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Volumn 83, Issue 2, 2010, Pages 250-257

Frequency distribution of antimalarial drug resistance alleles among Plasmodium falciparum isolates from Gezira State, Central Sudan, and Gedarif State, Eastern Sudan

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 6; CHLOROQUINE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN CRT; PROTEIN DHPSN; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

EID: 77955647557     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2010.09-0514     Document Type: Article
Times cited : (19)

References (57)
  • 1
    • 0035884456 scopus 로고    scopus 로고
    • Chloroquine-resistant malaria
    • Wellems T, Plowe C, 2001. Chloroquine-resistant malaria. J Infect Dis 184: 770-776.
    • (2001) J Infect Dis , vol.184 , pp. 770-776
    • Wellems, T.1    Plowe, C.2
  • 2
    • 2142659388 scopus 로고    scopus 로고
    • Antimalarial drug resistance
    • White NJ, 2004. Antimalarial drug resistance. J Clin Invest 113: 1084-1092.
    • (2004) J Clin Invest , vol.113 , pp. 1084-1092
    • White, N.J.1
  • 4
    • 1642565140 scopus 로고    scopus 로고
    • Genetic and biochemical aspects of drug resistance in malaria parasites
    • Hayton K, Su XZ, 2004. Genetic and biochemical aspects of drug resistance in malaria parasites. Curr Drug Targets Infect Disord 4: 1-10.
    • (2004) Curr Drug Targets Infect Disord , vol.4 , pp. 1-10
    • Hayton, K.1    Su, X.Z.2
  • 5
    • 14844327986 scopus 로고    scopus 로고
    • In vivo selection of Plasmodium falciparum pfmdrI 86N coding alleles by artemether-lumefantrine (Coartem)
    • Sisowath C, Stromberg J, Martensson A, Msellem M, Obondo C, Björkman A, Gil JP, 2005. In vivo selection of Plasmodium falciparum pfmdrI 86N coding alleles by artemether-lumefantrine (Coartem). J Infect Dis I9I: 1014-1017.
    • (2005) J Infect Dis , vol.9 , pp. 1014-1017
    • Sisowath, C.1    Stromberg, J.2    Martensson, A.3    Msellem, M.4    Obondo, C.5    Björkman, A.6    Gil, J.P.7
  • 6
    • 0031807606 scopus 로고    scopus 로고
    • Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites
    • Basco LK, Tahar R, Ringwald P, 1998. Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites. Antimicrob Agents Chemother 42: 1811-1844.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1811-1844
    • Basco, L.K.1    Tahar, R.2    Ringwald, P.3
  • 7
    • 0000854414 scopus 로고
    • Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
    • Cowman AF, Morry MJ. Biggs BA, Cross GA, Foote SJ, 1988. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 85: 9109-9113.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9109-9113
    • Cowman, A.F.1    Morry, M.J.2    Biggs, B.A.3    Cross, G.A.4    Foote, S.J.5
  • 8
    • 0010600225 scopus 로고    scopus 로고
    • Association between antifol resistance in vitro and DHFR gene point mutation in Plasmodium falciparum isolates
    • de Pecoulas PE, Basco LK, Le Bras J, Mazabraud A. 1996. Association between antifol resistance in vitro and DHFR gene point mutation in Plasmodium falciparum isolates. Trans R Soc Trop Med Hyg 90: 181-182.
    • (1996) Trans R Soc Trop Med Hyg , vol.90 , pp. 181-182
    • De Pecoulas, P.E.1    Basco, L.K.2    Le Bras, J.3    Mazabraud, A.4
  • 9
    • 0029050608 scopus 로고
    • Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: Polymerase chain reaction methods for surveillance in Africa
    • Plowe CV. Djimde A, Bouare M, Doumbo O, Wellems TE, 1995. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52: 565-568.
