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Volumn 3, Issue 3, 2010, Pages 271-281

Enniatin B1 is a substrate of intestinal P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein

Author keywords

ABC transporters; Caco 2 cells; Intestinal absorption

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; ENNIATIN; FUMITREMORGIN C; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 2; VERAPAMIL; VERLUKAST;

EID: 77955694673     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2010.1225     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • DOI 10.1016/S0169-409X(00)00128-9, PII S0169409X00001289
    • Artursson, P., Palm, K. and Luthman, K., 2001. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 46: 27-43. (Pubitemid 33653412)
    • (2000) Advanced Drug Delivery Reviews , vol.46 , Issue.1-3 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 2
    • 0037432669 scopus 로고    scopus 로고
    • Interaction of ochratoxin A with human intestinal Caco-2 cells: Possible implication of a multidrug resistance-associated protein (MRP2)
    • Berger, V., Gabriel, A.F., Sergent, T., Trouet, A., Larondelle, Y. and Schneider, Y.J., 2003. Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2). Toxicology Letters 140- 141: 465-476.
    • (2003) Toxicology Letters , vol.140-141 , pp. 465-476
    • Berger, V.1    Gabriel, A.F.2    Sergent, T.3    Trouet, A.4    Larondelle, Y.5    Schneider, Y.J.6
  • 4
    • 0031544690 scopus 로고    scopus 로고
    • Intestinal cell models. Their use in evaluating the metabolism and absorption of xenobiotics
    • Boulenc, X., 1997. Intestinal cell models. Their use in evaluating the metabolism and absorption of xenobiotics. STP Pharma Sciences 7: 259-269.
    • (1997) STP Pharma Sciences , vol.7 , pp. 259-269
    • Boulenc, X.1
  • 5
    • 0000208630 scopus 로고
    • Enniatin production by Fusarium tricinctum and its effect on germinating wheat seeds
    • Burmeister, H.R. and Plattner, R.D., 1987. Enniatin production by Fusarium tricinctum and its effect on germinating wheat seeds. Physiology and Biochemistry 77: 1483-1487
    • (1987) Physiology and Biochemistry , vol.77 , pp. 1483-1487
    • Burmeister, H.R.1    Plattner, R.D.2
  • 6
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • Chan, L.M.S, Lowes, S. and Hirst, B.H., 2004. The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. European Journal of Pharmaceutical Sciences 21: 25-51.
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 7
    • 15944408721 scopus 로고    scopus 로고
    • 1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein
    • DOI 10.1016/j.toxicon.2004.10.015
    • De Angelis, I., Frigge, G., Raimondi, F., Stammati, A., Zucco, F. and Caloni, F., 2005. Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein. Toxicon 45: 285-291. (Pubitemid 40431272)
    • (2005) Toxicon , vol.45 , Issue.3 , pp. 285-291
    • De Angelis, I.1    Frigge, G.2    Raimondi, F.3    Stammati, A.4    Zucco, F.5    Caloni, F.6
  • 11
    • 0033562673 scopus 로고    scopus 로고
    • HIV protease inhibitor ritonavir: A more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833
    • Drewe, J., Gutmann, H., Fricker, G., Török, M., Beglinger, C. and Huwyler, J., 1999. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochemical Pharmacology 57: 1147-1152.
    • (1999) Biochemical Pharmacology , vol.57 , pp. 1147-1152
    • Drewe, J.1    Gutmann, H.2    Fricker, G.3    Török, M.4    Beglinger, C.5    Huwyler, J.6
  • 12
  • 15
    • 0029939665 scopus 로고    scopus 로고
    • Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers
    • Ford, J.M., 1996. Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers. European Journal of Cancer 32A: 991-1001.
    • (1996) European Journal of Cancer , vol.32 A , pp. 991-1001
    • Ford, J.M.1
  • 16
    • 16544380216 scopus 로고    scopus 로고
    • Cytotoxicity of fungal metabolites to lepidopteran (Spodoptera frugiperda) cell line (SF-9)
    • Fornelli, F., Minervini, F. and Logrieco, A., 2004. Cytotoxicity of fungal metabolites to lepidopteran (Spodoptera frugiperda) cell line (SF-9). Journal of Invertebrate Pathology 85: 74-79.
    • (2004) Journal of Invertebrate Pathology , vol.85 , pp. 74-79
    • Fornelli, F.1    Minervini, F.2    Logrieco, A.3
  • 17
    • 0242552872 scopus 로고    scopus 로고
    • Importance of P-glycoprotein for drug disposition in humans
    • Fromm, M.F., 2003. Importance of P-glycoprotein for drug disposition in humans. European Journal of Clinical Investigation 33, Suppl. 2: 6-9.
