-
1
-
-
47249160783
-
Ewing sarcoma: Historical perspectives, current state-of-the- art, and opportunities for targeted therapy in the future
-
Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the- art, and opportunities for targeted therapy in the future. Curr Opin Oncol 2008;20:412-8.
-
(2008)
Curr Opin Oncol
, vol.20
, pp. 412-418
-
-
Ludwig, J.A.1
-
2
-
-
0027932782
-
The Ewing family of tumors - A subgroup of small-round-cell tumors defined by specific chimeric transcripts
-
Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994;331:294-9.
-
(1994)
N Engl J Med
, vol.331
, pp. 294-299
-
-
Delattre, O.1
Zucman, J.2
Melot, T.3
-
4
-
-
17044415589
-
Context matters: The hen or egg problem in Ewing's sarcoma
-
Kovar H. Context matters: the hen or egg problem in Ewing's sarcoma. Semin Cancer Biol 2005;15:189-96.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 189-196
-
-
Kovar, H.1
-
5
-
-
0026686674
-
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
-
Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992;359:162-5.
-
(1992)
Nature
, vol.359
, pp. 162-165
-
-
Delattre, O.1
Zucman, J.2
Plougastel, B.3
-
6
-
-
0027362619
-
The Ewing's sarcoma EWS/ FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
-
May WA, Lessnick SL, Braun BS, et al. The Ewing's sarcoma EWS/ FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 1993;13:7393-8.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7393-7398
-
-
May, W.A.1
Lessnick, S.L.2
Braun, B.S.3
-
7
-
-
0028209984
-
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
-
Bailly RA, Bosselut R, Zucman J, et al. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 1994; 14:3230-41.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 3230-3241
-
-
Bailly, R.A.1
Bosselut, R.2
Zucman, J.3
-
8
-
-
0034528661
-
Variability in gene expression patterns of Ewing tumor cell lines differing in EWS-FLI1 fusion type
-
Aryee DN, Sommergruber W, Muehlbacher K, Dockhorn-Dworniczak B, Zoubek A, Kovar H. Variability in gene expression patterns of Ewing tumor cell lines differing in EWS-FLI1 fusion type. Lab Invest 2000; 80:1833-44.
-
(2000)
Lab Invest
, vol.80
, pp. 1833-1844
-
-
Aryee, D.N.1
Sommergruber, W.2
Muehlbacher, K.3
Dockhorn-Dworniczak, B.4
Zoubek, A.5
Kovar, H.6
-
9
-
-
0034954414
-
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
-
Khan J, Wei JS, Ringner M, et al. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 2001;7:673-9.
-
(2001)
Nat Med
, vol.7
, pp. 673-679
-
-
Khan, J.1
Wei, J.S.2
Ringner, M.3
-
10
-
-
33744502102
-
Ewing's sarcoma oncoprotein EWS-FLI1: The perfect target without a therapeutic agent
-
Uren A, Toretsky JA. Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. Future Oncol 2005;1:521-8.
-
(2005)
Future Oncol
, vol.1
, pp. 521-528
-
-
Uren, A.1
Toretsky, J.A.2
-
11
-
-
0034637482
-
The splicing factor U1C represses EWS/FLI-mediated transactivation
-
Knoop LL, Baker SJ. The splicing factor U1C represses EWS/FLI-mediated transactivation. J Biol Chem 2000;275:24865-71.
-
(2000)
J Biol Chem
, vol.275
, pp. 24865-24871
-
-
Knoop, L.L.1
Baker, S.J.2
-
12
-
-
6344280796
-
Recombinant EWS-FLI1 on-coprotein activates transcription
-
Uren A, Tcherkasskaya O, Toretsky JA. Recombinant EWS-FLI1 on-coprotein activates transcription. Biochemistry 2004;43:13579-89.
-
(2004)
Biochemistry
, vol.43
, pp. 13579-13589
-
-
Uren, A.1
Tcherkasskaya, O.2
Toretsky, J.A.3
-
13
-
-
33846317372
-
Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
-
Ng KP, Potikyan G, Savene RO, Denny CT, Uversky VN, Lee KA. Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A 2007;104:479-84.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 479-484
-
-
Ng, K.P.1
Potikyan, G.2
Savene, R.O.3
Denny, C.T.4
Uversky, V.N.5
Lee, K.A.6
-
14
-
-
17044370533
-
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin
-
Siligan C, Ban J, Bachmaier R, et al. EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. Oncogene 2005;24:2512-24.