    • (1995) Am J Trop Med Hyg , vol.52 , pp. 565-568
    • Plowe, C.V.1    Djimde, A.2    Bouare, M.3    Doumbo, O.4    Wellems, T.E.5
  • 12
    • 0033775025 scopus 로고    scopus 로고
    • The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya
    • Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM, 2000. The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. Am J Trop Med Hyg 62: 396-401.
    • (2000) Am J Trop Med Hyg , vol.62 , pp. 396-401
    • Mberu, E.K.1    Mosobo, M.K.2    Nzila, A.M.3    Kokwaro, G.O.4    Sibley, C.H.5    Watkins, W.M.6
  • 13
    • 0034065697 scopus 로고    scopus 로고
    • Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: Genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites
    • Nzila AM, Mberu EK, Sulo J, Dayo H, Winstanley PA, Sibley CH, Watkins WM, 2000. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. Antimicrob Agents Chemother 44: 991-996.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 991-996
    • Nzila, A.M.1    Mberu, E.K.2    Sulo, J.3    Dayo, H.4    Winstanley, P.A.5    Sibley, C.H.6    Watkins, W.M.7
  • 14
    • 0034813570 scopus 로고    scopus 로고
    • Artemisinin and its derivatives: An important new class of antimalarial agents
    • Balint GA, 2001. Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther 90: 261-265.
    • (2001) Pharmacol Ther , vol.90 , pp. 261-265
    • Balint, G.A.1
  • 15
    • 0003588734 scopus 로고    scopus 로고
    • World Health Organization Geneva: World Health Organization, WHO/CDS/RBM/2001.35
    • World Health Organization. 2001. Antimalarial Drug Combination Therapy. Geneva: World Health Organization, WHO/CDS/RBM/2001.35.
    • (2001) Antimalarial Drug Combination Therapy
  • 21
    • 0003973660 scopus 로고    scopus 로고
    • Sudan Available at: Accessed April 28, 2005
    • Sudan. Country Profile. Available at: http://rbm.who.int/wmr2005/ profiles/sudan.pdf. Accessed April 28, 2005.
    • Country Profile
  • 23
    • 0034261559 scopus 로고    scopus 로고
    • Antimalarials prescribing pattern in Gazera State: Precepts and practices
    • Yousif MA, Adeel AA, 2000. Antimalarials prescribing pattern in Gazera State: precepts and practices. East Mediterr Health J 6: 939-947.
    • (2000) East Mediterr Health J , vol.6 , pp. 939-947
    • Yousif, M.A.1    Adeel, A.A.2
  • 24
    • 0018080724 scopus 로고
    • Response of Plasmodium falciparum in Sudan to oral chloroquine
    • Omer AH, 1978. Response of Plasmodium falciparum in Sudan to oral chloroquine. Am J Trop Med Hyg 27: 853-857.
    • (1978) Am J Trop Med Hyg , vol.27 , pp. 853-857
    • Omer, A.H.1
  • 26
    • 0026666007 scopus 로고
    • Assessment of chloroquine resistance of Plasmodium falciparum in children of Wad Medani (central Sudan)
    • Ibrahim AM, Ali FR, Ali ME, 1992. Assessment of chloroquine resistance of Plasmodium falciparum in children of Wad Medani (central Sudan). J Trop Pediatr 38: 162-166.
    • (1992) J Trop Pediatr , vol.38 , pp. 162-166
    • Ibrahim, A.M.1    Ali, F.R.2    Ali, M.E.3
  • 27
    • 33746455615 scopus 로고    scopus 로고
    • In vitro study assessing the response of Plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, Sudan
    • Nour BY, Faragalla IA, Saeed OK, Mohamadani AA, 2006. In vitro study assessing the response of Plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, Sudan. Saudi Med J 27: 808-812.
