Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II

European Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2008, Pages 1123-1151

  Scribner, Andrew ^a   Dennis, Richard ^a   Lee, Shuliang ^a   Ouvry, Gilles ^a   Perrey, David ^a   Fisher, Michael ^b   Wyvratt, Matthew ^b   Leavitt, Penny ^b   Liberator, Paul ^b   Gurnett, Anne ^b   Brown, Chris ^b   Mathew, John ^b   Thompson, Donald ^b   Schmatz, Dennis ^b   Biftu, Tesfaye ^b  

^a SCYNEXIS Inc   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antiparasitic; Antiprotozoal; Coccidiosis; Imidazopyridine; Kinase

Indexed keywords

2 [4 [3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 7 YL]PIPERIDIN 1 YL]ETHANOL; 2 [4 [3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 7 YL]PIPERIDIN 1 YL]PROPAN 1 OL; 2 [[3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 7 YLMETHYL]METHYLAMINO]ETHANOL; 3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL) N,N DIMETHYLIMIDAZO[1,2 A]PYRIDINE 7 CARBOXAMIDINE; 3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDINE 7 CARBOXYLIC ACID AMIDE; 3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDINE 7 CARBOXYLIC ACID METHYL AMIDE; 4 [2 (4 FLUOROPHENYL) 7 (1 ISOBUTYLPIPERIDIN 4 YL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [2 (4 FLUOROPHENYL) 7 (4 METHYLPIPERAZIN 1 YLMETHYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [2 (4 FLUOROPHENYL) 7 [(METHYLPROP 2 YNYLAMINO) METHYL]IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [2 (4 FLUOROPHENYL) 7 [1 (2 METHYLBUTYL)PIPERIDIN 4 YL]IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [2 (4 FLUOROPHENYL) 7 [[(2 METHOXYETHYL)METHYLAMINO]METHYL]IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [2 (4 FLUOROPHENYL) 7 PIPERIDIN 4 YLIMIDAZO[1,2-A]PYRIDIN 3 YL]PIPERIDIN 2 YLAMINE; 4 [7 (1 AMINO 1 METHYLETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 CYCLOPROPYLMETHYLPIPERIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 DIMETHYLAMINO 1 METHYLETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 DIMETHYLAMINOBUTYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 DIMETHYLAMINOETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 DIMETHYLAMINOMETHYLPROPYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 DIMETHYLAMINOPROPYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (1 ETHYLPIPERIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (2 AMINO 1,1 DIMETHYLETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (2 DIMETHYLAMINO 1 FLUOROETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (2 DIMETHYLAMINO 1,1 DIMETHYLETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (2 DIMETHYLAMINOETHYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 (3 DIMETHYLAMINOPROPYL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; 4 [7 DIETHYLAMINOMETHYL 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]PYRIMIDIN 2 YLAMINE; [[3 (2 AMINOPYRIMIDIN 4 YL) 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 7 YLMETHYL]METHYLAMINO]ACETONITRILE; COCCIDIOSTATIC AGENT; IMIDAZOPYRIDINE DERIVATIVE; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHICKEN; COCCIDIOSIS; CONTROLLED STUDY; DERIVATIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EIMERIA; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; COCCIDIOSTATS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EIMERIA; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN KINASE INHIBITORS; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 44349105853     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.09.013     Document Type: Article

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