Immunopathologies linked to integrin signalling

Seminars in Immunopathology

Volumn 32, Issue 2, 2010, Pages 173-182

  Wang, Hongyan ^a,b,c   Lim, Daina ^a   Rudd, Christopher E ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Integrins; Kindlin 3; LAD; LFA 1; RapL; SKAP1; SLP 76

Indexed keywords

ADAPTOR PROTEIN; ALPHA INTEGRIN; BETA INTEGRIN; BETA2 INTEGRIN; BINDING PROTEIN; FYN T BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; INTERLEUKIN 6; KINDLIN 1; KINDLIN 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN KINASE ZAP 70; PROTEIN VAV1; RAP1 PROTEIN; REGULATOR OF ADHESION AND CELL POLARISATION ENRICHED IN LYMPHOID TISSUE PROTEIN; REGULATOR PROTEIN; T LYMPHOCYTE RECEPTOR; TALIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; DRUG RESEARCH; GENE MUTATION; HUMAN; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; LEUKOCYTE ADHESION DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CELL ADHESION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; CELL ADHESION; HUMANS; IMMUNE SYSTEM DISEASES; INTEGRINS; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION;

EID: 77955483193     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-010-0202-3     Document Type: Review

References (99)

1. DP Andrew JP Spellberg H Takimoto R Schmits TW Mak MM Zukowski 1998 Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice Eur J Immunol 28 1959 1969 10.1002/(SICI)1521-4141(199806)28:06<1959::AID- IMMU1959>3.0.CO;2-4 1:CAS:528:DyaK1cXjsleitrk%3D 9645378
2. RG Baker CJ Hsu D Lee MS Jordan JS Maltzman DA Hammer T Baumgart GA Koretzky 2009 The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells Mol Cell Biol 29 5578 5589 10.1128/MCB.00283-09 1:CAS:528:DC%2BD1MXhtlWjur%2FN 19667077
3. EK Barber JD Dasgupta SF Schlossman JM Trevillyan CE Rudd 1989 The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex Proc Natl Acad Sci U S A 86 3277 3281 10.1073/pnas.86.9.3277 1:CAS:528:DyaL1MXktVGmsrg%3D 2470098
4. N Bezman GA Koretzky 2007 Compartmentalization of ITAM and integrin signaling by adapter molecules Immunol Rev 218 9 28 10.1111/j.1600-065X.2007. 00541.x 1:CAS:528:DC%2BD2sXhtVSiu7%2FP 17624941
5. M Bunting ES Harris TM McIntyre SM Prescott GA Zimmerman 2002 Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving 2 integrins and selectin ligands Curr Opin Hematol 9 30 35 10.1097/00062752- 200201000-00006 11753075
6. EC Butcher LJ Picker 1996 Lymphocyte homing and homeostasis Science 272 60 66 10.1126/science.272.5258.60 1:CAS:528:DyaK28XitVKkt70%3D 8600538
7. DA Calderwood B Yan JM de Pereda BG Alvarez Y Fujioka RC Liddington MH Ginsberg 2002 The phosphotyrosine binding-like domain of talin activates integrins J Biol Chem 277 21749 21758 10.1074/jbc.M111996200 1:CAS:528:DC%2BD38Xksl2js78%3D 11932255
8. DA Calderwood 2004 Integrin activation J Cell Sci 117 657 666 10.1242/jcs.01014 1:CAS:528:DC%2BD2cXhvVOntrc%3D 14754902
9. CV Carman TA Springer 2003 Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol 15 547 556 10.1016/j.ceb.2003.08.003 1:CAS:528:DC%2BD3sXnslSqsLc%3D 14519389
