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Volumn 5, Issue 8, 2003, Pages 1369-1372

Synthesis of novel imidazo[1,2-a]pyridines with potent activity against herpesviruses

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; IMIDAZOPYRIDINE DERIVATIVE; AMINE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE; PYRIMIDINE DERIVATIVE;

EID: 0038601656     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0343616     Document Type: Article
Times cited : (97)

References (30)
  • 1
    • 0001142642 scopus 로고    scopus 로고
    • Knipe, D. M., Howley, P. M., Eds.; Lippincott Williams and Wilkins: Philadelphia, PA
    • Roizman, B.; Pellett, P. E. In Fields Virology; Knipe, D. M., Howley, P. M., Eds.; Lippincott Williams and Wilkins: Philadelphia, PA, 2001; Vol. 2, p 2381.
    • (2001) Fields Virology , vol.2 , pp. 2381
    • Roizman, B.1    Pellett, P.E.2
  • 11
    • 0035205335 scopus 로고    scopus 로고
    • For publications describing different imidazopyridines with antiherpetic activity, see: (a) Chaouni-Bendallah, A.; Galtier, C.; Allouchi, H.; Kherbeche, A.; Chavignon, O.; Teulade, J.-C. et al. Chem. Pharm. Bull. 2001, 49, 1631. (b) Mavel, S.; Renou, J. L.; Galtier, C.; Snoeck, R.; Andrei, G.; Balzarini, J.; De Clercq, E.; Gueiffier, A. Arzneimittel-Forschung 2001, 51, 304. (c) Lhassani, M.; Chavignon, O.; Chezal, J.-M.; Teulade, J.-C.; Chapat, J.-P.; Snoeck, R.; Andrei, G.; Balazarini, J.; De Clercq, E.; Gueiffier, A. Eur. J. Med. Chem. 1999, 34, 271.
    • (2001) Chem. Pharm. Bull. , vol.49 , pp. 1631
    • Chaouni-Bendallah, A.1    Galtier, C.2    Allouchi, H.3    Kherbeche, A.4    Chavignon, O.5    Teulade, J.-C.6
  • 12
    • 0035029042 scopus 로고    scopus 로고
    • For publications describing different imidazopyridines with antiherpetic activity, see: (a) Chaouni-Bendallah, A.; Galtier, C.; Allouchi, H.; Kherbeche, A.; Chavignon, O.; Teulade, J.-C. et al. Chem. Pharm. Bull. 2001, 49, 1631. (b) Mavel, S.; Renou, J. L.; Galtier, C.; Snoeck, R.; Andrei, G.; Balzarini, J.; De Clercq, E.; Gueiffier, A. Arzneimittel-Forschung 2001, 51, 304. (c) Lhassani, M.; Chavignon, O.; Chezal, J.-M.; Teulade, J.-C.; Chapat, J.-P.; Snoeck, R.; Andrei, G.; Balazarini, J.; De Clercq, E.; Gueiffier, A. Eur. J. Med. Chem. 1999, 34, 271.
    • (2001) Arzneimittel-Forschung , vol.51 , pp. 304
    • Mavel, S.1    Renou, J.L.2    Galtier, C.3    Snoeck, R.4    Andrei, G.5    Balzarini, J.6    De Clercq, E.7    Gueiffier, A.8
  • 13
    • 0032708901 scopus 로고    scopus 로고
    • For publications describing different imidazopyridines with antiherpetic activity, see: (a) Chaouni-Bendallah, A.; Galtier, C.; Allouchi, H.; Kherbeche, A.; Chavignon, O.; Teulade, J.-C. et al. Chem. Pharm. Bull. 2001, 49, 1631. (b) Mavel, S.; Renou, J. L.; Galtier, C.; Snoeck, R.; Andrei, G.; Balzarini, J.; De Clercq, E.; Gueiffier, A. Arzneimittel-Forschung 2001, 51, 304. (c) Lhassani, M.; Chavignon, O.; Chezal, J.-M.; Teulade, J.-C.; Chapat, J.-P.; Snoeck, R.; Andrei, G.; Balazarini, J.; De Clercq, E.; Gueiffier, A. Eur. J. Med. Chem. 1999, 34, 271.
    • (1999) Eur. J. Med. Chem. , vol.34 , pp. 271
    • Lhassani, M.1    Chavignon, O.2    Chezal, J.-M.3    Teulade, J.-C.4    Chapat, J.-P.5    Snoeck, R.6    Andrei, G.7    Balazarini, J.8    De Clercq, E.9    Gueiffier, A.10
  • 17
    • 0141659601 scopus 로고    scopus 로고
    • note
    • Use of the more reactive dimethylformamide-di-tert-butylacetal in DMF shortened the reaction time to 36 h but gave a similar yield of the desired product (56%).
  • 28
    • 0141659600 scopus 로고    scopus 로고
    • note
    • Suzuki couplings of 17 with pyridylboronic acids gave 50-60% yield of the desired coupled product.
  • 30
    • 0003013170 scopus 로고    scopus 로고
    • A similar cyclization protocol appeared in the literature during the course of our work: (a) Adlington, R. M.; Baldwin, J. E.; Catterick, D.; Pritchard, G. J. J. Chem. Soc., Perkin Trans. 1 1999, 855. (b) Adlington, R. M. ; Baldwin, J. E.; Catterick, D.; Pritchard, G. J. Chem. Commun. 1997, 1757.
    • (1997) J. Chem. Commun. , pp. 1757
    • Adlington, R.M.1    Baldwin, J.E.2    Catterick, D.3    Pritchard, G.4


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