    • (2006) Saudi Med J , vol.27 , pp. 808-812
    • Nour, B.Y.1    Faragalla, I.A.2    Saeed, O.K.3    Mohamadani, A.A.4
  • 29
    • 19344375700 scopus 로고    scopus 로고
    • Drug resistant Plasmodium falciparum in an area of seasonal transmission
    • Babiker HA, Satti G, Ferguson H, Bayoumi R, Walliker D, 2005. Drug resistant Plasmodium falciparum in an area of seasonal transmission. Acta Trop 94: 260-268.
    • (2005) Acta Trop , vol.94 , pp. 260-268
    • Babiker, H.A.1    Satti, G.2    Ferguson, H.3    Bayoumi, R.4    Walliker, D.5
  • 30
    • 0025781766 scopus 로고
    • A case of Plasmodium falciparum malaria sensitive to chloroquine but resistant to pyrimethamine/sulfadoxine in Sennar, Sudan
    • Ibrahim ME, Awad-el-Kariem FM, el Hassan IM, el Mubarak ER, 1991. A case of Plasmodium falciparum malaria sensitive to chloroquine but resistant to pyrimethamine/sulfadoxine in Sennar, Sudan. Trans R Soc Trop Med Hyg 85: 446.
    • (1991) Trans R Soc Trop Med Hyg , vol.85 , pp. 446
    • Ibrahim, M.E.1    Awad-el-Kariem, F.M.2    El Hassan, I.M.3    El Mubarak, E.R.4
  • 31
    • 48449094768 scopus 로고    scopus 로고
    • High frequency of Plasmodium falciparum CICNI/SGEAA and CVIET haplotypes without association with resistance to sulfadoxine/pyrimethamine and chloroquine combination in the Daraweesh area, in Sudan
    • A-Elbasit IE, Khalil IF, Elbashir MI, Masuadi EM, Bygbjerg IC, Alifrangis M, Giha HA, 2008. High frequency of Plasmodium falciparum CICNI/SGEAA and CVIET haplotypes without association with resistance to sulfadoxine/pyrimethamine and chloroquine combination in the Daraweesh area, in Sudan. Eur J Clin Microbiol Infect Dis 27: 725-732.
    • (2008) Eur J Clin Microbiol Infect Dis , vol.27 , pp. 725-732
    • A-Elbasit, I.E.1    Khalil, I.F.2    Elbashir, M.I.3    Masuadi, E.M.4    Bygbjerg, I.C.5    Alifrangis, M.6    Giha, H.A.7
  • 32
    • 33646262340 scopus 로고    scopus 로고
    • The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural eastern Sudan: The interrelation between resistance, age and gametocytogenesis
    • A-Elbasit IE, Elbashir MI, Khalil IF, Alifrangis M, Giha HA, 2006. The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural eastern Sudan: the interrelation between resistance, age and gametocytogenesis. Trop Med Int Health 11: 604-612.
    • (2006) Trop Med Int Health , vol.11 , pp. 604-612
    • A-Elbasit, I.E.1    Elbashir, M.I.2    Khalil, I.F.3    Alifrangis, M.4    Giha, H.A.5
  • 33
    • 1342332265 scopus 로고    scopus 로고
    • Prediction of Plasmodium falciparum resistance to sulfadoxine/ pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: A comparative study between sites of differing endemicity
    • Alifrangis M, Enosse S, Khalil IF, Tarimo DS, Lemnge MM, Thompson R, Bygbjerg IC, Rønn AM, 2003. Prediction of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: a comparative study between sites of differing endemicity. Am J Trop Med Hyg 69: 601-606.
    • (2003) Am J Trop Med Hyg , vol.69 , pp. 601-606
    • Alifrangis, M.1    Enosse, S.2    Khalil, I.F.3    Tarimo, D.S.4    Lemnge, M.M.5    Thompson, R.6    Bygbjerg, I.C.7    Rønn, A.M.8
  • 34
    • 0346216115 scopus 로고    scopus 로고
    • Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan
    • Anderson TJ, Nair S, Jacobzone C, Zavai A, Balkan S, 2003. Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan. Trop Med Int Health 8: 1068-1073.