    • (2003) European Journal of Clinical Investigation , vol.33 , Issue.SUPPL. 2 , pp. 6-9
    • Fromm, M.F.1
  • 18
    • 0031022120 scopus 로고    scopus 로고
    • Applications of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium
    • Gan, L.S. and Thakker, D.R., 1997. Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium. Advanced Drug Delivery Reviews 23: 77-98.
    • (1997) Advanced Drug Delivery Reviews , vol.23 , pp. 77-98
    • Gan, L.S.1    Thakker, D.R.2
  • 21
  • 22
    • 0036889665 scopus 로고    scopus 로고
    • Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
    • Goh, L.B., Spears, K.J., Yao, D., Ayrton, A., Morgan, P., Wolf, R.C. and Friedberg, T., 2002. Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man. Biochemical Pharmacology 64: 1569-1578.
    • (2002) Biochemical Pharmacology , vol.64 , pp. 1569-1578
    • Goh, L.B.1    Spears, K.J.2    Yao, D.3    Ayrton, A.4    Morgan, P.5    Wolf, R.C.6    Friedberg, T.7
  • 23
    • 0018880169 scopus 로고
    • The insecticidal activity of beauvericin and the enniatin complex
    • Grove, J.F. and Pople, M., 1980. The insecticidal activity of beauvericin and the enniatin complex. Mycopathologia 70: 103-105.
    • (1980) Mycopathologia , vol.70 , pp. 103-105
    • Grove, J.F.1    Pople, M.2
  • 24
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo, I.J., Raub, T.J. and Borchardt, R.T., 1989. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96: 736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 25
    • 13744263566 scopus 로고    scopus 로고
    • Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae
    • DOI 10.1016/j.bbrc.2005.01.075
    • Hiraga, K., Yamamoto, S., Fukuda, H., Hamanaka, N. and Oda, K., 2005. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328: 1119-1125. (Pubitemid 40238750)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.4 , pp. 1119-1125
    • Hiraga, K.1    Yamamoto, S.2    Fukuda, H.3    Hamanaka, N.4    Oda, K.5
  • 26
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • Hunter, J. and Hirst, B.H., 1997. Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Advanced Drug Delivery Reviews 25: 129-157.
    • (1997) Advanced Drug Delivery Reviews , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 27
    • 46549085541 scopus 로고    scopus 로고
    • A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures
    • Ivanova, L. and Uhlig, S., 2008. A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Analytical Biochemistry 379: 16-19.
    • (2008) Analytical Biochemistry , vol.379 , pp. 16-19
    • Ivanova, L.1    Uhlig, S.2
  • 28
    • 33744928355 scopus 로고    scopus 로고
    • Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum
    • Ivanova, L., Skjerve, E., Eriksen, G.S. and Uhlig, S., 2006. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. Toxicon 47: 868-876.
    • (2006) Toxicon , vol.47 , pp. 868-876
    • Ivanova, L.1    Skjerve, E.2    Eriksen, G.S.3    Uhlig, S.4
  • 30
    • 4544336349 scopus 로고    scopus 로고
    • Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in Finnish grain samples
    • Jestoi, M., Rokka, M., Yli-Mattila, T., Parikka, P., Rizzo, A. and Peltonen, K., 2004. Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in Finnish grain samples. Food Additives and Contaminants 21: 794-802.
    • (2004) Food Additives and Contaminants , vol.21 , pp. 794-802
    • Jestoi, M.1    Rokka, M.2    Yli-Mattila, T.3    Parikka, P.4    Rizzo, A.5    Peltonen, K.6
  • 32
    • 0034947674 scopus 로고    scopus 로고
    • From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance
    • Litman, T., Druley, T.E., Stein, W.D. and Bates, S.E., 2001. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cellular and Molecular Life Sciences 58: 931-959.
    • (2001) Cellular and Molecular Life Sciences , vol.58 , pp. 931-959
    • Litman, T.1    Druley, T.E.2    Stein, W.D.3    Bates, S.E.4
  • 33
    • 38049039819 scopus 로고    scopus 로고
    • Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein
    • Liu, X.L., Tee, H.W. and Go, M.L., 2008. Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein. Bioorganic and Medicinal Chemistry 16: 171-180.
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , pp. 171-180
    • Liu, X.L.1    Tee, H.W.2    Go, M.L.3
  • 34
    • 0036135167 scopus 로고    scopus 로고
    • Occurrence of beauvericin and enniatins in wheat affected by Fusarium avenaceum head blight
    • Logrieco, A., Rizzo, A., Ferracane, R. and Ritieni, A., 2002. Occurrence of beauvericin and enniatins in wheat affected by Fusarium avenaceum head blight. Applied and Environmental Microbiology 68: 82-85.