10. RA Clemens SA Newbrough EY Chung S Gheith AL Singer GA Koretzky EJ Peterson 2004 PRAM-1 is required for optimal integrin-dependent neutrophil function Mol Cell Biol 24 10923 10932 10.1128/MCB.24.24.10923-10932.2004 1:CAS:528:DC%2BD2cXhtFSgsr%2FJ 15572693
11. AJ da Silva Z Li C de Vera E Canto P Findell CE Rudd 1997 Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production Proc Natl Acad Sci U S A 94 7493 7498 10.1073/pnas.94.14.7493 9207119
12. AJ da Silva JM Rosenfield I Mueller A Bouton H Hirai CE Rudd 1997 Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells J Immunol 158 2007 2016 9036943
13. JM de Pereda KL Wegener E Santelli N Bate MH Ginsberg DR Critchley ID Campbell RC Liddington 2005 Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions J Biol Chem 280 8381 8386 10.1074/jbc.M413180200 15623515
14. M Duchniewicz T Zemojtel M Kolanczyk S Grossmann JS Scheele FJ Zwartkruis 2006 Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion Mol Cell Biol 26 643 653 10.1128/MCB.26.2.643-653.2006 1:CAS:528:DC%2BD28XhtVOht74%3D 16382154
15. JS Duke-Cohen H Kang H Liu CE Rudd 2006 Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein J Biol Chem 281 13743 13750 10.1074/jbc.M508774200
16. JA Epler R Liu H Chung NC Ottoson Y Shimizu 2000 Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity J Immunol 165 4941 4949 1:CAS:528:DC%2BD3cXnvVOns7g%3D 11046020
17. A Etzioni M Frydman S Pollack I Avidor ML Phillips JC Paulson R Gershoni-Baruch 1992 Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency N Engl J Med 327 1789 1792 1:STN:280: DyaK3s%2FmtlWgsQ%3D%3D 1279426
18. MA Gakidis X Cullere T Olson JL Wilsbacher B Zhang SL Moores K Ley W Swat T Mayadas JS Brugge 2004 Vav GEFs are required for beta2 integrin-dependent functions of neutrophils J Cell Biol 166 273 282 10.1083/jcb.200404166 1:CAS:528:DC%2BD2cXlvFKqsrk%3D 15249579
19. L Geng S Pfister SK Kraeft CE Rudd 2001 Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain Proc Natl Acad Sci U S A 98 11527 11532 10.1073/pnas.191378198 1:CAS:528:DC%2BD3MXnt12jsr0%3D 11553777
20. E Georges-Labouesse N Messaddeq G Yehia L Cadalbert A Dierich M Le Meur 1996 Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice Nat Genet 13 370 373 10.1038/ng0796-370 1:STN:280: DyaK283lvFGksg%3D%3D 8673141
21. H Ghandour X Cullere A Alvarez FW Luscinskas TN Mayadas 2007 Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion Blood 110 3682 3690 10.1182/blood-2007-03-077628 1:CAS:528:DC%2BD2sXhtlarurvO 17702895
22. E Goksoy YQ Ma X Wang X Kong D Perera EF Plow J Qin 2008 Structural basis for the autoinhibition of talin in regulating integrin activation Mol Cell 31 124 133 10.1016/j.molcel.2008.06.011 1:CAS:528:DC%2BD1cXovFWnsrY%3D 18614051
23. DB Graham CM Robertson J Bautista F Mascarenhas MJ Diacovo V Montgrain SK Lam V Cremasco WM Dunne R Faccio CM Coopersmith W Swat 2007 Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice J Clin Invest 117 3445 3452 10.1172/JCI32729 1:CAS:528: DC%2BD2sXht12is77I 17932569
24. EK Griffiths C Krawczyk YY Kong M Raab SJ Hyduk D Bouchard VS Chan I Kozieradzki AJ Oliveira-Dos-Santos A Wakeham PS Ohashi MI Cybulsky CE Rudd JM Penninger 2001 Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap Science 293 2260 2263 10.1126/science.1063397 1:CAS:528:DC%2BD3MXntFCru7k%3D 11567140