-
(2005)
Oncogene
, vol.24
, pp. 2512-2524
-
-
Siligan, C.1
Ban, J.2
Bachmaier, R.3
-
15
-
-
33748136968
-
Microarray analysis of sarcomas
-
Nielsen TO. Microarray analysis of sarcomas. Adv Anat Pathol 2006; 13:166-73.
-
(2006)
Adv Anat Pathol
, vol.13
, pp. 166-173
-
-
Nielsen, T.O.1
-
16
-
-
63449094491
-
An amphipathic α-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function
-
Liu L, Westler WM, den Boon JA, et al. An amphipathic α-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function. PLoS Pathog 2009;5:e1000351.
-
(2009)
PLoS Pathog
, vol.5
-
-
Liu, L.1
Westler, W.M.2
Den Boon, J.A.3
-
17
-
-
0034570889
-
Intrinsic protein disorder in complete genomes
-
Dunker AK, Obradovic Z, Romero P, Garner EC, Brown CJ. Intrinsic protein disorder in complete genomes. Genome Inform Ser Workshop Genome Inform 2000;11:161-71.
-
(2000)
Genome Inform Ser Workshop Genome Inform
, vol.11
, pp. 161-171
-
-
Dunker, A.K.1
Obradovic, Z.2
Romero, P.3
Garner, E.C.4
Brown, C.J.5
-
18
-
-
1542358787
-
Prediction and functional analysis of native disorder in proteins from the three kingdoms of life
-
Ward JJ, Sodhi JS, McGuffin LJ, Buxton BF, Jones DT. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J Mol Biol 2004;337:635-45.
-
(2004)
J Mol Biol
, vol.337
, pp. 635-645
-
-
Ward, J.J.1
Sodhi, J.S.2
McGuffin, L.J.3
Buxton, B.F.4
Jones, D.T.5
-
19
-
-
56649112976
-
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
-
Mittag T, Orlicky S, Choy WY, et al. Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A 2008;105:17772-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17772-17777
-
-
Mittag, T.1
Orlicky, S.2
Choy, W.Y.3
-
20
-
-
48249097986
-
Intrinsically disordered proteins in human diseases: Introducing the D2 concept
-
Uversky VN, Oldfield CJ, Dunker AK. Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys 2008;37:215-46.
-
(2008)
Annu Rev Biophys
, vol.37
, pp. 215-246
-
-
Uversky, V.N.1
Oldfield, C.J.2
Dunker, A.K.3
-
21
-
-
70350449017
-
CT and MRI features of peripheral primitive neuroectodermal tumor
-
Article in Chinese
-
Zhang WD, Xie CM, Mo YX, Li JY. [CT and MRI features of peripheral primitive neuroectodermal tumor] [Article in Chinese]. Ai Zheng 2007; 26:643-6.
-
(2007)
Ai Zheng
, vol.26
, pp. 643-646
-
-
Zhang, W.D.1
Xie, C.M.2
Mo, Y.X.3
Li, J.Y.4
-
22
-
-
0031022241
-
FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements
-
Watson DK, Robinson L, Hodge DR, Kola I, Papas TS, Seth A. FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene 1997;14:213-21.
-
(1997)
Oncogene
, vol.14
, pp. 213-221
-
-
Watson, D.K.1
Robinson, L.2
Hodge, D.R.3
Kola, I.4
Papas, T.S.5
Seth, A.6
-
23
-
-
33645237099
-
Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins
-
Kim S, Denny CT, Wisdom R. Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol 2006;26:2467-78.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2467-2478
-
-
Kim, S.1
Denny, C.T.2
Wisdom, R.3
-
24
-
-
0035393826
-
The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1
-
Arvand A, Welford SM, Teitell MA, Denny CT. The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Cancer Res 2001;61:5311-7.
