A phosphoinositide 3-kinase-γ inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats

Biochemical and Biophysical Research Communications

Volumn 397, Issue 2, 2010, Pages 311-317

  Wei, Xin ^a   Han, Jing ^a   Chen, Zhi Zhi ^a   Qi, Bao Wen ^a   Wang, Guang Cheng ^a   Ma, Ying Hua ^a   Zheng, Hao ^a   Luo, You Fu ^a   Wei, Yu Quan ^a   Chen, Li Juan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

AS605240; Bleomycin; Inflammation; Phosphoinositide 3 kinase ; Pulmonary fibrosis

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; BLEOMYCIN; COLLAGEN; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 QUINOXALIN 6 YLMETHYLENETHIAZOLIDINE 2,4 DIONE; 5-QUINOXALIN-6-YLMETHYLENETHIAZOLIDINE-2,4-DIONE; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; QUINOXALINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; INFLAMMATORY CELL; LUNG FIBROSIS; LYMPHOCYTIC INFILTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLEOMYCIN; ENZYME INHIBITORS; FEMALE; PULMONARY FIBROSIS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLIDINEDIONES;

EID: 77955480020     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.109     Document Type: Article

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