Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2479-2483

  Biftu, Tesfaye ^a   Feng, Dennis ^a   Fisher, Michael ^a   Liang, Gui Bai ^a   Qian, Xiaoxia ^a   Scribner, Andrew ^b   Dennis, Richard ^b   Lee, Shuliang ^b   Liberator, Paul A ^a   Brown, Chris ^a   Gurnett, Anne ^a   Leavitt, Penny S ^a   Thompson, Donald ^a   Mathew, John ^a   Misura, Andrew ^a   Samaras, Samantha ^a   Tamas, Tamas ^a   Sina, Joseph F ^a   McNulty, Kathleen A ^a   McKnight, Crystal G ^a   Schmatz, Dennis M ^a   Wyvratt, Matthew ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b SCYNEXIS Inc   (United States)

Author keywords

Anticoccidial; Antiprotozoan; Imidazopyridine; Protein kinase G

Indexed keywords

ANTIPROTOZOAL AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; IMIDAZOPYRIDINE DERIVATIVE;

AMES TEST; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CHICKEN; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EIMERIA TENELLA; ENZYME INHIBITION; GENOTOXICITY; IC 50; IN VIVO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMAL FEED; ANIMALS; ANTIPROTOZOAL AGENTS; CHICKENS; COCCIDIOSIS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EIMERIA TENELLA; ENZYME INHIBITORS; IMIDAZOLES; MALE; MOLECULAR STRUCTURE; MUTAGENICITY TESTS; OOCYSTS; PARASITIC SENSITIVITY TESTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; EIMERIA TENELLA; GALLUS GALLUS; RODENTIA;

EID: 33644986999     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.092     Document Type: Article

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