    • (2002) Applied and Environmental Microbiology , vol.68 , pp. 82-85
    • Logrieco, A.1    Rizzo, A.2    Ferracane, R.3    Ritieni, A.4
  • 36
    • 11844284860 scopus 로고    scopus 로고
    • Human breast cancer resistance protein: Interaction with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazol(4,5-b) pyridine, and transport of cimetidine
    • Pavec, P., Merino, G., Wagenaar, E., Bolscher, E., Novotna, M., Jonker, J.W. and Schinkel, A.H., 2005. Human breast cancer resistance protein: interaction with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazol(4,5-b)pyridine, and transport of cimetidine. The Journal of Pharmacology and Experimental Therapeutics 312: 144-152.
    • (2005) The Journal of Pharmacology and Experimental Therapeutics , vol.312 , pp. 144-152
    • Pavec, P.1    Merino, G.2    Wagenaar, E.3    Bolscher, E.4    Novotna, M.5    Jonker, J.W.6    Schinkel, A.H.7
  • 38
    • 33846922033 scopus 로고    scopus 로고
    • Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays
    • Pohjala, L., Tammela, P., Samanta, S.K., Yli-Kauhaluoma, J. and Vuorela, P., 2007. Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Analytical Biochemistry 362: 221-228.
    • (2007) Analytical Biochemistry , vol.362 , pp. 221-228
    • Pohjala, L.1    Tammela, P.2    Samanta, S.K.3    Yli-Kauhaluoma, J.4    Vuorela, P.5
  • 39
    • 6344242987 scopus 로고    scopus 로고
    • Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells
    • Prime-Chapman, H.M., Fearn, R.A., Cooper, A.E., Moore, V. and Hirst, B.H., 2004. Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells. The Journal of Pharmacology and Experimental Therapeutics 311: 476-484.
    • (2004) The Journal of Pharmacology and Experimental Therapeutics , vol.311 , pp. 476-484
    • Prime-Chapman, H.M.1    Fearn, R.A.2    Cooper, A.E.3    Moore, V.4    Hirst, B.H.5
  • 40
    • 0033966957 scopus 로고    scopus 로고
    • Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
    • Rabindran, S.K., Ross, D.D., Doyle, L.A., Yang, W. and Greenberger, L.M., 2000. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Research 60: 47-50.
    • (2000) Cancer Research , vol.60 , pp. 47-50
    • Rabindran, S.K.1    Ross, D.D.2    Doyle, L.A.3    Yang, W.4    Greenberger, L.M.5
  • 41
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system
    • Sarkadi, B., Homolya, L., Szakács, G. and Váradi, A., 2006. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiological Reviews 86: 1179-1236.
    • (2006) Physiological Reviews , vol.86 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakács, G.3    Váradi, A.4
  • 42
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel, A.H. and Jonker, J.W. 2003. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced Drug Delivery Reviews 55: 3-29.
    • (2003) Advanced Drug Delivery Reviews , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 43
    • 33747090656 scopus 로고    scopus 로고
    • Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
    • Seithel, A., Karlsson, J., Hilgendorf, C., Björquist, A. and Ungell, A.L., 2006. Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells. European Journal of Pharmaceutical Sciences 28: 291-299.
    • (2006) European Journal of Pharmaceutical Sciences , vol.28 , pp. 291-299
    • Seithel, A.1    Karlsson, J.2    Hilgendorf, C.3    Björquist, A.4    Ungell, A.L.5
  • 45
    • 0011987451 scopus 로고
    • Beauvericin and the other enniatins
    • Sigel, H. (ed.). Marcel Dekker, New York, NY, USA
    • Steinrauf, L., 1985. Beauvericin and the other enniatins. In: Sigel, H. (ed.) Metal ions in biological systems, volume 19. Marcel Dekker, New York, NY, USA, pp. 139-171.
    • (1985) Metal Ions in Biological Systems , vol.19 , pp. 139-171
    • Steinrauf, L.1
  • 46
    • 0023877155 scopus 로고
    • Enniatins from Fusarium avenaceum isolated from balsam fir foliage and their toxicity to spruce budworm larvae, Choristoneura fumiferana (Clem.) (Lepidoptera: Tortricidae)
    • Strongman, D.B., Strunz, G.M., Giguere, P., Yu, C.M. and Calhoun, L., 1988. Enniatins from Fusarium avenaceum isolated from balsam fir foliage and their toxicity to spruce budworm larvae, Choristoneura fumiferana (Clem.) (Lepidoptera: Tortricidae). Journal of Chemical Ecology 14: 753-764.
    • (1988) Journal of Chemical Ecology , vol.14 , pp. 753-764
    • Strongman, D.B.1    Strunz, G.M.2    Giguere, P.3    Yu, C.M.4    Calhoun, L.5
  • 47
    • 28444484982 scopus 로고    scopus 로고
    • Expression and function of efflux drug transporters in the intestine
    • Takano, M., Yumoto, R. and Murakami, T., 2006. Expression and function of efflux drug transporters in the intestine. Pharmacology and Therapeutics 109: 137-161.