25. J Han CJ Lim N Watanabe A Soriani B Ratnikov DA Calderwood W Puzon-McLaughlin EM Lafuente VA Boussiotis SJ Shattil MH Ginsberg 2006 Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3 Curr Biol 16 1796 1806 10.1016/j.cub.2006.08.035 1:CAS:528:DC%2BD28Xps1Onsro%3D 16979556
26. DS Harburger DA Calderwood 2009 Integrin signalling at a glance J Cell Sci 122 159 163 10.1242/jcs.018093 1:CAS:528:DC%2BD1MXit1GqtLw%3D 19118207
27. N Hogg M Laschinger K Giles A McDowall 2003 T-cell integrins: more than just sticking points J Cell Sci 116 4695 4705 10.1242/jcs.00876 1:CAS:528:DC%2BD3sXhtVShtLbP 14600256
28. RO Hynes 2002 Integrins: bidirectional, allosteric signaling machines Cell 110 673 687 10.1016/S0092-8674(02)00971-6 1:CAS:528:DC%2BD38XnsFKis70%3D 12297042
29. EK Jo H Wang CE Rudd 2005 An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R J Exp Med 201 1733 1739 10.1084/jem.20042577 1:CAS:528:DC%2BD2MXltFagu7o%3D 15939789
30. BA Judd PS Myung L Leng A Obergfell WS Pear SJ Shattil GA Koretzky 2000 Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors Proc Natl Acad Sci U S A 97 12056 12061 10.1073/pnas.97.22.12056 1:CAS:528:DC%2BD3cXnvVSgt7g%3D 11050236
31. BA Judd PS Myung A Obergfell EE Myers AM Cheng SP Watson WS Pear D Allman SJ Shattil GA Koretzky 2002 Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling J Exp Med 195 705 717 10.1084/jem.20011583 1:CAS:528:DC%2BD38Xitl2gt7g%3D 11901197
32. S Kandula C Abraham 2004 LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo J Immunol 173 4443 4451 1:CAS:528:DC%2BD2cXnslWmtro%3D 15383575
33. H Kang C Freund JS Duke-Cohan A Musacchio G Wagner CE Rudd 2000 SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55 EMBO J 19 2889 2899 10.1093/emboj/19.12.2889 1:CAS:528:DC%2BD3cXmtFCqsrs%3D 10856234
34. K Katagiri M Hattori N Minato T Kinashi 2002 Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Mol Cell Biol 22 1001 1015 10.1128/MCB.22.4.1001-1015.2002 1:CAS:528:DC%2BD38XovVWkuw%3D%3D 11809793
35. K Katagiri A Maeda M Shimonaka T Kinashi 2003 RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 Nat Immunol 4 741 748 10.1038/ni950 1:CAS:528:DC%2BD3sXlvVajtbY%3D 12845325
36. K Katagiri N Ohnishi K Kabashima T Iyoda N Takeda Y Shinkai K Inaba T Kinashi 2004 Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking Nat Immunol 5 1045 1051 10.1038/ni1111 1:CAS:528:DC%2BD2cXnvFCgsrs%3D 15361866
37. JS Kern C Herz E Haan D Moore S Nottelmann T von Lilien P Greiner A Schmitt-Graeff OG Opitz L Bruckner-Tuderman C Has 2007 Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms J Pathol 213 462 470 10.1002/path.2253 1:CAS:528:DC%2BD1cXhvFKiuw%3D%3D 17955455
38. M Kim CV Carman TA Springer 2003 Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins Science 301 1720 1725 10.1126/science.1084174 1:CAS:528:DC%2BD3sXntlSgtrc%3D 14500982
39. T Kinashi M Aker M Sokolovsky-Eisenberg V Grabovsky C Tanaka R Shamri S Feigelson A Etzioni R Alon 2003 LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds Blood 103 1033 1036 10.1182/blood-2003-07-2499 14551137
