Heritability of BMD of femoral neck and lumbar spine: A multivariate twin study of Finnish men

Journal of Bone and Mineral Research

Volumn 22, Issue 9, 2007, Pages 1455-1462

  Videman, Tapio ^a   Levälahti, Esko ^b   Battié, Michele C ^a   Simonen, Riitta ^b   Vanninen, Esko ^c   Kaprio, Jaakko ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF HELSINKI   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Exercise; Genetic research; Mechanical loading; Muscle; Osteoporosis; Twins

Indexed keywords

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BIOMECHANICS; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE STRENGTH; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMUR NECK; FINLAND; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; HUMAN; LEAN BODY WEIGHT; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; STATISTICAL SIGNIFICANCE; TWINS; FEMUR HEAD; GENETICS; HISTOLOGY; LUMBAR VERTEBRA;

BONE DENSITY; FEMUR HEAD; HUMANS; LUMBAR VERTEBRAE; MALE; MULTIVARIATE ANALYSIS;

EID: 36048989113     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070606     Document Type: Article

References (43)

1. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S 1987 Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80:706-710.
2. Arden NK, Spector TD 1997 Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study. J Bone Miner Res 12:2076-2081.
3. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G 1987 Genetic determinants of bone mineral content at the spine and radius: A twin study. Bone 8:207-209.
4. Flicker L, Hopper JL, Rodgers L, Kaymakci B, Green RM, Wark JD 1995 Bone density determinants in elderly women: A twin study. J Bone Miner Res 10:1607-1613.
5. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CC Jr 1991 Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res 6:561-567.
6. Harris M, Nguyen TV, Howard GM, Kelly PJ, Eisman JA 1998 Genetic and environmental correlations between bone formation and bone mineral density: A twin study. Bone 22:141-145.
7. Seeman E, Hopper JL, Young NR, Formica C, Goss P, Tsalamandris C 1996 Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. Am J Physiol 270:E320-E327.
8. Christian JC, Yu PL, Slemenda CW, Johnston CC Jr 1989 Heritability of bone mass: A longitudinal study in aging male twins. Am J Hum Genet 44:429-433.
9. Hopper JL, Green RM, Nowson CA, Young D, Sherwin AJ. Kaymakci B, Larkins RG, Wark JD 1998 Genetic, common environment, and individual specific components of variance for bone mineral density in 10- to 26-year-old females: A twin study. Am J Epidemiol 147:17-29.
10. Kelly PJ, Nguyen T, Hopper J, Pocock N, Sambrook P, Eisman J 1993 Changes in axial bone density with age: A twin study. J Bone Miner Res 8:11-17.
11. Knapp KM, Andrew T, MacGregor AJ, Blake GM, Fogelman I, Spector TD 2003 An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins. J Bone Miner Res 18:1525-1530.
12. Slemenda CW, Turner CH, Peacock M, Christian JC, Sorbel J, Hui SL, Johnston CC 1996 The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. Osteoporos Int 6:178-182.
13. Garabedian M 1995 Genetic aspects of osteoporosis. Curr Opin Rheumatol 7:237-239.
14. Krall EA, Dawson-Hughes B 1993 Heritable and life-style determinants of bone mineral density. J Bone Miner Res 8:1-9.
15. Nguyen TV, Howard GM, Kelly PJ, Eisman JA 1998 Bone mass, lean mass, and fat mass: Same genes or same environments? Am J Epidemiol 147:3-16.
16. Slemenda CW 1995 Body composition and skeletal density-mechanical loading or something more? J Clin Endocrinol Metab 80:1761-1763.
17. Smerdely P, Seller M, Smith A, Day P, Diamond T 2000 Predictors of bone mass in healthy older men in the community. Med J Aust 173:183-186.