-
(2001)
Cancer Res
, vol.61
, pp. 5311-5317
-
-
Arvand, A.1
Welford, S.M.2
Teitell, M.A.3
Denny, C.T.4
-
25
-
-
0031935157
-
EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: Interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes
-
Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol Cell Biol 1998;18:1489-97.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1489-1497
-
-
Bertolotti, A.1
Melot, T.2
Acker, J.3
Vigneron, M.4
Delattre, O.5
Tora, L.6
-
26
-
-
0032490843
-
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II
-
Petermann R, Mossier BM, Aryee DN, Khazak V, Golemis EA, Kovar H. Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Oncogene 1998;17:603-10.
-
(1998)
Oncogene
, vol.17
, pp. 603-610
-
-
Petermann, R.1
Mossier, B.M.2
Aryee, D.N.3
Khazak, V.4
Golemis, E.A.5
Kovar, H.6
-
27
-
-
0034353182
-
EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing
-
Yang L, Chansky HA, Hickstein DD. EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing. J Biol Chem 2000;275:37612-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 37612-37618
-
-
Yang, L.1
Chansky, H.A.2
Hickstein, D.D.3
-
28
-
-
4844224145
-
Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1
-
Ramakrishnan R, Fujimura Y, Zou JP, et al. Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene 2004;23:7087-94.
-
(2004)
Oncogene
, vol.23
, pp. 7087-7094
-
-
Ramakrishnan, R.1
Fujimura, Y.2
Zou, J.P.3
-
29
-
-
0038689323
-
Identification of p21WAF1/ CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein
-
Nakatani F, Tanaka K, Sakimura R, et al. Identification of p21WAF1/ CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein. J Biol Chem 2003;278:15105-15.
-
(2003)
J Biol Chem
, vol.278
, pp. 15105-15115
-
-
Nakatani, F.1
Tanaka, K.2
Sakimura, R.3
-
30
-
-
0037101807
-
Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway
-
Spahn L, Petermann R, Siligan C, Schmid JA, Aryee DN, Kovar H. Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway. Cancer Res 2002;62:4583-7.
-
(2002)
Cancer Res
, vol.62
, pp. 4583-4587
-
-
Spahn, L.1
Petermann, R.2
Siligan, C.3
Schmid, J.A.4
Aryee, D.N.5
Kovar, H.6
-
31
-
-
33745289012
-
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase a
-
Toretsky JA, Erkizan V, Levenson A, et al. Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Res 2006;66: 5574-81.
-
(2006)
Cancer Res
, vol.66
, pp. 5574-5581
-
-
Toretsky, J.A.1
Erkizan, V.2
Levenson, A.3
-
32
-
-
0030967951
-
RNA helicase a mediates association of CBP with RNA polymerase II
-
Nakajima T, Uchida C, Anderson SF, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell 1997;90:1107-12.
-
(1997)
Cell
, vol.90
, pp. 1107-1112
-
-
Nakajima, T.1
Uchida, C.2
Anderson, S.F.3
-
33
-
-
33744931657
-
RNA helicase a is necessary for translation of selected messenger RNAs
-
Hartman TR, Qian S, Bolinger C, Fernandez S, Schoenberg DR, Boris-Lawrie K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol 2006;13:509-16.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 509-516
-
-
Hartman, T.R.1
Qian, S.2
Bolinger, C.3
Fernandez, S.4
Schoenberg, D.R.5
Boris-Lawrie, K.6
-
34
-
-
67650447477
-
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase a inhibits growth of Ewing's sarcoma
-
Erkizan HV, Kong Y, Merchant M, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med 2009;15:750-6.
-
(2009)
Nat Med
, vol.15
, pp. 750-756
-
-
Erkizan, H.V.1
Kong, Y.2
Merchant, M.3
-
35
-
-
33644537353
-
The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors
-
Mendiola M, Carrillo J, Garcia E, et al. The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors. Int J Cancer 2006;118:1381-9.
-
(2006)
Int J Cancer
, vol.118
, pp. 1381-1389
-
-
Mendiola, M.1
Carrillo, J.2
Garcia, E.3
-
36
-
-
33845344030
-
NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
-
Kinsey M, Smith R, Lessnick SL. NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res 2006;4:851-9.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 851-859
-
-
Kinsey, M.1
Smith, R.2
Lessnick, S.L.3
-
37
-
-
53649107137
-
DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells
-
Garcia-Aragoncillo E, Carrillo J, Lalli E, et al. DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells. Oncogene 2008;27:6034-43.
