Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the holliday junction

Science

Volumn 318, Issue 5848, 2007, Pages 279-283

  Hohng, Sungchul ^a,b,f   Zhou, Ruobo ^a   Nahas, Michelle K ^a   Yu, Jin ^a,d   Schulten, Klaus ^a,c,d   Lilley, David M J ^e   Ha, Taekjip ^a,b,c,d  

^a University of Illinois at Urbana Champaign   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID;

ENZYME; FLUORESCENCE; MOLECULAR ANALYSIS; PROTEIN; SPECTROSCOPY;

ARTICLE; CONFORMATIONAL TRANSITION; FLUORESCENCE SPECTROSCOPY; FORCE; GENE AMPLIFICATION; HOLLIDAY JUNCTION; HYBRID GENE; MOLECULAR SENSOR; PRIORITY JOURNAL; PROTEIN INTERACTION;

BACTERIOPHAGE LAMBDA; BIOPHYSICS; DNA, CRUCIFORM; DNA, VIRAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; NUCLEIC ACID CONFORMATION; OPTICAL TWEEZERS;

EID: 35348897239     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1146113     Document Type: Article

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29. We thank W. Cheng at University of California-Berkeley for providing the protocol for the preparation of anti-Dig coated bead, M. Wang at Cornell University for giving generous advice about building optical tweezers, Y. Chemla at University of Illinois for helpful discussion, and C. Joo for generous help in preparation of illustrations. Funding was provided by the National Sciences Foundation CAREER Award (PHY 0134916) and the National Institutes of Health (GM065367). T.H. is an investigator with the Howard Hughes Medical Institute.