A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines

Tetrahedron Letters

Volumn 51, Issue 36, 2010, Pages 4755-4758

  Ducray, Richard ^a   Boutron, Pascal ^a   Didelot, Myriam ^a   Germain, Hervé ^a   Lach, Franck ^a   Lamorlette, Maryannick ^a   Legriffon, Antoine ^a   Maudet, Mickael ^a   Ménard, Morgan ^a   Pasquet, Georges ^a   Renaud, Fabrice ^a   Simpson, Iain ^a   Young, Gail L ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (PYRIMIDIN 4 YL) IMIDAZO[1,2 ALPHA]PYRIDINE DERIVATIVE; 3 (PYRIMIDIN 4 YL) PYRAZOLO[1,5 ALPHA]PYRIDINE DERIVATIVE; ETHER DERIVATIVE; IMIDAZOPYRIDINE DERIVATIVE; LIGAND; PYRIDINE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CYCLOADDITION; HECK REACTION; METHODOLOGY; SUZUKI REACTION; SYNTHESIS;

EID: 77955470753     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.07.024     Document Type: Article

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23. +).
24. When performed on a large scale, we were able to reduce the amount of 1-(vinyloxy)butane down to 1.2 equiv.
25. When performed on such a scale, an exothermic reaction was observed with an onset temperature of about 70 °C, leading to an internal temperature of up to 120 °C. It is therefore recommended to perform this reaction on a smaller scale unless appropriate control measures are in place.