Fast- or slow-inactivated state preference of Na+ channel inhibitors: A simulation and experimental study

PLoS Computational Biology

Volumn 6, Issue 6, 2010, Pages 1-13

  Karoly, Robert ^a   Lenkey, Nora ^a   Juhasz, Andras O ^a   Sylvester Vizi, E ^a   Mike, Arpad ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETICS; SODIUM;

CHANNEL INHIBITOR; CONFORMATIONAL STATE; DRUG TARGETS; INACTIVATED STATE; INACTIVATION OF SODIUM CHANNELS; INHIBITORY MECHANISM; LOCAL ANAESTHETIC; NA+ CHANNEL; SODIUM CHANNEL; THERAPEUTIC APPLICATION;

ELECTROPHYSIOLOGY;

CARBAMAZEPINE; DESIPRAMINE; FLUOXETINE; LIDOCAINE; PHENYTOIN; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ELECTRIC POTENTIAL; EMBRYO; EXPERIMENTAL STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NONHUMAN; SIMULATION; STEADY STATE; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; COMPUTER SIMULATION; ELECTROPHYSIOLOGY; MONTE CARLO METHOD; PATCH CLAMP; PHYSIOLOGY; TIME;

ANIMALS; CELLS, CULTURED; COMPUTER SIMULATION; ELECTROPHYSIOLOGY; HUMANS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PATCH-CLAMP TECHNIQUES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TIME FACTORS;

EID: 77955503910     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000818     Document Type: Article

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