40. T Kinashi 2005 Intracellular signalling controlling integrin activation in lymphocytes Nat Rev Immunol 5 546 559 10.1038/nri1646 1:CAS:528: DC%2BD2MXlsl2isbg%3D 15965491
41. S Kliche D Breitling M Togni R Pusch K Heuer X Wang C Freund A Kasirer-Friede G Menasche GA Koretzky B Schraven 2006 The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1 Mol Cell Biol 26 7130 7144 10.1128/MCB.00331-06 1:CAS:528:DC%2BD28XhtVCltbbP 16980616
42. C Krawczyk A Oliveira-dos-Santos T Sasaki E Griffiths PS Ohashi S Snapper F Alt JM Penninger 2002 Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells Immunity 16 331 343 10.1016/S1074-7613(02)00291-1 1:CAS:528:DC%2BD38Xis1WmsLg%3D 11911819
43. JA Kreidberg MJ Donovan SL Goldstein H Rennke K Shepherd RC Jones R Jaenisch 1996 Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis Development 122 3537 3547 1:CAS:528:DyaK28XntlSktbo%3D 8951069
44. JE Lai-Cheong S Ussar K Arita IR Hart JA McGrath 2007 Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome J Invest Dermatol 128 2156 2165 10.1038/jid.2008.58
45. D Law L Nannizzi-Alaimo K Ministri PE Hughes J Forsyth M Turner SJ Shattil MH Ginsberg VL Tybulewicz DR Phillips 1999 Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets Blood 93 2645 2652 1:CAS:528:DyaK1MXisVGktL0%3D 10194444
46. M Lebwohl SK Tyring TK Hamilton D Toth S Glazer NH Tawfik P Walicke W Dummer X Wang MR Garovoy D Pariser ES Group 2003 A novel targeted T-cell modulator, efalizumab, for plaque psoriasis N Engl J Med 349 2004 2013 10.1056/NEJMoa030002 1:CAS:528:DC%2BD3sXptFGnsb8%3D 14627785
47. HS Lee CJ Lim W Puzon-McLaughlin SJ Shattil MH Ginsberg 2009 RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences J Biol Chem 284 5119 5127 10.1074/jbc.M807117200 1:CAS:528:DC%2BD1MXhvVSntro%3D 19098287
48. KR Legate E Montañez O Kudlacek R Fässler 2006 ILK, PINCH and parvin: the tIPP of integrin signalling Nat Rev Mol Cell Biol 7 20 31 10.1038/nrm1789 1:CAS:528:DC%2BD28XlsFSmsQ%3D%3D 16493410
49. KR Legate R Fässler 2009 Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails J Cell Sci 122 187 198 10.1242/jcs.041624 1:CAS:528:DC%2BD1MXit1GqtLg%3D 19118211
50. J Liu H Kang M Raab AJ da Silva SK Kraeft CE Rudd 1998 FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells Proc Natl Acad Sci U S A 95 8779 8784 10.1073/pnas.95.15.8779 1:CAS:528:DyaK1cXkvFalsbs%3D 9671755
51. K Lühn MK Wild M Eckhardt R Gerardy-Schahn D Vestweber 2001 The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter Nat Genet 28 69 72 10.1038/88289 11326279
52. BH Luo CV Carman TA Springer 2007 Structural basis of integrin regulation and signaling Annu Rev Immunol 25 619 647 10.1146/annurev.immunol.25.022106. 141618 1:CAS:528:DC%2BD2sXltlansrc%3D 17201681
53. YQ Ma J Qin C Wu EF Plow 2008 Kindlin-2 (Mig-2): a co-activator of beta3 integrins J Cell Biol 181 439 446 10.1083/jcb.200710196 1:CAS:528: DC%2BD1cXlsl2nu7Y%3D 18458155