18. Henderson NK, Price RI, Cole JH, Gutteridge DH, Bhagat CI 1995 Bone density in young women is associated with body weight and muscle strength but not dietary intakes. J Bone Miner Res 10:384-393.
19. Janssen I, Heymsfield SB, Baumgartner RN, Ross R 2000 Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 89:465-471.
20. Cooper GS, Umbach DM 1996 Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res 11:1841-1849.
21. Liu YZ, Liu YJ, Recker RR, Deng HW 2003 Molecular studies of identification of genes for osteoporosis: The 2002 update. J Endocrinol 177:147-196.
22. Decastro JM 1993 Genetic influences on daily intake and meal patterns of humans. Physiol Behav 53:777-782.
23. Decastro JM 1993 A twin study of genetic and environmental influences on the intake of fluids and beverages. Physiol Behav 54:677-687.
24. Simonen RL, Videman T, Kaprio J, Levalähti E, Battié MC 2003 Factors associated with exercise lifestyle - a study of monozygotic twins. Int J Sports Med 24:499-505.
25. Ropponen A, Levälahti E, Videman T, Kaprio J, Battié MC 2004 The role of genetics and environment in lifting force and isometric trunk extensor endurance. Phys Ther 84:608-621.
26. Bouchard C, Perusse L, Leblanc C, Tremblay A, Theriault G 1988 Inheritance of the amount and distribution of human body fat. Int J Obes 12:205-215.
27. Battié MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K 1995 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 20:2601-2612.
28. Simonen R, Levälahti E, Kaprio J, Videman T, Battié MC 2004 Multivariate genetic analysis of lifetime exercise and environmental factors. Med Sci Sports Exerc 36:1559-1566.
29. Kroger H, Huopio J, Heikkinen J, Laitinen K, Kotaniemi A 1993 [Bone density reference values in Finnish women]. Duodecim 109:578-584.
30. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
31. Kleemola P, Virtanen M, Pietinen P 1994 The 1992 dietary survey of Finnish adults, Department of Clinical Nutrition, National Public Health Institute, Helsinki, Finland.
32. Kaprio J, Koskenvuo M, Langinvainio H, Romanov K, Sarna S, Rose RJ 1987 Genetic influences on use and abuse of alcohol: A study of 5638 adult Finnish twin brothers. Alcohol Clin Exp Res 11:349-356.
33. Romanov K, Rose RJ, Kaprio J, Koskenvuo M, Langinvainio H, Sarna S 1987 Self-reported alcohol use: A longitudinal study of 12,994 adults. Alcohol Alcohol Suppl 1:619-623.
34. Videman T, Battié MC, Gibbons LE, Vanninen E, Kaprio J, Koskenvuo M 2002 The roles of adulthood behavioural factors and familial influences in bone density among men. Ann Med 34:434-443.
35. Ropponen A, Levälahti E, Simonen R, Videman T, Battié MC 2001 Repeatability of lifetime exercise reporting. Scand J Med Sci Sports 11:185-192.
36. Gibbons LE, Videman T, Battié MC 1997 Determinants of isokinetic and psychophysical lifting strength and static back muscle endurance: A study of male monozygotic twins. Spine 22:2983-2990.
37. Van Loan MD 1990 Bioelectrical impedance analysis to determine fat-free mass, total body water and body fat. Sports Med 10:205-217.
38. Williams RL 2000 A note on robust variance estimation for cluster-correlated data. Biometrics 56:645-646.
39. Stata Corporation 2005 Stata Statistical software: Release 9.1. College Station, TX, USA.
40. Neale MC 1994 Mx: Statistical Modeling, 2nd ed. Department of Human Genetics, Medical College of Virginia, Richmond, VA, USA.
41. Beunen G, Thomis M 1999 Genetic determinants of sports participation and daily physical activity. Int J Obes Relat Metab Disord 23(Suppl 3):S55-S63.
42. Lauderdale DS, Fabsitz R, Meyer JM, Sholinsky P, Ramakrishnan V, Goldberg J 1997 Familial determinants of moderate and intense physical activity: A twin study. Med Sci Sports Exerc 29:1062-1068.
43. Deng HW, Livshits G, Yakovenko K, Xu FH, Conway T, Davies KM, Deng H, Recker RR 2002 Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Ann Hum Genet 66:61-74.