Inhibition of nitric oxide synthesis accelerates the recovery of polysynaptic reflex potentials after transient spinal cord ischemia in cats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 355, Issue 4, 1997, Pages 447-451

  Nemoto, Tetsuharu ^a   Sekikawa, Toshihiko ^a   Suzuki, Toshio ^a   Moriya, Hideshige ^a   Nakaya, Haruaki ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Ischemia; N(G) Monomethyl L arginine; Nitric oxide; Nitroprusside; Reflex potential; Spinal cord

Indexed keywords

ARGININE; DEXTRO ARGININE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM;

ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; POLYSYNAPTIC REFLEX; SPINAL CORD ISCHEMIA;

ANIMALS; CATS; DISEASE MODELS, ANIMAL; FEMALE; ISCHEMIA; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; REFLEX; SPINAL CORD DISEASES; SYNAPTIC TRANSMISSION;

EID: 0030895984     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00004967     Document Type: Article

References (24)

1. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
2. Benveniste H, Drejer J, Shoushoe A, Diemer NH (1984) Elevation of the extracellular concentrations of glutamate and aspartate in the rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369-1374
3. Blough NV, Zafiriou OC (1985) Reaction of superoxide with nitric oxide to form peroxynitrite in alkaline aqueous solution. Inorg Chem 24:3502-3504
4. Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87:682-685
5. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770
6. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH (1991) Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7:615-624
7. Dalkara T, Moskowitz MA (1994) The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol 4:49-57
8. Dawson TM, Dawson VL, Snyder SH (1992) A novel neuronal messenger molecule in brain: The free radical, nitric oxide. Ann Neurol 32:297-311
9. Kuluz JW, Prado RJ, Dietrich WD, Schleien CL, Watson BD (1993) The effect of nitric oxide synthase inhibtion on infarct volume after reversible focal cerebral ischemia in conscious rats. Stroke 24:2023-2029
10. Long JB, Rigamonti DD, Oleshansky MA, Wingfield CP, Martinez-Arizala A (1994) Dynorphin A-induced rat spinal cord injury: evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury. J Pharmacol Exp Ther 269:358-366
11. Malinski T, Bailey F, Zhang ZG, Chopp M (1993) Nitric oxide measured by a porphyric microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13:355-358
12. Manzoni O, Prezeau L, Marin P, Deshager S, Bockaert J, Fagni L (1992) Nitric oxide-induced blockade of NMDA receptors. Neuron 8:653-662
13. Moncada S, Higgs EA (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012
14. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142
15. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T (1994) L-Arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25:429-435
16. Nishimura H, Rosenblum WI, Nelson GH, Boynton S (1991) Agents that modify EDRF formation alter antiplatelet properties of brain arteriolar endothelium in vivo. Am J Physiol 261:H15-H21
17. Rees DD, Palmer RMJ, Moncada S (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86:3375-3378
18. Schmidt HHHW, Pollock JS, Nakane M, Gorsky LD, Förstermann U, Murad F (1991) Purification of a soluble isoform of guanylyl cyclase-activating factor synthase. Proc Natl Acad Sci USA 88:365-369
19. Snyder SH, Bredt DS (1991) Nitric oxide as a neuronal messenger. Trends Pharmacol Sci 12:125-128
20. Suzuki T, Sekikawa T, Nemoto T, Moriya H, Nakaya H (1995) Effects of nicorandil on the recovery of reflex potentials after spinal cord ischaemia in cats. Br J Pharmacol 116:1815-1820
21. Terenghi G, Riveros-Moreno V, Hudson LD, Ibrahim NBN, Polak JM (1993) Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat. J Neurol Sci 118:34-37
22. Valtschanoff JG, Weinberg RJ, Rustioni A (1992) NADPH diaphorase in the spinal cord of rats. J Comp Neurol 321:209-222
23. G-nitro-L-arginine enhances neuronal death following transient forebrain ishcemia in gerbils. Neurosci Lett 146:139-142
24. Yamamoto S, Golanov EV, Berger SB, Reis DJ (1992) Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab 12:717-726