The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel

Journal of General Physiology

Volumn 134, Issue 2, 2009, Pages 95-113

  Yang, Ya Chin ^a   Hsieh, Jui Yi ^b   Kuo, Chung Chin ^b,c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTICONVULSIVE AGENT; ARGININE; ASPARTIC ACID; CADMIUM; CARBAMAZEPINE; CYSTEINE; DRUG RECEPTOR; GLUTAMIC ACID; GLYCINE; LAMOTRIGINE; LOCAL ANESTHETIC AGENT; LYSINE; METHANETHIOSULFONATE; PHENYLALANINE; PHENYTOIN; POTASSIUM ION; REAGENT; SODIUM CHANNEL; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING; MEMBRANE PERMEABILITY; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

ANIMALS; ANTICONVULSANTS; BINDING SITES; CARBAMAZEPINE; FEMALE; ION CHANNEL GATING; MODELS, BIOLOGICAL; PHENYTOIN; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TRIAZINES; XENOPUS LAEVIS;

EID: 67749106186     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200810158     Document Type: Article

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