-
(2008)
Oncogene
, vol.27
, pp. 6034-6043
-
-
Garcia-Aragoncillo, E.1
Carrillo, J.2
Lalli, E.3
-
38
-
-
71549134306
-
EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma
-
Kinsey M, Smith R, Iyer AK, McCabe ER, Lessnick SL. EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Cancer Res 2009;69: 9047-55.
-
(2009)
Cancer Res
, vol.69
, pp. 9047-9055
-
-
Kinsey, M.1
Smith, R.2
Iyer, A.K.3
McCabe, E.R.4
Lessnick, S.L.5
-
39
-
-
0035933847
-
EWS/FLI alters 5′-splice site selection
-
Knoop LLBS. EWS/FLI alters 5′-splice site selection. J Biol Chem 2001;276:22317-22.
-
(2001)
J Biol Chem
, vol.276
, pp. 22317-22322
-
-
Llbs, K.1
-
40
-
-
0035328667
-
Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein
-
Chansky HA, Hu M, Hickstein DD, Yang L. Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein. Cancer Res 2001;61:3586-90.
-
(2001)
Cancer Res
, vol.61
, pp. 3586-3590
-
-
Chansky, H.A.1
Hu, M.2
Hickstein, D.D.3
Yang, L.4
-
41
-
-
43149105398
-
Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
-
Sanchez G, Bittencourt D, Laud K, et al. Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer. Proc Natl Acad Sci U S A 2008;105:6004-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6004-6009
-
-
Sanchez, G.1
Bittencourt, D.2
Laud, K.3
-
42
-
-
70349972615
-
Analysis of Ewing sarcoma (EWS)-binding proteins: Interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes
-
Pahlich S, Quero L, Roschitzki B, Leemann-Zakaryan RP, Gehring H. Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes. J Proteome Res 2009;8:4455-65.
-
(2009)
J Proteome Res
, vol.8
, pp. 4455-4465
-
-
Pahlich, S.1
Quero, L.2
Roschitzki, B.3
Leemann-Zakaryan, R.P.4
Gehring, H.5
-
43
-
-
62149139782
-
Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage
-
Klevernic IV, Morton S, Davis RJ, Cohen P. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. Biochem J 2009;418:625-34.
-
(2009)
Biochem J
, vol.418
, pp. 625-634
-
-
Klevernic, I.V.1
Morton, S.2
Davis, R.J.3
Cohen, P.4
-
44
-
-
62049084331
-
O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma
-
Bachmaier R, Aryee DN, Jug G, et al. O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma. Oncogene 2009;28:1280-4.
-
(2009)
Oncogene
, vol.28
, pp. 1280-1284
-
-
Bachmaier, R.1
Aryee, D.N.2
Jug, G.3
-
45
-
-
65549090018
-
A molecular function map of Ewing's sarcoma
-
Kauer M, Ban J, Kofler R, et al. A molecular function map of Ewing's sarcoma. PLoS ONE 2009;4:e5415-7.
-
(2009)
PLoS ONE
, vol.4
-
-
Kauer, M.1
Ban, J.2
Kofler, R.3
-
46
-
-
42049089299
-
EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
-
Riggi N, Suva ML, Suva D, et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 2008;68:2176-85.
-
(2008)
Cancer Res
, vol.68
, pp. 2176-2185
-
-
Riggi, N.1
Suva, M.L.2
Suva, D.3
-
47
-
-
65249101694
-
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
-
Richter GH, Plehm S, Fasan A, et al. EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation. Proc Natl Acad Sci U S A 2009;106:5324-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5324-5329
-
-
Richter, G.H.1
Plehm, S.2
Fasan, A.3
-
48
-
-
33750570283
-
Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
-
Tirado OM, Mateo-Lozano S, Villar J, et al. Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res 2006; 66:9937-47.
