Carbamazepine inhibition of neuronal Na+ currents: Quantitative distinction from phenytoin and possible therapeutic implications

Molecular Pharmacology

Volumn 51, Issue 6, 1997, Pages 1077-1083

  Kuo, Chung Chin ^a,b   Chen, Ren Shiang ^a   Lu, Lu ^b   Chen, Rong Chi ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c EN CHU KONG HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHENYTOIN; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION CONSTANT; DRUG BINDING; EPILEPSY; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SODIUM CURRENT;

EID: 0030949912     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.6.1077     Document Type: Article

References (23)

1. McLean, M. J., and R. L. McDonald. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. J. Pharmacol. Exp. Ther. 227: 779-789 (1983).
2. McLean, M. J., and R. L. McDonald. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J. Pharmacol. Exp. Ther. 238:727-738 (1986).
3. Adler, E., Y. Yaari, G. David, and M. E. Selzer. Frequency-dependent action of phenytoin on lamprey spinal axons. Brain Res. 362:271-280 (1986).
4. Butterworth, J. F., and G. R. Strichartz. Molecular mechanisms of local anesthesia: a review. Anesthesiology 72:711-734 (1990).
5. Lipicky, R. J., D. L. Gilbert, and I. M. Stillman. Diphenylhydantoin inhibition of sodium conductance in squid giant axon. Proc. Natl. Acad. Sci. USA 69:1758-1760 (1972).
6. Matsuki, N., F. N. Quandt, R. E. Ten Eick, and J. Z. Yeh. Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells. J. Pharmacol. Exp. Ther. 228:523-530 (1984).
7. Willow, M., T. Gonoi, and W. A. Catterall. Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol. Pharmacol. 27: 549-558 (1985).
8. Schwarz, J. R., and G. Grigat. Phenytoin and carbamazepine: potential and frequency-dependent block of Na currents in mammalian myelinated nerve fibers. Epilepsia 30:286-294 (1989).
9. Hille, B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69:497-515 (1977).
10. Hille, B. Ionic channels of excitable membranes. Sinauer Associates, Sunderland, MA, 408-411 (1993).
11. Lang, D. G., C. M. Wang, and B. R. Cooper. Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J. Pharmacol. Exp. Ther. 266:829-835 (1993).
12. + channels must deactivate to recover from inactivation. Neuron 12:819-829 (1994).
13. Kuo, C.-C., and B. P. Bean. Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Mol. Pharmacol. 46:716-725 (1994).
14. Bean, B. P. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc. Natl. Acad. Sci. USA 81:6386-6392 (1984).
15. Bean, B. P., C. J. Cohen, and R. W. Tsien. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81:613-642 (1983).
16. Matsumoto, H., and C. Ajmone-Marsan. Cortical cellular phenomena in experimental epilepsy: interictal manifestations. Exp. Neurol. 9:286-304 (1964).
17. Matsumoto, H., and C. Ajmone-Marsan. Cortical cellular phenomena in experimental epilepsy: ictal manifestations. Exp. Neurol. 9:305-326 (1964).
18. Dichter, M. A., and G. F. Ayala. Cellular mechanisms of epilepsy: a status report. Science (Washington D. C.) 237:157-237 (1987).
19. Lothman, E. W., and R. C. Collins. Seizures and epilepsy, in Neurobiology of Disease. (A. L. Pearlman and R. C. Collins, eds.). 4th Ed. Oxford University Press, New York, 276-298 (1990).
20. Sherwin, A. L., A. A. Eisen, and C. D. Sokolowski. Anticonvulsant drugs in human epileptogenic brain. Arch. Neurol. 29:73-77 (1973).
21. Richens, A. Clinical pharmacokinetics of phenytoin. Clin. Pharmacokinet. 4:153-169 (1979).
22. Johannessen, S. I., and R. E. Strandjord. Concentration of carbamazepine (Tegretol) in serum and in cerebrospinal fluid in patients with epilepsy. Epilepsia 14:373-379 (1973).
23. Bourgeois, B. F. D. Pharmacokinetics and pharmacodynamics in clinical practice, in The Treatment of Epilepsy (E. Wyllie, ed.). Lea and Febinger, Philadelphia, 726-734 (1993).