    • (2006) Pharmacology and Therapeutics , vol.109 , pp. 137-161
    • Takano, M.1    Yumoto, R.2    Murakami, T.3
  • 48
    • 0036298317 scopus 로고    scopus 로고
    • Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
    • DOI 10.1023/A:1016192413308
    • Tang, F., Horie, K. and Borchardt, R.T., 2002a. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharmaceutical Research 19: 773-779. (Pubitemid 34686735)
    • (2002) Pharmaceutical Research , vol.19 , Issue.6 , pp. 773-779
    • Tang, F.1    Horie, K.2    Borchardt, R.T.3
  • 49
    • 0036293772 scopus 로고    scopus 로고
    • Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    • DOI 10.1023/A:1016140429238
    • Tang, F., Horie, K. and Borchardt, R.T., 2002b. Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharmaceutical Research 19: 765-772. (Pubitemid 34686734)
    • (2002) Pharmaceutical Research , vol.19 , Issue.6 , pp. 765-772
    • Tang, F.1    Horie, K.2    Borchardt, R.T.3
  • 50
    • 34248172465 scopus 로고    scopus 로고
    • Transepithelial transport of fusariotoxin nivalenol: Mediation of secretion by ABC transporters
    • Tep, J., Videmann, B., Mazallon, M., Balleydier, S., Cavret, S. and Lecoeur, S., 2007. Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters. Toxicology Letters 170: 248-258.
    • (2007) Toxicology Letters , vol.170 , pp. 248-258
    • Tep, J.1    Videmann, B.2    Mazallon, M.3    Balleydier, S.4    Cavret, S.5    Lecoeur, S.6
  • 51
    • 22044456325 scopus 로고    scopus 로고
    • Identification of cytotoxic principles from Fusarium avenaceum using bioassay-guided fractionation
    • Uhlig, S., Gutleb, A.C., Thrane, U. and Flåøyen, A., 2005. Identification of cytotoxic principles from Fusarium avenaceum using bioassay-guided fractionation. Toxicon 46: 150-159
    • (2005) Toxicon , vol.46 , pp. 150-159
    • Uhlig, S.1    Gutleb, A.C.2    Thrane, U.3    Flåøyen, A.4
  • 53
    • 34547810884 scopus 로고    scopus 로고
    • Epithelial transport of deoxynivalenol: Involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2)
    • Videmann, B., Tep, J., Cavret, S. and Lecoeur, S., 2007. Epithelial transport of deoxynivalenol: involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2). Food and Chemical Toxicology 45: 1938-1947.
    • (2007) Food and Chemical Toxicology , vol.45 , pp. 1938-1947
    • Videmann, B.1    Tep, J.2    Cavret, S.3    Lecoeur, S.4
  • 54
    • 0025189818 scopus 로고
    • Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier
    • Wilson, G., Hassan, I.F., Dix, C.J., Williamson, I., Shah, R., Mackay, M. and Artursson, P., 1990. Transport and permeability properties of human Caco-2 cells: an in vitro model of the intestinal epithelial cell barrier. Journal of Controlled Release 11: 25-40. (Pubitemid 20070083)
    • (1990) Journal of Controlled Release , vol.11 , Issue.1-3 , pp. 25-40
    • Wilson, G.1    Hassan, I.F.2    Dix, C.J.3    Williamson, I.4    Shah, R.5    Mackay, M.6    Artursson, P.7
  • 57
    • 34249038460 scopus 로고    scopus 로고
    • Evaluation of drug-transporter interactions using in vitro and in vivo models
    • Xia, C.Q., Milton, M.N. and Gan, L.S., 2007. Evaluation of drug-transporter interactions using in vitro and in vivo models. Current Drug Metabolism 8: 341-363.
    • (2007) Current Drug Metabolism , vol.8 , pp. 341-363
    • Xia, C.Q.1    Milton, M.N.2    Gan, L.S.3
  • 58
    • 3843067618 scopus 로고    scopus 로고
    • Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06
    • Zeng, H., Lin, Z.P. and Sartorelli, A.C., 2004. Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06. Biochemical Pharmacology 68: 911-921.
    • (2004) Biochemical Pharmacology , vol.68 , pp. 911-921
    • Zeng, H.1    Lin, Z.P.2    Sartorelli, A.C.3
  • 59
    • 0037457790 scopus 로고    scopus 로고
    • In vitro and in vivo models for assessing drug efflux transporter activity
    • Zhang, Y., Bachmeier, G. and Miller, D.W., 2003. In vitro and in vivo models for assessing drug efflux transporter activity. Advanced Drug Delivery Reviews 55: 31-51.
    • (2003) Advanced Drug Delivery Reviews , vol.55 , pp. 31-51
    • Zhang, Y.1    Bachmeier, G.2    Miller, D.W.3


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