Syk is required for integrin signaling in neutrophils

Immunity

Volumn 16, Issue 4, 2002, Pages 547-558

  Mócsai, Attila ^a   Zhou, Meijuan ^a   Meng, Fanying ^a   Tybulewicz, Victor L ^b   Lowell, Clifford A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; PROTEIN KINASE SYK; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; CROSS LINKING; DEGRANULATION; EMBRYO; GENE DELETION; INFLAMMATION; LEUKOCYTE ACTIVATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; PROTEIN LOCALIZATION; PROTEIN POLYMERIZATION; RESPIRATORY BURST; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

EID: 0036231179     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00303-5     Document Type: Article

References (42)

1. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
2. Syk tyrosine kinase required for mouse viability and B-cell development
3. The Syk family of protein tyrosine kinases in T-cell activation and development
4. 3
5. A new look at Syk in αβ and γδ T cell development using chimeric mice with a low competitive hematopoietic environment
6. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
7. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells
8. Cγ receptors on macrophages
9. 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst
10. Integrin-mediated muscle cell spreading. The role of protein kinase C in outside-in and inside-out signaling and evidence of integrin cross- talk
11. 2 release in adherent human neutrophils
12. 3
13. Cγ receptor signaling in macrophages and neutrophils
14. 3 to lamellipodia in endothelial cell migration
15. 3 signaling in platelets
16. Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase
17. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr
18. Integrin signal transduction in myeloid leukocytes
19. Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity
20. c-fgr results in defective adhesion-dependent neutrophil functions
21. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
22. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
23. 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
24. Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs
25. Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD18-deficient mice
26. Differential effects of tyrosine kinase inhibitors and an inhibitor of the mitogen-activated protein kinase cascade on degranulation and superoxide production of human neutrophil granulocytes
27. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck
28. Kinase pathways in chemoattractant-induced degranulation of neutrophils: The role of p38 mitogen-activated protein kinase activated by Src family kinases
29. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes
30. Cytokine-induced respiratory burst of human neutrophils: Dependence on extracellular matrix proteins and CD11/CD18 integrins
31. 3 initiate integrin signaling to the cytoskeleton
32. 4 integrins that signal through Src family kinases
33. Cell surface distribution of high-avidity LFA-1 detected by soluble ICAM-1-coated microspheres
34. 2+
35. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
36. Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells
37. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
38. Tyrosine kinase SYK: Essential functions for immunoreceptor signalling
39. 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr
40. Impairment of neutrophil emigration in CD18-null mice
41. Gene targeting yields a CD18-mutant mouse for study of inflammation
42. syk and Src family kinases in neutrophils spreading over fibrinogen