turnover in late postmenopausal women in response to alendronate therapy. J Clin Endocrinol Metab 79:1693-1700.
26. World Health Organisation 1994 Assessment of fracture risk and its application to screening for postmenopausal Osteoporosis. WHO Technical Report Series 843 WHO, Geneva, Switzerland.
27. Delmas PD, Stenner D, Wahner HW, Mann KG, Riggs BL 1983 Increase in serum bone γ-carboxyglutamic acid protein with aging in women. J Clin Invest 71:1316-1321.
28. Epstein S, Poser J, McClintock R, Johnston Jr CC, Bryce G, Hui S 1984 Differences in serum bone gla protein with age and sex. Lancet 2:307-3010.
29. Duda RJ, O'Brien JF, Katzmann JA, Peterson JM, Mann KG, Riggs BL 1988 Concurrent assays of circulating bone glaprotein and bone alkaline phosphatase: Effects of sex, age, and metabolic bone disease. J Clin Endocrinol Metab 66:951-957.
30. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD 1996 Increased bone turnover is a major determinant of osteoporosis in elderly women. J Bone Miner Res 3:337-349.
31. Lips P, Courpron P, Meunier PJ 1978 Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age. Calcif Tissue Res 26:13-17.
32. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationship between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396.
33. Arlot M, Edouard C, Meunier PJ, Neer RM, Reeve J 1984 Impaired osteoblast function in osteoporosis: Comparison between calcium balance and dynamic histomorphometry. Br Med J 289:517-520.
34. Johansen J, Riis BJ, Delmas PD, Christiansen C 1988 Plasma BGP: an indicator of spontaneaous bone loss and the effect of estrogen treatment in postmenopausal women. Eur J Clin Invest 18:191-195.
35. Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD 1991 Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab 72:367-373.
36. Hansen MA, Kirsten O, Riis BJ, Christiansen C 1991 Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 years study. Br Med J 303:961-964.
37. Neaton JD, Wentworth D 1992 Serum cholesterol, blood pressure, cigarette smoking, and death from coronary artery disease: Overall findings and differences by age for 316,099 white men. Arch Intern Med 152:56-64.
38. Lips P, van Ginkel FC, Netelenbos C, Wiersinga A, van ded Vigh WJF 1990 Lower mobility and markers of bone resorption in the elderly. Bone Miner 9:49-57.
39. Dargent P, Favier F, Grandjean H, et al. 1996 Fall-related risk factors for hip fractures: Results from the Epidos prospective study. Lancet 38:145-149.
40. van Daele PLA, Seibel MJ, Burger H, et al. 1996 Case-control analysis of bone resorption markers, disability and hip fracture risk: The Rotterdam study. Br Med J 312:482-483.
41. van Daele PLA, Seibel MJ, Burger H, et al. 1996 Evidence for uncoupling of bone formation and bone resorption in women with hip fractures: A prospective study. Osteoporosis Int 6(Suppl 1):199.
42. 1991 Consensus development conference: Diagnosis, prophylaxis and treatment of Osteoporosis. Am J Med 90:107-110.