    • (2003) Trop Med Int Health , vol.8 , pp. 1068-1073
    • Anderson, T.J.1    Nair, S.2    Jacobzone, C.3    Zavai, A.4    Balkan, S.5
  • 35
    • 77955601121 scopus 로고    scopus 로고
    • National Malaria Control Program, Khartoum, Sudan: Federal Ministry of Health
    • National Malaria Control Program, 2004. The National Protocol for Treatment of Malaria. Khartoum, Sudan: Federal Ministry of Health.
    • (2004) The National Protocol for Treatment of Malaria
  • 36
    • 3342910274 scopus 로고    scopus 로고
    • Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
    • Alker AP. Mwapasa V, Meshnick SR, 2004. Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum. Antimicrob Agents Chemother 48: 2924-2929.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2924-2929
    • Alker, A.P.1    Mwapasa, V.2    Meshnick, S.R.3
  • 37
    • 10044276938 scopus 로고    scopus 로고
    • Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay
    • Wilson PE, Kazadi W, Kamwendo DD, Mwapasa V, Purfield A, Meshnick SR, 2005. Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay. Acta Trop 93: 97-106.
    • (2005) Acta Trop , vol.93 , pp. 97-106
    • Wilson, P.E.1    Kazadi, W.2    Kamwendo, D.D.3    Mwapasa, V.4    Purfield, A.5    Meshnick, S.R.6
  • 38
    • 0034732666 scopus 로고    scopus 로고
    • The tyrosine-86 allele of the pfmdrI gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
    • Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC, 2000. The tyrosine-86 allele of the pfmdrI gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 108: 13-23.
    • (2000) Mol Biochem Parasitol , vol.108 , pp. 13-23
    • Duraisingh, M.T.1    Jones, P.2    Sambou, I.3    Von Seidlein, L.4    Pinder, M.5    Warhurst, D.C.6
  • 39
    • 0032079104 scopus 로고    scopus 로고
    • Plasmodium falciparum: Detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion
    • Duraisingh MT, Curtis J, Warhurst DC, 1998. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol 89: 1-8.
    • (1998) Exp Parasitol , vol.89 , pp. 1-8
    • Duraisingh, M.T.1    Curtis, J.2    Warhurst, D.C.3
  • 40
    • 40849086202 scopus 로고    scopus 로고
    • Detection of novel point mutations in the Plasmodium falciparum ATPase6 candidate gene for resistance to artemisinins
    • Menegon M, Sannella AR, Majori G, Severini C, 2008. Detection of novel point mutations in the Plasmodium falciparum ATPase6 candidate gene for resistance to artemisinins. Parasitol Int 57: 233-235.
    • (2008) Parasitol Int , vol.57 , pp. 233-235
    • Menegon, M.1    Sannella, A.R.2    Majori, G.3    Severini, C.4
  • 43
    • 33845270952 scopus 로고    scopus 로고
    • Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum
    • Osman ME, Mockenhaupt FP, Bienzle U, Elbashir MI, Giha HA, 2007. Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum. Infect Genet Evol 7: 52-59.
    • (2007) Infect Genet Evol , vol.7 , pp. 52-59
    • Osman, M.E.1    Mockenhaupt, F.P.2    Bienzle, U.3    Elbashir, M.I.4    Giha, H.A.5
  • 44
    • 0035873715 scopus 로고    scopus 로고
    • High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdrl
    • Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdrl. J Infect Dis 183: 1535-1538.
    • (2001) J Infect Dis , vol.183 , pp. 1535-1538
    • Babiker, H.A.1    Pringle, S.J.2    Abdel-Muhsin, A.3    Mackinnon, M.4    Hunt, P.5    Walliker, D.6
  • 46
    • 0344838487 scopus 로고    scopus 로고
    • Malaria drug-sensitivity testing: New assays, new perspectives
    • Noedl H, Wongsrichanalai C, Wernsdorfer WH, 2003. Malaria drug-sensitivity testing: new assays, new perspectives. Trends Parasitol 19: 175-181.