-
(2006)
Cancer Res
, vol.66
, pp. 9937-9947
-
-
Tirado, O.M.1
Mateo-Lozano, S.2
Villar, J.3
-
49
-
-
57749101153
-
EWS-Fli1 up-regulates expression of the Aurora a and Aurora B kinases
-
Wakahara K, Ohno T, Kimura M, et al. EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases. Mol Cancer Res 2008;6:1937-45.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1937-1945
-
-
Wakahara, K.1
Ohno, T.2
Kimura, M.3
-
50
-
-
10744231438
-
EWS/ETS fusions activate telomerase in Ewing's tumors
-
Takahashi A, Higashino F, Aoyagi M, et al. EWS/ETS fusions activate telomerase in Ewing's tumors. Cancer Res 2003;63:8338-44.
-
(2003)
Cancer Res
, vol.63
, pp. 8338-8344
-
-
Takahashi, A.1
Higashino, F.2
Aoyagi, M.3
-
51
-
-
0041672262
-
Functional analysis of the EWS/ETS target gene uridine phosphorylase
-
Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res 2003;63:4268-74.
-
(2003)
Cancer Res
, vol.63
, pp. 4268-4274
-
-
Deneen, B.1
Hamidi, H.2
Denny, C.T.3
-
52
-
-
70450184674
-
GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
-
Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, Lessnick SL. GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene 2009;28:4126-32.
-
(2009)
Oncogene
, vol.28
, pp. 4126-4132
-
-
Luo, W.1
Gangwal, K.2
Sankar, S.3
Boucher, K.M.4
Thomas, D.5
Lessnick, S.L.6
-
53
-
-
23044503962
-
Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells
-
Nozawa S, Ohno T, Banno Y, et al. Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells. J Biol Chem 2005;280:27544-51.
-
(2005)
J Biol Chem
, vol.280
, pp. 27544-27551
-
-
Nozawa, S.1
Ohno, T.2
Banno, Y.3
-
54
-
-
44349145643
-
The EWS/FLI1 oncogenic transcription factor deregulates GLI1
-
Zwerner JP, Joo J, Warner KL, et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 2008;27:3282-91.
-
(2008)
Oncogene
, vol.27
, pp. 3282-3291
-
-
Zwerner, J.P.1
Joo, J.2
Warner, K.L.3
-
55
-
-
66149131842
-
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
-
Beauchamp E, Bulut G, Abaan O, et al. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem 2009;284:9074-82.
-
(2009)
J Biol Chem
, vol.284
, pp. 9074-9082
-
-
Beauchamp, E.1
Bulut, G.2
Abaan, O.3
-
56
-
-
0030695913
-
The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
-
Toretsky JA, Kalebic T, Blakesley V, LeRoith D, Helman LJ. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem 1997;272:30822-7.
-
(1997)
J Biol Chem
, vol.272
, pp. 30822-30827
-
-
Toretsky, J.A.1
Kalebic, T.2
Blakesley, V.3
LeRoith, D.4
Helman, L.J.5
-
57
-
-
0031025207
-
EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells
-
Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 1997;99:239-47.
-
(1997)
J Clin Invest
, vol.99
, pp. 239-247
-
-
Tanaka, K.1
Iwakuma, T.2
Harimaya, K.3
Sato, H.4
Iwamoto, Y.5
-
58
-
-
0031040025
-
Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides
-
Toretsky JA, Connell Y, Neckers L, Bhat NK. Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides. J Neurooncol 1997;31:9-16.
-
(1997)
J Neurooncol
, vol.31
, pp. 9-16
-
-
Toretsky, J.A.1
Connell, Y.2
Neckers, L.3
Bhat, N.K.4
-
59
-
-
0028826420
-
Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts
-
Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ES. Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene 1995;11:1049-54.
-
(1995)
Oncogene
, vol.11
, pp. 1049-1054
-
-
Ouchida, M.1
Ohno, T.2
Fujimura, Y.3
Rao, V.N.4
Reddy, E.S.5
-
60
-
-
0029829794
-
EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro
-
Kovar H, Aryee DN, Jug G, et al. EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro. Cell Growth Differ 1996;7:429-37.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 429-437
-
-
Kovar, H.1
Aryee, D.N.2
Jug, G.3
-
61
-
-
1342268523
-
Therapeutic potentialities of EWS-Fli-1 mRNA-targeted vectorized antisense oligonucleotides
-
Maksimenko A, Lambert G, Bertrand JR, Fattal E, Couvreur P, Malvy C. Therapeutic potentialities of EWS-Fli-1 mRNA-targeted vectorized antisense oligonucleotides. Ann N Y Acad Sci 2003;1002:72-7.
