Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential

Nature Biotechnology

Volumn 24, Issue 4, 2006, Pages 439-446

  Huang, Chien Jung ^a   Harootunian, Alec ^a   Maher, Michael P ^a   Quan, Catherine ^a   Raj, Christopher D ^a   McCormack, Ken ^a   Numann, Randal ^a   Negulescu, Paul A ^a   González, Jesús E ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRIC FIELDS; ELECTROOPTICAL EFFECTS; FLUORESCENCE; ION EXCHANGE MEMBRANES; VOLTAGE CONTROL;

CHANNEL ACTIVITY; ELECTRICAL FIELD STIMULATION; MEMBRANE POTENTIAL; PAROXETINE; VOLTAGE-GATED SODIUM-CHANNEL;

ELECTROPHYSIOLOGY;

AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CARBAMAZEPINE; DESIPRAMINE; DOXEPIN; ETIDOCAINE; FLUORESCENT DYE; FLUOXETINE; FLUVOXAMINE; LAMOTRIGINE; LIDOCAINE; MEXILETINE; MIRTAZAPINE; NEFAZODONE; PAROXETINE; PROTRIPTYLINE; RILUZOLE; SERTRALINE; SIBUTRAMINE; SODIUM CHANNEL BLOCKING AGENT; TETRACAINE; TETRODOTOXIN; TRIMIPRAMINE; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; AUTOMATION; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ELECTROSTIMULATION; EMBRYO; FLUORESCENCE; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; VOLTAGE CLAMP;

CELLS, CULTURED; DRUG DESIGN; ELECTRIC STIMULATION; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; NEURONS; PATCH-CLAMP TECHNIQUES; PHARMACEUTICAL PREPARATIONS; SODIUM CHANNELS;

EID: 33645733252     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1194     Document Type: Article

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