54. E Manevich-Mendelson SW Feigelson R Pasvolsky M Aker V Grabovsky Z Shulman SS Kilic MA Rosenthal-Allieri S Ben-Dor A Mory A Bernard M Moser A Etzioni R Alon 2009 Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions Blood 114 2344 2353 10.1182/blood-2009-04-218636 1:CAS:528:DC%2BD1MXhtFOgt77P 19617577
55. A Marie-Cardine LR Hendricks-Taylor NJ Boerth H Zhao B Schraven GA Koretzky 1998 Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 J Biol Chem 273 25789 25795 10.1074/jbc.273.40.25789 1:CAS:528:DyaK1cXms1egtrw%3D 9748251
56. A Marie-Cardine AM Verhagen C Eckerskorn B Schraven 1998 SKAPHOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55 FEBS Lett 435 55 60 10.1016/S0014-5793(98)01040-0 1:CAS:528:DyaK1cXmtlSnur4%3D 9755858
57. G Menasche S Kliche EJ Chen TE Stradal B Schraven G Koretzky 2007 RIAM links the ADAP/SKAP-55 signaling module to Rap1 facilitating TCR-mediated integrin activation Mol Cell Biol 27 4070 4081 10.1128/MCB.02011-06 1:CAS:528:DC%2BD2sXlvVGksbw%3D 17403904
58. A Mócsai M Zhou F Meng VL Tybulewicz CA Lowell 2002 Syk is required for integrin signaling in neutrophils Immunity 16 547 558 10.1016/S1074-7613(02)00303-5 11970878
59. A Mócsai CL Abram Z Jakus Y Hu LL Lanier CA Lowell 2006 Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs Nat Immunol 7 1326 1333 10.1038/ni1407 17086186
60. E Montanez S Ussar M Schifferer M Bösl R Zent M Moser R Fässler 2008 Kindlin-2 controls bidirectional signaling of integrins Genes Dev 22 1325 1330 10.1101/gad.469408 1:CAS:528:DC%2BD1cXmsVWmsbY%3D 18483218
61. M Moser B Nieswandt S Ussar M Pozgajova R Fässler 2008 Kindlin-3 is essential for integrin activation and platelet aggregation Nat Med 14 325 330 10.1038/nm1722 1:CAS:528:DC%2BD1cXivFOrtL4%3D 18278053
62. Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV, Sperandio M, Fässler R (2009) Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med 15
63. M Moser KR Legate R Zent R Fässler 2009 The tail of integrins, talin, and kindlins Science 324 895 899 10.1126/science.1163865 1:CAS:528:DC%2BD1MXlslWnu7k%3D 19443776
64. MA Musci LR Hendricks-Taylor DG Motto M Paskind J Kamens CW Turck GA Koretzky 1997 Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases J Biol Chem 272 11674 11677 10.1074/jbc.272.18.11674 1:CAS:528:DyaK2sXivF2ksLo%3D 9115214
65. SA Newbrough A Mocsai RA Clemens JN Wu MA Silverman AL Singer CA Lowell GA Koretzky 2003 SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils Immunity 19 761 769 10.1016/S1074-7613(03)00305-4 14614862
66. A Obergfell BA Judd MA del Pozo MA Schwartz GA Koretzky SJ Shattil 2001 The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton J Biol Chem 276 5916 5923 10.1074/jbc.M010639200 1:CAS:528:DC%2BD3MXhs1Kmtb0%3D 11113155
67. CL Oxley NJ Anthis ED Lowe I Vakonakis ID Campbell KL Wegener 2008 An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding J Biol Chem 283 5420 5426 10.1074/jbc.M709435200 1:CAS:528:DC%2BD1cXit1Omsbc%3D 18156175
68. AC Pearce OJ McCarty SD Calaminus E Vigorito M Turner SP Watson 2007 Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3 Biochem J 401 753 761 10.1042/BJ20061508 1:CAS:528: DC%2BD2sXhsFGlt7k%3D 17054426