-
(2003)
Ann N Y Acad Sci
, vol.1002
, pp. 72-77
-
-
Maksimenko, A.1
Lambert, G.2
Bertrand, J.R.3
Fattal, E.4
Couvreur, P.5
Malvy, C.6
-
62
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005;65:8984-92.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
63
-
-
33745299723
-
Fatality in mice due to over-saturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to over-saturation of cellular microRNA/short hairpin RNA pathways. Nature 2006;441:537-41.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
-
64
-
-
77955756800
-
Identification of transcription factor inhibitors: A method used to identify small molecules that block EWS-FLI1 transcription activity
-
Philadelphia (PA): AACR; Abstract nr 3805
-
Grohar PJ, Woldemichael G, Griffin L, et al. Identification of transcription factor inhibitors: a method used to identify small molecules that block EWS-FLI1 transcription activity. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research, Denver, CO. 2009, Philadelphia (PA): AACR; 2009. Abstract nr 3805.
-
(2009)
Proceedings of the 100th Annual Meeting of the American Association for Cancer Research, Denver, CO. 2009
-
-
Grohar, P.J.1
Woldemichael, G.2
Griffin, L.3
-
65
-
-
0034684618
-
Regulation of Ets function by protein-protein interactions
-
Li R, Pei H, Watson DK. Regulation of Ets function by protein-protein interactions. Oncogene 2000;19:6514-23.
-
(2000)
Oncogene
, vol.19
, pp. 6514-6523
-
-
Li, R.1
Pei, H.2
Watson, D.K.3
-
66
-
-
18144394737
-
Design and structure of peptide and pepti-domimetic antagonists of protein-protein interaction
-
Sillerud LO, Larson RS. Design and structure of peptide and pepti-domimetic antagonists of protein-protein interaction. Curr Protein Pept Sci 2005;6:151-69.
-
(2005)
Curr Protein Pept Sci
, vol.6
, pp. 151-169
-
-
Sillerud, L.O.1
Larson, R.S.2
-
67
-
-
3342908718
-
Emerging classes of protein-protein interaction inhibitors and new tools for their development
-
Pagliaro L, Felding J, Audouze K, et al. Emerging classes of protein-protein interaction inhibitors and new tools for their development. Curr Opin Chem Biol 2004;8:442-9.
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 442-449
-
-
Pagliaro, L.1
Felding, J.2
Audouze, K.3
-
68
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov 2004;3:301-17.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
69
-
-
35048895357
-
Targeting protein-protein interactions: Lessons from p53/MDM2
-
Murray JK, Gellman SH. Targeting protein-protein interactions: lessons from p53/MDM2. Biopolymers 2007;88:657-86.
-
(2007)
Biopolymers
, vol.88
, pp. 657-686
-
-
Murray, J.K.1
Gellman, S.H.2
-
70
-
-
77952703733
-
Initial testing of the aurora kinase a inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
-
Maris JM, Morton CL, Gorlick R, et al. Initial testing of the aurora kinase a inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr Blood Cancer 2010;55:26-34.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 26-34
-
-
Maris, J.M.1
Morton, C.L.2
Gorlick, R.3
-
71
-
-
77951747892
-
Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
-
Houghton PJ, Morton CL, Gorlick R, et al. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2010;54:921-6.
-
(2010)
Pediatr Blood Cancer
, vol.54
, pp. 921-926
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
-
72
-
-
33947262154
-
Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma
-
Manara MC, Landuzzi L, Nanni P, et al. Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma. Clin Cancer Res 2007;13:1322-30.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1322-1330
-
-
Manara, M.C.1
Landuzzi, L.2
Nanni, P.3
-
73
-
-
75249097799
-
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study
-
Olmos D, Postel-Vinay S, Molife LR, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol 2010;11:129-35.
-
(2010)
Lancet Oncol
, vol.11
, pp. 129-135
-
-
Olmos, D.1
Postel-Vinay, S.2
Molife, L.R.3
|