    • (2003) Trends Parasitol , vol.19 , pp. 175-181
    • Noedl, H.1    Wongsrichanalai, C.2    Wernsdorfer, W.H.3
  • 47
    • 0038018106 scopus 로고    scopus 로고
    • Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal
    • Daily JP, Roberts C, Thomas SM. Ndir O, Dieng T, Mboup S, Wirth DF, 2003. Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal. Parasitology 126: 401-405.
    • (2003) Parasitology , vol.126 , pp. 401-405
    • Daily, J.P.1    Roberts, C.2    Thomas, S.M.3    Ndir, O.4    Dieng, T.5    Mboup, S.6    Wirth, D.F.7
  • 48
    • 0036562621 scopus 로고    scopus 로고
    • In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdrI polymorphisms in Plasmodium falciparum isolates from Senegal
    • Thomas SM, Ndir O, Dieng T, Mboup S, Wypij D, Maguire JH, Wirth DF. 2002. In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdrI polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg 66: 474-480.
    • (2002) Am J Trop Med Hyg , vol.66 , pp. 474-480
    • Thomas, S.M.1    Ndir, O.2    Dieng, T.3    Mboup, S.4    Wypij, D.5    Maguire, J.H.6    Wirth, D.F.7
  • 49
    • 0036467783 scopus 로고    scopus 로고
    • Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1
    • Chen N, Russell B, Fowler E, Peters J, Cheng Q, 2002. Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1. J Infect Dis 185: 405-407.
    • (2002) J Infect Dis , vol.185 , pp. 405-407
    • Chen, N.1    Russell, B.2    Fowler, E.3    Peters, J.4    Cheng, Q.5
  • 50
    • 7944224830 scopus 로고    scopus 로고
    • Withdrawing antimalarial drugs: Impact on parasite resistance and implications for malaria treatment policies
    • Laufer MK, Plowe CV, 2004. Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies. Drug Resist Updat 7: 279-288.
    • (2004) Drug Resist Updat , vol.7 , pp. 279-288
    • Laufer, M.K.1    Plowe, C.V.2
  • 52
    • 67650327631 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene
    • Tahar R, Ringwald P, Basco LK. 2009. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am J Trop Med Hyg 81: 13-18.
    • (2009) Am J Trop Med Hyg , vol.81 , pp. 13-18
    • Tahar, R.1    Ringwald, P.2    Basco, L.K.3
  • 54
    • 36049010956 scopus 로고    scopus 로고
    • The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
    • A-Elbasit IE, Alifrangis M, Khalil IF. Bygbjerg IC, Masuadi EM, Elbashir MI, Giha HA, 2007. The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics. Malar J 6: 108.
    • (2007) Malar J , vol.6 , pp. 108
    • A-Elbasit, I.E.1    Alifrangis, M.2    Khalil, I.F.3    Bygbjerg, I.C.4    Masuadi, E.M.5    Elbashir, M.I.6    Giha, H.A.7
  • 56
    • 0034777332 scopus 로고    scopus 로고
    • Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana
    • Mockenhaupt FP, Eggelte TA, Till H, Bienzle U, 2001. Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana. Trop Med Int Health 6: 749-755.
    • (2001) Trop Med Int Health , vol.6 , pp. 749-755
    • Mockenhaupt, F.P.1    Eggelte, T.A.2    Till, H.3    Bienzle, U.4
  • 57
    • 0035315868 scopus 로고    scopus 로고
    • Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone
    • Toteja R, Nair L, Bhasin V, 2001. Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone. Mem Inst Oswaldo Cruz 96: 427-433.
    • (2001) Mem Inst Oswaldo Cruz , vol.96 , pp. 427-433
    • Toteja, R.1    Nair, L.2    Bhasin, V.3


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