69. EJ Peterson ML Woods SA Dmowski G Derimanov MS Jordan JN Wu PS Myung QH Liu JT Pribila BD Freedman Y Shimizu GA Koretzky 2001 Coupling of the TCR to integrin activation by Slap-130/Fyb Science 293 2263 2265 10.1126/science. 1063486 1:CAS:528:DC%2BD3MXntFCqsro%3D 11567141
70. M Raab AJ da Silva PR Findell CE Rudd 1997 Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2 Immunity 6 155 164 10.1016/S1074-7613(00)80422-7 1:CAS:528:DyaK2sXhsFaisrw%3D 9047237
71. M Raab H Kang A da Silva X Zhu CE Rudd 1999 FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells J Biol Chem 274 21170 21179 10.1074/jbc.274.30.21170 1:CAS:528:DyaK1MXkvVKrsb8%3D 10409671
72. CE Rudd JM Trevillyan JD Dasgupta LL Wong SF Schlossman 1988 The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp 58) from human T lymphocytes Proc Natl Acad Sci U S A 85 5190 5194 10.1073/pnas.85.14.5190 1:CAS:528:DyaL1cXkvFSrtLk%3D 2455897
73. CE Rudd 1999 Adaptors and molecular scaffolds in immune cell signaling Cell 96 5 8 10.1016/S0092-8674(00)80953-8 1:CAS:528:DyaK1MXmslahug%3D%3D 9989491
74. K Scharffetter-Kochanek H Lu K Norman N van Nood F Munoz S Grabbe M McArthur I Lorenzo S Kaplan K Ley CW Smith CA Montgomery S Rich AL Beaudet 1998 Spontaneous skin ulceration and defective T cell function in CD18 null mice J Exp Med 188 119 131 10.1084/jem.188.1.119 1:CAS:528:DyaK1cXksFOhu74%3D 9653089
75. R Schmits TM Kundig DM Baker G Shumaker JJ Simard G Duncan A Wakeham A Shahinian A van der Heiden MF Bachmann PS Ohashi TW Mak DD Hickstein 1996 LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor J Exp Med 183 1415 1426 10.1084/jem.183.4.1415 1:CAS:528:DyaK28XisFenurg%3D 8666900
76. H Schneider B Guerette C Guntermann CE Rudd 2000 Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells J Biol Chem 275 3835 3840 10.1074/jbc.275.6.3835 1:CAS:528:DC%2BD3cXht12gsr0%3D 10660534
77. PL Schwartzberg LD Finkelstein JA Readinger 2005 TEC-family kinases: regulators of T-helper-cell differentiation Nat Rev Immunol 5 284 295 10.1038/nri1591 1:CAS:528:DC%2BD2MXivVaku7Y%3D 15803148
78. E Sebzda M Bracke T Tugal N Hogg DA Cantrell 2002 Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling Nat Immunol 3 251 258 10.1038/ni765 1:CAS:528:DC%2BD38XitVWltL4%3D 11836528
79. AS Sechi J Wehland 2004 Interplay between TCR signalling and actin cytoskeleton dynamics Trends Immunol 25 257 265 10.1016/j.it.2004.03.003 1:CAS:528:DC%2BD2cXjtFOitLY%3D 15099566
80. D Sheppard 2000 In vivo functions of integrins: lessons from null mutations in mice Matrix Biology 19 203 209 10.1016/S0945-053X(00)00065-2 1:CAS:528:DC%2BD3cXmtFyhurk%3D 10936445
81. X Shi YQ Ma Y Tu K Chen S Wu K Fukuda J Qin EF Plow C Wu 2007 The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility J Biol Chem 282 20455 20466 10.1074/jbc.M611680200 1:CAS:528: DC%2BD2sXnsFWnuro%3D 17513299
82. M Shimonaka K Katagiri T Nakayama N Fujita T Tsuruo O Yoshie T Kinashi 2003 Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow J Cell Biol 161 417 427 10.1083/jcb.200301133 1:CAS:528:DC%2BD3sXjtl2itrw%3D 12707305
83. L Steinman 2005 Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab Nat Rev Drug Discov 4 510 518 10.1038/nrd1752 1:CAS:528:DC%2BD2MXks12ktrg%3D 15931259
