Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein

World Journal of Gastroenterology

Volumn 12, Issue 13, 2006, Pages 2024-2030

  Naito, Yuji ^a   Katada, Kazuhiko ^b   Takagi, Tomohisa ^a   Tsuboi, Hisato ^b   Kuroda, Masaaki ^b   Handa, Osamu ^a   Kokura, Satoshi ^a   Yoshida, Norimasa ^b   Ichikawa, Hiroshi ^c   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Endothelium; Intestine; Ischemia reperfusion injury; Nitric oxide synthase; Rat; Rosuvastatin

Indexed keywords

CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEMOGLOBIN; MESSENGER RNA; MYELOPEROXIDASE; ROSUVASTATIN; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERY CLAMP; ARTICLE; CELIAC ARTERY STENOSIS; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; ENZYME ACTIVITY; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; INTESTINE INJURY; INTESTINE ISCHEMIA; MALE; NONHUMAN; PROTECTION; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION; WESTERN BLOTTING;

EID: 33646465740     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i13.2024     Document Type: Article

References (30)

1. Cappell MS. Intestinal (mesenteric) vasculopathy. II. Ischemic colitis and chronic mesenteric ischemia. Gastroenterol Clin North Am 1998; 27: 827-860
2. Homer-Vanniasinkam S, Crinnion JN, Gough MJ. Post-ischaemic organ dysfunction: a review. Eur J Vasc Endovasc Surg 1997; 14: 195-203
3. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN. Role of neutrophils in ischemia-reperfusion induced microvascular injury. Am J Physiol 1987; 253: H699-H703
4. Palluy O, Morliere L, Gris JC, Bonne C, Modat G. Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radic Biol Med 1992; 13: 21-30
5. Yoshida N, Granger DN, Anderson DC, Rothlein R, Lane C, Kvietys PR. Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. Am J Physiol 1992; 262: H1891-H1898
6. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation 2000; 101: 207-213
7. Oda H, Keane WF. Recent advances in statins and the kidney. Kidney Int Suppl 1999; 71: S2-S5
8. Endres M, Laufs U. Effects of statins on endothelium and signaling mechanisms. Stroke 2004; 35: 2708-2711
9. Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001; 7: 687-692
10. Ikeda Y, Young LH, Lefer AM. Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats. J Cardiovasc Pharmacol 2003; 41: 649-656
11. Bulhak A, Sjoquist PO, Pernow J. Rosuvastatin protects the myocardium. against ischaemia-reperfusion injury via inhibition of GGPP synthesis. Cardiovasc J S Afr 2004; 15: S11
12. Weinberg EO, Scherrer-Crosbie M, Picard MH, Nasseri BA, MacGillivray C, Gannon J, Lian Q, Bloch KD, Lee RT. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am J Physiol Heart Circ Physiol 2005; 288: H1802-H1809
13. Bulhak AA, Gourine AV, Gonon AT, Sjoquist PO, Valen G, Pernow J. Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level. Acta Physiol Scand 2005; 183; 151-159
14. Di Napoli P, Taccardi AA, Grilli A, De Lutiis MA, Barsotti A, Felaco M, De Caterina R. Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc Res 2005; 66: 462-471
15. Naito Y, Takagi T, Uchiyama K, Handa O, Tomatsuri N, Imamoto E, Kokura S, Ichikawa H, Yoshida N, Yoshikawa T. Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-gamma ligand, pioglitazone, in rats. Redox Rep 2002; 7: 294-299
16. Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y, Katada K, Uchiyama K, Kokura S, Yoshida N, Okanoue T, Yoshikawa T. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide 2004; 10: 170-177
17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358
18. Grisham MB, Hernandez LA, Granger DN. Xanthine oxidase and neutrophil infiltration in intestinal ischemia . Am J Physiol 1986; 251: G567-G574
19. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK. Stroke protection by 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors mediated by endothelial. nitric oxide synthase. Proc Natl Acad Sci U S A 1998; 95: 8880-8885
20. Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K, Klein HH, Dominiak P, Richardt G. Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol 2004; 44: 348-355
21. Granger DN. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 1988; 255: H1269-H1275
22. Kurtel H, Fujimoto K, Zimmerman BJ, Granger DN, Tso P. Ischemia-reperfusion-induced mucosal dysfunction: role of neutrophils. Am J Physiol 1991; 261: G490-G496
23. Slocum MM, Granger DN. Early mucosal and microvascular changes in feline intestinal transplants. Gastroenterology 1993; 105: 1761-1768
24. Yagihashi A, Tsuruma T, Tarumi K, Kameshima T, Yajima T, Yanai Y, Watanabe N, Hirata K. Prevention of small intestinal ischemia-reperfusion injury in rat by anti-cytokine-induced neutrophil chemoattractant monoclonal antibody. J Surg Res 1998; 78: 92-96
25. Honjo M, Tanihara H, Nishijima K, Kiryu J, Honda Y, Yue BY, Sawamura T. Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina. Arch Ophthalmol 2002; 120: 1707-1713
26. Naidu BV, Woolley SM, Farivar AS, Thomas R, Fraga C, Mulligan MS. Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion. J Thorac Cardiovasc Surg 2003; 126: 482-489
27. Morikawa S, Takabe W, Mataki C, Kanke T, Itoh T, Wada Y, Izumi A, Saito Y, Hamakubo T, Kodama T. The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells. J Atheroscler Thromb 2002; 9: 178-183
28. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998; 97: 1129-1135
29. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A 1991; 88: 4651-4655
30. Lefer AM. Nitric oxide: nature's naturally occurring leukocyte inhibitor. Circulation 1997; 95: 553-554