84. LE Stephens AE Sutherland IV Klimanskaya A Andrieux J Meneses RA Pedersen CH Damsky 1995 Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality Genes Dev 9 1883 1885 10.1101/gad.9.15.1883 1:CAS:528:DyaK2MXns1aqtbw%3D 7544312
85. L Svensson K Howarth A McDowall I Patzak R Evans S Ussar M Moser A Metin M Fried I Tomlinson N Hogg 2009 Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation Nat Med 15 306 312 10.1038/nm.1931 1:CAS:528:DC%2BD1MXitFKmtbw%3D 19234463
86. J Takagi BM Petre T Walz TA Springer 2002 Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling Cell 110 599 511 10.1016/S0092-8674(02)00935-2 1:CAS:528: DC%2BD38XntlOhsbs%3D 12230977
87. J Takagi TA Springer 2002 Integrin activation and structural rearrangement Immunol Rev 186 141 163 10.1034/j.1600-065X.2002.18613.x 1:CAS:528:DC%2BD38XotFeht7Y%3D 12234369
88. Y Tu S Wu X Shi K Chen C Wu 2003 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation Cell 113 37 47 10.1016/S0092-8674(03)00163-6 1:CAS:528:DC%2BD3sXjtVWqsLo%3D 12679033
89. S Ussar HV Wang S Linder R Fässler M Moser 2006 The Kindlins: subcellular localization and expression during murine development Exp Cell Res 312 3142 3151 10.1016/j.yexcr.2006.06.030 1:CAS:528:DC%2BD28XptFSqurs%3D 16876785
90. S Ussar M Moser M Widmaier E Rognoni C Harrer O Genzel-Boroviczeny R Fässler 2008 Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction PLoS Genet 4 e1000289 10.1371/journal.pgen. 1000289 19057668
91. Y van Kooyk P Weder K Heije CG Figdor 1994 Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion J Cell Biol 124 1061 1070 10.1083/jcb.124.6.1061 7510713
92. M Veale M Raab Z Li AJ da Silva SK Kraeft S Weremowicz CC Morton R CE 1999 Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production J Biol Chem 274 28427 28435 10.1074/jbc.274.40.28427 1:CAS:528:DyaK1MXmsFWgtbY%3D 10497204
93. H Wang EY Moon A Azouz X Wu A Smith H Schneider N Hogg CE Rudd 2003 SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates Nat Immunol 4 366 374 10.1038/ni913 1:CAS:528:DC%2BD3sXitlyqs7Y%3D 12652296
94. H Wang H Liu Y Lu M Lovatt B Wei CE Rudd 2007 Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion Mol Cell Biol 27 6863 6875 10.1128/MCB.00556-07 1:CAS:528: DC%2BD2sXhtFSktLzK 17646386
95. Wang H, Lu Y, Rudd CE (2009) SKAP1 is dispensable for chemokine-induced migration of primary T-cells. Immunol Lett Oct 31.
96. H Wang B Wei G Bismuth CE Rudd 2009 SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility Proc Natl Acad Sci U S A 106 12436 12441 10.1073/pnas.0900510106 1:CAS:528:DC%2BD1MXpslGjtr0%3D 19617540
97. KL Wegener AW Partridge J Han AR Pickford RC Liddington G MH ID Campbell 2007 Structural basis of integrin activation by talin Cell 128 171 182 10.1016/j.cell.2006.10.048 1:CAS:528:DC%2BD2sXptl2gsg%3D%3D 17218263
98. JT Yang H Rayburn RO Hynes 1993 Embryonic mesodermal defects in alpha 5 integrin-deficient mice Development 119 1093 1105 1:CAS:528:DyaK2cXivFCrtbY%3D 7508365
99. JT Yang H Rayburn RO Hynes 1995 Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development Development 121 549 560 1:CAS:528:DyaK2MXjsl2ntLo%3D 7539359